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Identification of an Efflux Pump Gene, pmrA , Associated with Fluoroquinolone Resistance in Streptococcus pneumoniae
Open accessAbstract
An open reading frame (ORF) homologous to norA was insertionally inactivated with cat in a fluoroquinolone-resistant pneumococcus with an efflux phenotype; this inactivation caused reversion to drug sensitivity. The ORF product has 24% amino acid sequence identity each to NorA and Bmr, which suggests that it is a major facilitator system pump of the 12-transmembrane-segment class.
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Citations
Cited by
Clinically Relevant Chromosomally Encoded Multidrug Resistance Efflux Pumps in Bacteria
Piddock, L. J. V. (2006) · Clinical Microbiology Reviews · doi:10.1128/cmr.19.2.382-402.2006 · Cited by 1,231
Efflux-mediated antimicrobial resistance
Poole, K. (2005) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dki171 · Cited by 1,082
Mechanisms of Action and Resistance of Older and Newer Fluoroquinolones
Hooper, D. C. (2000) · Clinical Infectious Diseases · doi:10.1086/314056 · Cited by 409
Fluoroquinolone resistance among Gram-positive cocci
Hooper, D. C. (2002) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(02)00369-9 · Cited by 320
Metadata
- Authors
- Gill, M. J., Brenwald, N. P., & Wise, R.
- Venue
- Antimicrobial Agents and Chemotherapy
- Publisher
- American Society for Microbiology
- Published
- 1999-01
- Volume
- 43
- Issue
- 1
- Pages
- 187-189
- ISSN
- 0066-4804 (ISSN-L)
- 1098-6596
- OpenAlex
- W2160852967
- Cited by
- 259
- References
- 0
- FWCI
- 13.03
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Identification of an Efflux Pump Gene, pmrA , Associated with Fluoroquinolone Resistance in Streptococcus pneumoniae. https://app.cochat.ai/papers/10.1128/aac.43.1.187
- The paper
- Gill, M. J., Brenwald, N. P., & Wise, R. (1999). Identification of an Efflux Pump Gene, pmrA , Associated with Fluoroquinolone Resistance in Streptococcus pneumoniae. Antimicrobial Agents and Chemotherapy. https://doi.org/10.1128/aac.43.1.187
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
