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Distribution and Content of Class 1 Integrons in Different Vibrio cholerae O-Serotype Strains Isolated in Thailand
Open accessAbstract
In this study, 176 clinical and environmental Vibrio cholerae strains of different O serotypes isolated in Thailand from 1982 to 1995 were selected and studied for the presence of class 1 integrons, a new group of genetic elements which carry antibiotic resistance genes. Using PCR and DNA sequencing, we found that 44 isolates contained class 1 integrons harboring the aadB , aadA2 , blaP1 , dfrA1 , and dfrA15 gene cassettes, which encode resistance to gentamicin, kanamycin, and tobramycin; streptomycin and spectinomycin; β-lactams; and trimethoprim, respectively. Each cassette array contained only a single antibiotic resistance gene. Although resistance genes in class 1 integrons were found in strains from the same epidemic, as well as in unrelated non-O1, non-O139 strains isolated from children with diarrhea, they were found to encode only some of the antibiotic resistance expressed by the strains. Serotype O139 strains did not contain class 1 integrons. However, the appearance and disappearance of the O139 serotype in the coastal city Samutsakorn in 1992 and 1993 were associated with the emergence of a distinct V. cholerae O1 strain which contained the aadA2 resistance gene cassette. A 150-kb self-transmissible plasmid found in three O1 strains isolated in 1982 contained the aadB gene cassette. Surprisingly, several strains harbored two integrons containing different cassettes. Thus, class 1 integrons containing various resistance gene cassettes are distributed among different V. cholerae O serotypes of mainly clinical origin in Thailand.
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In the citing paper
“the aadA1 gene that confers resistance against aminoglycosides, streptomycin, and spectinomycin (4,5).”
From Class I Integrons and SXT Elements in El Tor Strains Isolated before and after 1992 Vibrio cholerae O139 Outbreak, Calcutta, India (2003) · cites this paper as [5]
In the citing paper
“The ribotype of the pre-O139, O1 Calcutta strains examined in this study was identical to that of the Samutsakorn strains (4,5,8).”
From Class I Integrons and SXT Elements in El Tor Strains Isolated before and after 1992 Vibrio cholerae O139 Outbreak, Calcutta, India (2003) · cites this paper as [5]
In the citing paper
“Both pre- and post-O139 isolates carried class I integrons with the aadA2 gene cassette.”
From Class I Integrons and SXT Elements in El Tor Strains Isolated before and after 1992 Vibrio cholerae O139 Outbreak, Calcutta, India (2003) · cites this paper as [5]
In the citing paper
“Class I integrons have been detected in V. cholerae O1 strains isolated in Vietnam, Thailand, and Italy (4–6).”
From Class I Integrons and SXT Elements in El Tor Strains Isolated before and after 1992 Vibrio cholerae O139 Outbreak, Calcutta, India (2003) · cites this paper as [5]
In the citing paper
“When the data presented in this paper are considered together with the information presented by others (4,5,8,10), it appears that both pre- and post-O139, O1 strains, isolated in Calcutta, probably could have moved to other countries and became established there.”
From Class I Integrons and SXT Elements in El Tor Strains Isolated before and after 1992 Vibrio cholerae O139 Outbreak, Calcutta, India (2003) · cites this paper as [5]
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Metadata
- Authors
- Dalsgaard, A., Forslund, A., Serichantalergs, O., & Sandvang, D.
- Affiliations
- <!--label omitted: 1-->Department of Veterinary Microbiology, Royal Veterinary and Agricultural University, Frederiksberg, DK-1870 Frederiksberg C,1 and
- Armed Forces Research Institute of Medical Science (TH)
- ORCID
- Dalsgaard, Anders
- Venue
- Antimicrobial Agents and Chemotherapy
- Publisher
- American Society for Microbiology
- Published
- 2000-05
- Volume
- 44
- Issue
- 5
- Pages
- 1315-1321
- ISSN
- 0066-4804 (ISSN-L)
- 1098-6596
- PMC
- PMC89861
- OpenAlex
- W2141939691
- Cited by
- 118
- References
- 60
- Citations by year
- 2026: 2 · 2024: 3 · 2023: 2 · 2022: 3 · 2021: 1 · 2020: 7 · 2019: 4 · 2018: 3 · 2017: 1 · 2016: 3 · 2015: 6 · 2014: 7 · 2013: 3 · 2012: 3
- FWCI
- 3.76
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Antimicrobial Agents and Chemotherapy (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
- Technical University of Denmark, DTU Orbit (Technical University of Denmark, DTU) (submittedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Microbiology › Vibrio bacteria research studies
- Health Sciences › Medicine › Microbiology (medical) › Antibiotic Resistance in Bacteria
- Life Sciences › Agricultural and Biological Sciences › Food Science › Salmonella and Campylobacter epidemiology
- Keywords
- class 1 integron, Vibrio cholerae, O serotypes, antibiotic resistance genes, aadB, aadA2, dfrA1, serotype O1, self-transmissible plasmids, gene cassettes, clinical and environmental isolates, Thailand
- MeSH terms
- Animals, Anti-Bacterial Agents, Drug Resistance, Microbial, Environmental Microbiology, Food Contamination, Food Microbiology, Genes, Bacterial, Humans, Microbial Sensitivity Tests, Thailand, Vibrio cholerae, Seafood, Decapoda
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