In vivo antimalarial activity of the beta-carboline alkaloid manzamine A
Open accessAbstract
Manzamine A, a β-carboline alkaloid present in several marine sponge species, inhibits the growth of the rodent malaria parasite Plasmodium berghei in vivo. More than 90% of the asexual erythrocytic stages of P. berghei were inhibited after a single intraperitoneal injection of manzamine A into infected mice. A remarkable aspect of manzamine A treatment is its ability to prolong the survival of highly parasitemic mice, with 40% recovery 60 days after a single injection. Oral administration of an oil suspension of manzamine A also produced significant reductions in parasitemia. The plasma manzamine A concentration peaked 4 h after injection and remained high even at 48 h. Morphological changes of P. berghei were observed 1 h after treatment of infected mice. (−)-8-Hydroxymanzamine A also displayed antimalarial activity, whereas manzamine F, a ketone analog of manzamine A, did not. Our results suggest that manzamine A and (−)-8-hydroxymanzamine A are promising new antimalarial agents.
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Advanced technology and extensive research on marine natural products have led to the discovery of a new generation of anticancer drugs currently used in clinical trials.
“Advanced technology and extensive research on marine natural products have led to the discovery of a new generation of anticancer drugs currently used in clinical trials [6].”
From Marine Natural Products: A Source of Novel Anticancer Drugs (2019) · cites this paper as [6]
The Abstract (page not specified) says marine-sponge manzamines had attracted interest as potential anticancer agents and inhibited cancer-cell growth. It does not say that advanced technology produced a new generation of anticancer drugs or that any were in clinical trials; this paper reports antimalarial testing in mice. (LLM, conf=0.87)
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Marine Natural Products: A Source of Novel Anticancer Drugs
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Self-citation
- Authors
- Ang, K. K. H., Holmes, M. J., Higa, T., Hamann, M. T., & Kara, U. A. K.
- Affiliations
- National University of Singapore (SG)
- University of the Ryukyus (JP)
- University of Mississippi (US)
- Venue
- Antimicrobial Agents and Chemotherapy
- Publisher
- American Society for Microbiology
- Published
- 2000-06
- Volume
- 44
- Issue
- 6
- Pages
- 1645-1649
- ISSN
- 0066-4804 (ISSN-L)
- 1098-6596
- PMC
- PMC89926
- OpenAlex
- W2159998023
- Cited by
- 218
- References
- 21
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 3 · 2023: 8 · 2022: 9 · 2021: 12 · 2020: 16 · 2019: 10 · 2018: 6 · 2017: 9 · 2016: 5 · 2015: 8 · 2014: 18 · 2013: 8 · 2012: 11
- FWCI
- 1.93
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Antimicrobial Agents and Chemotherapy (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- National University of Singapore (submittedVersion)
- Funders
- National University of Singapore
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Synthesis and bioactivity of alkaloids
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Malaria Research and Control
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Marine Sponges and Natural Products
- Keywords
- manzamine A, β-carbolines, antimalarial activity, Plasmodium berghei, marine sponges, oral bioavailability, parasitemia reduction, single-dose therapy
- MeSH terms
- Animals, Antimalarials, Carbazoles, Indoles, Malaria, Male, Microscopy, Electron, Plasmodium berghei, Pyrroles, Mice
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