Marine natural products and their potential applications as anti-infective agents
Open accessAbstract
The oceans are a unique resource that provide a diverse array of natural products, primarily from invertebrates such as sponges, tunicates, bryozoans, and molluscs, and from marine bacteria and cyanobacteria. As infectious diseases evolve and develop resistance to existing pharmaceuticals, the marine environment provides novel leads against fungal, parasitic, bacterial, and viral diseases. Many marine natural products have successfully advanced to the late stages of clinical trials, including dolastatin 10, ecteinascidin-743, kahalalide F, and aplidine, and a growing number of candidates have been selected as promising leads for extended preclinical assessment. Although many marine-product clinical trials are for cancer chemotherapy, drug resistance, emerging infectious diseases, and the threat of bioterrorism have all contributed to the interest in assessing natural ocean products in the treatment of infectious organisms. In this review, we focus on the pharmacologically tested marine leads that have shown in-vivo efficacy or potent in-vitro activity against infectious and parasitic diseases.
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Gambierdiscus toxicus produces gambieric acids, which have antifungal activities.
“Gambierdiscus toxicus produces gambieric acids, which have antifungal activities [214].”
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- Authors
- Donia, M., & Hamann, M. T.
- Affiliations
- University of Mississippi (US)
- Corresponding author
- Hamann, Mark T
- ORCID
- Hamann, Mark T
- Venue
- The Lancet Infectious Diseases
- Publisher
- Elsevier BV
- Published
- 2003-06
- Volume
- 3
- Issue
- 6
- Pages
- 338-348
- ISSN
- 1473-3099 (ISSN-L)
- PMC
- PMC7106398
- OpenAlex
- W2165757703
- Cited by
- 425
- References
- 79
- Citations by year
- 2026: 7 · 2025: 13 · 2024: 25 · 2023: 21 · 2022: 19 · 2021: 20 · 2020: 24 · 2019: 14 · 2018: 20 · 2017: 17 · 2016: 22 · 2015: 26 · 2014: 22 · 2013: 24 · 2012: 32
- FWCI
- 2.04
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Lancet Infectious Diseases (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute of Allergy and Infectious Diseases (K02AI001502, R01AI036596, KO2AI01502, R01 AI 36596)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Marine Sponges and Natural Products
- Health Sciences › Medicine › Pharmacology › Microbial Natural Products and Biosynthesis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Synthesis and Biological Activity
- Keywords
- marine natural products, anti-infective agents, marine sponges, tunicates, Bryozoa, marine bacteria, marine cyanobacteria, antifungal agents, antiparasitic drugs, antibacterial agents, antiviral agents, drug resistance, emerging infectious diseases, dolastatin 10, trabectedin, kahalalide F, marine-derived drugs
- MeSH terms
- Animals, Anthelmintics, Anti-Bacterial Agents, Antifungal Agents, Antiprotozoal Agents, Antitubercular Agents, Antiviral Agents, Humans, Invertebrates, Marine Biology, Phytotherapy, Drugs, Investigational
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