In Vitro Killing of Candida albicans by Fatty Acids and Monoglycerides
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The susceptibility of Candida albicans to several fatty acids and their 1-monoglycerides was tested with a short inactivation time, and ultrathin sections were studied by transmission electron microscopy (TEM) after treatment with capric acid. The results show that capric acid, a 10-carbon saturated fatty acid, causes the fastest and most effective killing of all three strains of C. albicans tested, leaving the cytoplasm disorganized and shrunken because of a disrupted or disintegrated plasma membrane. Lauric acid, a 12-carbon saturated fatty acid, was the most active at lower concentrations and after a longer incubation time.
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Medium-chain fatty acids and their monoglycerides have broad-spectrum microbicidal activity against a wide range of pathogens in vitro and in vivo, including multidrug-resistant bacteria, enveloped viruses, algae, fungi, and protozoa.
“Of these, medium-chain fatty acids (MCFAs) and their monoglycerides have a broad spectrum of microbicidal activity against a wide range of pathogens both in vitro and in vivo, including multidrug-resistant bacteria, enveloped viruses, algae, fungi, and protozoa (Bergsson et al., 2001; Hilmarsson et al., 2007; Yoon et al., 2018; Zhou et al., 2019; Heriyati et al., 2020; Welch et al., 2020).”
From Insect Derived Lauric Acid as Promising Alternative Strategy to Antibiotics in the Antimicrobial Resistance Scenario (2021) · cites this paper as Bergsson et al., 2001
Fatty acids may possess antibacterial and antifungal activity; the length of the fatty acid chain appears to play an important role, with lauric (C12) and capric (C10) acids showing the best antimicrobial results.
“Fatty acids may also possess antibacterial and antifungal activity. The length of the fatty acid chain appears to play an important role in antimicrobial activity, with lauric (C12) and capric (C10) acids showing the best antimicrobial results [172].”
From Lactic Acid Bacteria in Raw-Milk Cheeses: From Starter Cultures to Probiotic Functions (2022) · cites this paper as [172]
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Antifungal lactic acid bacteria as biopreservatives
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“The length of the fatty acid chain appears to play an important role in antimicrobial activity, with lauric (C12) and capric (C10) acids showing the best antimicrobial results [172].”
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- Authors
- Bergsson, G., Arnfinnsson, J., Steingrı́msson, O., & Thormar, H.
- Affiliations
- University of Iceland (IS)
- <!--label omitted: 2-->Department of Anatomy, University of Iceland Medical School,2 and
- <!--label omitted: 3-->Department of Microbiology, National University Hospital,3 Reykjavik, Iceland
- <!--label omitted: 1-->Institute of Biology, University of Iceland,1
- Venue
- Antimicrobial Agents and Chemotherapy
- Publisher
- American Society for Microbiology
- Published
- 2001-11
- Volume
- 45
- Issue
- 11
- Pages
- 3209-3212
- ISSN
- 0066-4804 (ISSN-L)
- 1098-6596
- PMC
- PMC90807
- OpenAlex
- W2121791697
- Cited by
- 289
- References
- 13
- Citations by year
- 2026: 13 · 2025: 17 · 2024: 17 · 2023: 17 · 2022: 16 · 2021: 18 · 2020: 21 · 2019: 11 · 2018: 16 · 2017: 13 · 2016: 9 · 2015: 7 · 2014: 21 · 2013: 10 · 2012: 15
- FWCI
- 2.04
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Antimicrobial Agents and Chemotherapy (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Life Sciences › Agricultural and Biological Sciences › Food Science › Essential Oils and Antimicrobial Activity
- Physical Sciences › Chemistry › Organic Chemistry › Antimicrobial agents and applications
- Keywords
- Candida albicans, fatty acids, monoglycerides, capric acid, lauric acid, antifungal activity, plasma membrane disruption, yeast morphology, saturated fatty acids
- MeSH terms
- Candida albicans, Decanoic Acids, Fatty Acids, Glycerides, Lauric Acids, Microbial Sensitivity Tests, Microscopy, Electron
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