The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
GES-2, a Class A β-Lactamase from Pseudomonas aeruginosa with Increased Hydrolysis of Imipenem
Open accessAbstract
Pseudomonas aeruginosa GW-1 was isolated in 2000 in South Africa from blood cultures of a 38-year-old female who developed nosocomial pneumonia. This isolate harbored a self-transferable ca. 100-kb plasmid that conferred an expanded-spectrum cephalosporin resistance profile associated with an intermediate susceptibility to imipenem. A β-lactamase gene, bla GES-2 , was cloned from whole-cell DNA of P. aeruginosa GW-1 and expressed in Escherichia coli . GES-2, with a pI value of 5.8, hydrolyzed expanded-spectrum cephalosporins, and its substrate profile was extended to include imipenem compared to that of GES-1, identified previously in Klebsiella pneumoniae . GES-2 activity was less inhibited by clavulanic acid, tazobactam and imipenem than GES-1. The GES-2 amino acid sequence differs from that of GES-1 by a glycine-to-asparagine substitution in position 170 located in the omega loop of Ambler class A enzymes. This amino acid change may explain the extension of the substrate profile of the plasmid-encoded β-lactamase GES-2.
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Cites
Yigit, H., Queenan, A. M., Anderson, G. J., Domenech-Sanchez, A., Biddle, J. W., Steward, C. D., Alberti, S., Bush, K., & Tenover, F. C. (2001) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.45.4.1151-1161.2001 · Cited by 1,639
Cited by
Updated Functional Classification of β-Lactamases
Bush, K., & Jacoby, G. A. (2010) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01009-09 · Cited by 2,367
Growing Group of Extended-Spectrum β-Lactamases: the CTX-M Enzymes
Bonnet, R. (2004) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.48.1.1-14.2004 · Cited by 1,494
Metallo-β-Lactamases: the Quiet before the Storm?
Walsh, T. R., Toleman, M. A., Poirel, L., & Nordmann, P. (2005) · Clinical Microbiology Reviews · doi:10.1128/cmr.18.2.306-325.2005 · Cited by 1,431
Self-citationPotron, A., Poirel, L., & Nordmann, P. (2015) · International Journal of Antimicrobial Agents · doi:10.1016/j.ijantimicag.2015.03.001 · Cited by 688
Self-citationEmerging carbapenemases in Gram-negative aerobes
Nordmann, P., & Poirel, L. (2002) · Clinical Microbiology and Infection · doi:10.1046/j.1469-0691.2002.00401.x · Cited by 684
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Metadata
- Authors
- Poirel, L., Weldhagen, G. F., Naas, T., De Champs, C., Dove, M. G., & Nordmann, P.
- Venue
- Antimicrobial Agents and Chemotherapy
- Publisher
- American Society for Microbiology
- Published
- 2001-09
- Volume
- 45
- Issue
- 9
- Pages
- 2598-2603
- ISSN
- 0066-4804 (ISSN-L)
- 1098-6596
- OpenAlex
- W2146370566
- Cited by
- 228
- References
- 1
- FWCI
- 3.20
- Type
- journal article
- Language
- en
- Open access
- green
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- Poirel, L., Weldhagen, G. F., Naas, T., De Champs, C., Dove, M. G., & Nordmann, P. (2001). GES-2, a Class A β-Lactamase from Pseudomonas aeruginosa with Increased Hydrolysis of Imipenem. Antimicrobial Agents and Chemotherapy. https://doi.org/10.1128/aac.45.9.2598-2603.2001
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