Genotypesof Pneumocystis jiroveci Isolates Obtained in Harare,Zimbabwe, and London, UnitedKingdom
Open accessAbstract
Isolates of Pneumocystis jiroveci from sulfa-exposed and nonexposed patients from London, United Kingdom, and Harare, Zimbabwe, were genotyped. At the dihydropteroate synthase (DHPS) locus, there was evidence of selection pressure from sulfa drug exposure, and reversal of DHPS genotype ratios occurred when selection pressure was absent or was removed.
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Another study demonstrated an apparent reversal of the DHPS mutant-to-wild-type ratios after the use of TMP-SMX was restricted.
“Another study demonstrated an apparent reversal of the DHPS mutant-to-wild-type ratios after the use of TMP-SMX was restricted (31).”
From Dihydropteroate Synthase Gene Mutations in<i>Pneumocystis</i>and Sulfa Resistance (2004) · cites this paper as [31]
Cites
Beard, C. B., Carter, J. L., Keely, S. P., Huang, L., Pieniazek, N. J., Moura, I. N. S., Roberts, J. M., Hightower, A. W., Bens, M. S., Freeman, A. R., et al. (2000) · Emerging infectious diseases · doi:10.3201/eid0603.000306 · Cited by 241 · see citing works
Ma, L., Borio, L., Masur, H., & Kovacs, J. A. (1999) · The Journal of Infectious Diseases · doi:10.1086/315148 · Cited by 169 · see citing works
Kazanjian, P., Armstrong, W., Hossler, P. A., Burman, W., Richardson, J., Lee, C., Crane, L., Katz, J., & Meshnick, S. R. (2000) · The Journal of Infectious Diseases · doi:10.1086/315719 · Cited by 164 · see citing works
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Dihydropteroate Synthase Gene Mutations in<i>Pneumocystis</i>and Sulfa Resistance
Huang, L., Crothers, K., Atzori, C., Benfield, T., Miller, R., Rabodonirina, M., & Helweg-Larsen, J. (2004) · Emerging Infectious Diseases · doi:10.3201/eid1010.030994 · Cited by 131 · see citing works
“Another study demonstrated an apparent reversal of the DHPS mutant-to-wild-type ratios after the use of TMPSMX was restricted (31).”
BackgroundSelf-citation
- Authors
- Miller, R. F., Lindley, A. R., Ambrose, H. E., Malin, A. S., & Wakefield, A. E.
- Affiliations
- The Royal Free Hospital (GB)
- University of Oxford (GB)
- University of Zimbabwe (ZW)
- Corresponding author
- Miller, Robert F.
- ORCID
- Miller, Robert F.
- Venue
- Antimicrobial Agents and Chemotherapy
- Publisher
- American Society for Microbiology
- Published
- 2003-12
- Volume
- 47
- Issue
- 12
- Pages
- 3979-3981
- ISSN
- 0066-4804 (ISSN-L)
- 1098-6596
- PMC
- PMC296206
- OpenAlex
- W2119371763
- Cited by
- 48
- References
- 3
- Citations by year
- 2024: 1 · 2021: 2 · 2020: 2 · 2018: 2 · 2017: 1 · 2016: 2 · 2015: 2 · 2014: 2 · 2013: 1 · 2012: 4
- FWCI
- 3.76
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Antimicrobial Agents and Chemotherapy (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Pneumocystis jirovecii pneumonia detection and treatment
- Health Sciences › Medicine › Epidemiology › Pneumonia and Respiratory Infections
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
- Keywords
- Pneumocystis jirovecii, genotyping, dihydropteroate synthase, selection pressure, drug resistance, Pneumocystis carinii pneumonia, Zimbabwe, London
- MeSH terms
- Genotype, United Kingdom, Humans, London, Mycoses, Pneumocystis, RNA, Ribosomal, RNA, Viral, Zimbabwe, HIV-1, HIV Infections, Trimethoprim, Sulfamethoxazole Drug Combination, Pneumocystis Infections, Reverse Transcriptase Polymerase Chain Reaction
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