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Caspofungin Resistance in Candida albicans: Correlating Clinical Outcome with Laboratory Susceptibility Testing of Three Isogenic Isolates Serially Obtained from a Patient with Progressive Candida Esophagitis
Open accessAbstract
A patient with azole-refractory thrush-esophagitis responded initially to caspofungin, but the treatment eventually failed. In a murine model, caspofungin was effective against two early isolates for which the MICs of caspofungin were low, but it was less effective against a late isolate for which the MIC of caspofungin was greater. We concluded that there is a correlation between in vivo failure and rising in vitro caspofungin MICs.
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“However, reports of echinocandin resistance in patients with infections due to C. albicans, C. glabrata, C. tropicalis, and C. krusei are rising [111–116].”
From Candida Infections, Causes, Targets, and Resistance Mechanisms: Traditional and Alternative Antifungal Agents (2013) · cites this paper as [111]
In the citing paper
“Likewise, the frequency of diagnostic test ordering, especially of blood cultures, and the type of blood culture systems employed may also impact the incidence rates in laboratory-based surveillance (106, 259).”
From Epidemiology of Invasive Candidiasis: a Persistent Public Health Problem (2007) · cites this paper as [106]
In the citing paper
“Although most surveillance studies have not specifically addressed the issue of differences among blood culture systems in the isolation of Candida species from blood, the isolation of C. glabrata may be increased in some blood culture systems (BacT/Alert versus BACTEC 9240) and in some blood culture media (BACTEC Mycosis IC/F versus BACTEC Plus Aerobic/F medium) over that observed in others (106,”
From Epidemiology of Invasive Candidiasis: a Persistent Public Health Problem (2007) · cites this paper as [106]
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Metadata
- Authors
- Hernandez, S., López-Ribot, J. L., Najvar, L. K., McCarthy, D. I., Bocanegra, R., & Graybill, J. R.
- Affiliations
- Department of Medicine, Division Infectious Diseases (7881)
- The University of Texas at San Antonio Health Science Center (US)
- Corresponding author
- Hernandez, Steve
- Venue
- Antimicrobial Agents and Chemotherapy
- Publisher
- American Society for Microbiology
- Published
- 2004-04
- Volume
- 48
- Issue
- 4
- Pages
- 1382-1383
- ISSN
- 0066-4804 (ISSN-L)
- 1098-6596
- PMC
- PMC375251
- OpenAlex
- W2133731564
- Cited by
- 162
- References
- 15
- Citations by year
- 2024: 1 · 2023: 2 · 2022: 3 · 2021: 4 · 2020: 1 · 2019: 3 · 2018: 2 · 2017: 2 · 2016: 3 · 2015: 3 · 2014: 2 · 2013: 8 · 2012: 9
- FWCI
- 13.12
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Antimicrobial Agents and Chemotherapy (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Fungal Plant Pathogen Control
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Keywords
- caspofungin resistance, Candida albicans, serial isolates, minimum inhibitory concentration, antifungal susceptibility testing, clinical outcomes, mouse model, treatment failure
- MeSH terms
- Caspofungin, Acquired Immunodeficiency Syndrome, Adult, Animals, Antifungal Agents, Candida albicans, Candidiasis, Esophagitis, Humans, Male, Mice, Inbred ICR, Microbial Sensitivity Tests, Peptides, Peptides, Cyclic, Treatment Failure, Drug Resistance, Fungal, Mice, Echinocandins, Lipopeptides
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