Emergence of a Candida krusei Isolate with Reduced Susceptibility to Caspofungin during Therapy
Open accessAbstract
Clinical failure associated with reduced susceptibility to caspofungin has been described in Candida albicans and C. parapsilosis . We report a case of Candida krusei infection that progressed despite caspofungin therapy. Reduced microbial susceptibility to all three echinocandins (caspofungin, anidulafungin, and micafungin) was noted but was not associated with mutations in FKS1 .
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Reports of echinocandin resistance in patients with infections due to C. albicans, C. glabrata, C. tropicalis, and C. krusei are rising.
“However, reports of echinocandin resistance in patients with infections due to C. albicans, C. glabrata, C. tropicalis, and C. krusei are rising [111–116].”
From <i>Candida</i>Infections, Causes, Targets, and Resistance Mechanisms: Traditional and Alternative Antifungal Agents (2013) · cites this paper as [113]
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- Authors
- Hakki, M., Staab, J. F., & Marr, K. A.
- Affiliations
- University of Washington (US)
- Fred Hutch Cancer Center (US)
- Corresponding author
- Marr, Kieren A.
- Venue
- Antimicrobial Agents and Chemotherapy
- Publisher
- American Society for Microbiology
- Published
- 2006-07
- Volume
- 50
- Issue
- 7
- Pages
- 2522-2524
- ISSN
- 0066-4804 (ISSN-L)
- 1098-6596
- OpenAlex
- W2109890308
- Cited by
- 148
- References
- 10
- Citations by year
- 2025: 2 · 2024: 2 · 2023: 1 · 2022: 2 · 2021: 2 · 2020: 4 · 2019: 4 · 2018: 4 · 2017: 4 · 2016: 2 · 2015: 7 · 2014: 11 · 2013: 5 · 2012: 9
- FWCI
- 13.36
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Antimicrobial Agents and Chemotherapy (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Fungal Plant Pathogen Control
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Yeasts and Rust Fungi Studies
- Keywords
- Candida krusei, caspofungin, reduced susceptibility, echinocandin resistance, anidulafungin, micafungin, FKS1, antifungal treatment failure, fungal infection
- MeSH terms
- Caspofungin, Adult, Antifungal Agents, Candida, Candidiasis, Oral, Female, Humans, Microbial Sensitivity Tests, Endophthalmitis, Peptides, Cyclic, Fungemia, Drug Resistance, Fungal, Echinocandins, Lipopeptides
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