In Vitro Killing of Mycobacterium ulcerans by Acidified Nitrite
Open accessAbstract
Mycobacterium ulcerans, which causes Buruli ulcer, was exposed to acidified nitrite or to acid alone for 10 or 20 min. Killing was rapid, and viable counts were reduced below detectable limits within 10 min of exposure to 40 mM acidified nitrite. M. ulcerans is highly susceptible to acidified nitrite in vitro.
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Acidified nitrite exhibits bactericidal action against several pathogens in other tissue compartments including the skin, dental caries, and gastric mucosa.
“Acidified nitrite also exhibits bactericidal action against several pathogens in other tissue compartments including the skin, dental caries, and gastric mucosa [201–206].”
From Inorganic nitrite therapy: historical perspective and future directions (2011) · cites this paper as [202]
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- Authors
- Phillips, R., Kuijper, S., Benjamin, N., Wansbrough-Jones, M., Wilks, M., & Kolk, A. H. J.
- Affiliations
- St George's, University of London (GB)
- Royal Tropical Institute (NL)
- University of Exeter (GB)
- St Bartholomew's Hospital (GB)
- Venue
- Antimicrobial Agents and Chemotherapy
- Publisher
- American Society for Microbiology
- Published
- 2004-08
- Volume
- 48
- Issue
- 8
- Pages
- 3130-3132
- ISSN
- 0066-4804 (ISSN-L)
- 1098-6596
- PMC
- PMC478540
- OpenAlex
- W2112203950
- Cited by
- 43
- References
- 23
- Citations by year
- 2023: 1 · 2022: 1 · 2021: 4 · 2020: 2 · 2019: 2 · 2018: 2 · 2017: 2 · 2016: 6 · 2015: 2 · 2014: 2 · 2013: 1 · 2012: 3
- FWCI
- 1.44
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Antimicrobial Agents and Chemotherapy (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Mycobacterium research and diagnosis
- Health Sciences › Medicine › Infectious Diseases › Tuberculosis Research and Epidemiology
- Health Sciences › Medicine › Epidemiology › Burkholderia infections and melioidosis
- Keywords
- Mycobacterium ulcerans, Buruli ulcer, bacterial killing, acid exposure, antimicrobial susceptibility, nitrite
- MeSH terms
- Acids, Humans, Microbial Sensitivity Tests, Mycobacterium Infections, Nitrites, Nitrogen Oxides, Colony Count, Microbial, Mycobacterium ulcerans
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