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Effect of Probenecid on Cerebrospinal Fluid Concentrations of Penicillin and Cephalosporin Derivatives
Open accessAbstract
Probenecid may elevate the cerebrospinal fluid (CSF) concentration of penicillin G by inhibiting the excretion of organic acids from CSF. We have studied this phenomenon with various penicillin and cephalosporin derivatives. Penicillin concentrations were determined in rabbits under steady-state conditions before and after intravenous probenecid administration. With both low-dose and high-dose probenecid, CSF penicillin levels increased two to three times as did CSF concentration as a percentage of serum level. The same probenecid effect was consistently demonstrated in animals with experimental pneumococcal meningitis. Probenecid likewise increased the CSF concentration of ampicillin, carbenicillin, nafcillin, cephacatrile, and cefazolin. Probenecid may prove useful in certain bacterial infections where high CSF antibiotic levels are necessary.
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Cited by
The Induction of Meningeal Inflammation by Components of the Pneumococcal Cell Wall
Tuomanen, E., Liu, H., Hengstler, B., Zak, O., & Tomasz, A. (1985) · Journal of Infectious Diseases · doi:10.1093/infdis/151.5.859 · Cited by 355
Heumann, D., Barras, C., Severin, A., Glauser, M. P., & Tomasz, A. (1994) · Infection and Immunity · doi:10.1128/iai.62.7.2715-2721.1994 · Cited by 336
Host–pathogen interactions in bacterial meningitis.
Doran, K. S., Fulde, M., Gratz, N., Kim, B. J., Nau, R., Prasadarao, N., Schubert-Unkmeir, A., Tuomanen, E. I., & Valentin-Weigand, P. (2016) · Acta Neuropathologica · doi:10.1007/s00401-015-1531-z · Cited by 208
Metadata
- Authors
- Dacey, R. G., & Sande, M. A.
- Venue
- Antimicrobial Agents and Chemotherapy
- Publisher
- American Society for Microbiology
- Published
- 1974-10
- Volume
- 6
- Issue
- 4
- Pages
- 437-441
- ISSN
- 0066-4804 (ISSN-L)
- 1098-6596
- OpenAlex
- W2075857379
- Cited by
- 287
- References
- 0
- FWCI
- 1.92
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Effect of Probenecid on Cerebrospinal Fluid Concentrations of Penicillin and Cephalosporin Derivatives. https://app.cochat.ai/papers/10.1128/aac.6.4.437
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- Dacey, R. G., & Sande, M. A. (1974). Effect of Probenecid on Cerebrospinal Fluid Concentrations of Penicillin and Cephalosporin Derivatives. Antimicrobial Agents and Chemotherapy. https://doi.org/10.1128/aac.6.4.437
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
