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The Microbiota of Breast Tissue and Its Association with Breast Cancer
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UNLABELLED: In the United States, 1 in 8 women will be diagnosed with breast cancer in her lifetime. Along with genetics, the environment contributes to disease development, but what these exact environmental factors are remains unknown. We have previously shown that breast tissue is not sterile but contains a diverse population of bacteria. We thus believe that the host's local microbiome could be modulating the risk of breast cancer development. Using 16S rRNA amplicon sequencing, we show that bacterial profiles differ between normal adjacent tissue from women with breast cancer and tissue from healthy controls. Women with breast cancer had higher relative abundances of Bacillus, Enterobacteriaceae and Staphylococcus Escherichia coli (a member of the Enterobacteriaceae family) and Staphylococcus epidermidis, isolated from breast cancer patients, were shown to induce DNA double-stranded breaks in HeLa cells using the histone-2AX (H2AX) phosphorylation (γ-H2AX) assay. We also found that microbial profiles are similar between normal adjacent tissue and tissue sampled directly from the tumor. This study raises important questions as to what role the breast microbiome plays in disease development or progression and how we can manipulate this for possible therapeutics or prevention. IMPORTANCE: This study shows that different bacterial profiles in breast tissue exist between healthy women and those with breast cancer. Higher relative abundances of bacteria that had the ability to cause DNA damage in vitro were detected in breast cancer patients, as was a decrease in some lactic acid bacteria, known for their beneficial health effects, including anticarcinogenic properties. This study raises important questions as to the role of the mammary microbiome in modulating the risk of breast cancer development.
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“However, other studies have indeed shown cultivable bacteria in breast (127–129), lung (18), prostate (130, 131), pancreas (14, 15), and colon cancers (19, 132)”
From The microbiome and human cancer (2021) · cites this paper as [128]
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QIIME allows analysis of high-throughput community sequencing data
Caporaso, J. G., Kuczynski, J., Stombaugh, J., Bittinger, K., Bushman, F. D., Costello, E. K., Fierer, N., Peña, A. G., Goodrich, J. K., Gordon, J. I., et al. (2010) · Nature Methods · doi:10.1038/nmeth.f.303 · Cited by 34,887
Search and clustering orders of magnitude faster than BLAST
Edgar, R. C. (2010) · Bioinformatics · doi:10.1093/bioinformatics/btq461 · Cited by 21,098
MUSCLE: a multiple sequence alignment method with reduced time and space complexity
Edgar, R. C. (2004) · BMC Bioinformatics · doi:10.1186/1471-2105-5-113 · Cited by 9,119
UniFrac: a New Phylogenetic Method for Comparing Microbial Communities
Lozupone, C., & Knight, R. (2005) · Applied and Environmental Microbiology · doi:10.1128/aem.71.12.8228-8235.2005 · Cited by 8,227
A core gut microbiome in obese and lean twins
Turnbaugh, P. J., Hamady, M., Yatsunenko, T., Cantarel, B. L., Duncan, A., Ley, R. E., Sogin, M. L., Jones, W. J., Roe, B. A., Affourtit, J. P., et al. (2009) · Nature · doi:10.1038/nature07540 · Cited by 7,823
Pruesse, E., Quast, C., Knittel, K., Fuchs, B. M., Ludwig, W., Peplies, J., & Glöckner, F. O. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkm864 · Cited by 6,682
FastTree: Computing Large Minimum Evolution Trees with Profiles instead of a Distance Matrix
Price, M. N., Dehal, P. S., & Arkin, A. P. (2009) · Molecular Biology and Evolution · doi:10.1093/molbev/msp077 · Cited by 5,602
Frank, D. N., St. Amand, A. L., Feldman, R. A., Boedeker, E. C., Harpaz, N., & Pace, N. R. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0706625104 · Cited by 4,611
The Statistical Analysis of Compositional Data
Aitchison, J. (1986) · doi:10.1007/978-94-009-4109-0 · Cited by 4,383
The Statistical Analysis of Compositional Data
Piepel, G. F., & Aitchison, J. (1988) · Technometrics · doi:10.2307/1270335 · Cited by 3,451
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Items 101–200 of 631
Toll Like Receptors as Sensors of the Tumor Microbial Dysbiosis: Implications in Cancer Progression
Noci, V. L., Bernardo, G., Bianchi, F., Tagliabue, E., Sommariva, M., & Sfondrini, L. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.732192 · Cited by 60
Crosstalk between autophagy and microbiota in cancer progression
Wang, Y., Du, J., Wu, X., Abdelrehem, A., Ren, Y., Liu, C., Zhou, X., & Wang, S. (2021) · Molecular Cancer · doi:10.1186/s12943-021-01461-0 · Cited by 61
Significance of human microbiome in breast cancer: Tale of an invisible and an invincible
Chadha, J., Nandi, D., Atri, Y., & Nag, A. (2020) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2020.07.010 · Cited by 60
Microbiome dysbiosis and epigenetic modulations in lung cancer: From pathogenesis to therapy
Khan, F. H., Bhat, B. A., Sheikh, B. A., Tariq, L., Padmanabhan, R., Verma, J. P., Shukla, A. C., Dowlati, A., & Abbas, A. (2021) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2021.07.005 · Cited by 59
The role of the bacterial microbiome in the treatment of cancer
Yu, Z., Xie, R., You, R., Liu, Y., Chen, X.-Y., Chen, M., & Huang, P.-Y. (2021) · BMC Cancer · doi:10.1186/s12885-021-08664-0 · Cited by 57
The intratumoral microbiome: Characterization methods and functional impact
Heymann, C. J. F., Bard, J., Heymann, M., Heymann, D., & Bobin‐Dubigeon, C. (2021) · Cancer Letters · doi:10.1016/j.canlet.2021.09.009 · Cited by 60
S-Nitrosylation in Tumor Microenvironment
Sharma, V., Fernando, V., Letson, J., Walia, Y., Zheng, X., Fackelman, D., & Furuta, S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22094600 · Cited by 59
Role of the Microbiota in Lung Cancer: Insights on Prevention and Treatment
Pizzo, F., Maroccia, Z., Ferri, I. H., & Fiorentini, C. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23116138 · Cited by 60
Su, J., Lin, X., Li, D., Yang, C.-M., Lv, S., Chen, X., Yang, X., Pan, B., Xu, R. P., Ren, L., et al. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2347757 · Cited by 59
Intratumoral Microbiota as a Target for Advanced Cancer Therapeutics
Peng, F., Hu, M., Su, Z., Hu, L., Guo, L., & Yang, K. (2024) · Advanced Materials · doi:10.1002/adma.202405331 · Cited by 57
Role of Gut Microbiota in Breast Cancer and Drug Resistance
Sathiyapriya, V., Parida, S., Lingipilli, B. T., Ramalingam, K., Podipireddy, D. R., & Muniraj, N. (2023) · Pathogens · doi:10.3390/pathogens12030468 · Cited by 57
The microbiome(s) and cancer: know thy neighbor(s)
González‐Sánchez, P., & DeNicola, G. M. (2021) · The Journal of Pathology · doi:10.1002/path.5661 · Cited by 57
The critical role of tumor microbiome in cancer immunotherapy
Yang, L., Wang, Q., He, L., & Sun, X. (2024) · Cancer Biology & Therapy · doi:10.1080/15384047.2024.2301801 · Cited by 54
Analysis of Gut Microbiota in Patients with Breast Cancer and Benign Breast Lesions
Ma, Z., Qu, M., & Wang, X. (2022) · Polish Journal of Microbiology · doi:10.33073/pjm-2022-019 · Cited by 54
Common Core Bacterial Biomarkers of Bladder Cancer Based on Multiple Datasets
Mai, G., Chen, L., Li, R., Liu, Q., Zhang, H., & Ma, Y. (2019) · BioMed Research International · doi:10.1155/2019/4824909 · Cited by 54
Montanari, E., Bernardo, G., Noci, V. L., Anselmi, M., Pupa, S. M., Tagliabue, E., Sommariva, M., & Sfondrini, L. (2025) · Molecular Cancer · doi:10.1186/s12943-025-02348-0 · Cited by 65
The onco-immunological implications of Fusobacterium nucleatum in breast cancer
van der Merwe, M., van Niekerk, G., Botha, A., & Engelbrecht, A. (2021) · Immunology Letters · doi:10.1016/j.imlet.2021.02.007 · Cited by 54
Arnone, A. A., & Cook, K. L. (2022) · Endocrinology · doi:10.1210/endocr/bqac177 · Cited by 53
Komorowski, A. S., & Pezo, R. C. (2019) · Breast Cancer Research and Treatment · doi:10.1007/s10549-019-05472-w · Cited by 55
Can we modulate the breastfed infant gut microbiota through maternal diet?
Sindi, A. S., Geddes, D. T., Wlodek, M. E., Mühlhäusler, B. S., Payne, M. S., & Stinson, L. F. (2021) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuab011 · Cited by 55
Modulating Microbiota as a New Strategy for Breast Cancer Prevention and Treatment
Wu, H., Ganguly, S., & Tollefsbol, T. O. (2022) · Microorganisms · doi:10.3390/microorganisms10091727 · Cited by 53
Intratumoral bacteria are an important “accomplice” in tumor development and metastasis
Wang, G., He, X., & Wang, Q. (2022) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2022.188846 · Cited by 51
Parida, S., Siddharth, S., Xia, Y., & Sharma, D. (2023) · npj Breast Cancer · doi:10.1038/s41523-023-00505-6 · Cited by 52
Human gut, breast, and oral microbiome in breast cancer: A systematic review and meta-analysis
Thu, M. S., Chotirosniramit, K., Nopsopon, T., Hirankarn, N., & Pongpirul, K. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1144021 · Cited by 54
In situ biomolecule production by bacteria; a synthetic biology approach to medicine
Bueso, Y. F., Lehouritis, P., & Tangney, M. (2018) · Journal of Controlled Release · doi:10.1016/j.jconrel.2018.02.023 · Cited by 51
Self-citationJiang, S., Ma, W., Ma, C., Zhang, Z., Zhang, W., & Zhang, J. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2341717 · Cited by 52
Kovàcs, T., Mikó, E., Ujlaki, G., Yousef, H., Csontos, V., Uray, K., & Bai, P. (2021) · Cancer and Metastasis Reviews · doi:10.1007/s10555-021-10013-3 · Cited by 52
Advances of bacteria-based delivery systems for modulating tumor microenvironment
Li, S., Yue, H., Wang, S., Li, X., Wang, X., Guo, P., Ma, G., & Wei, W. (2022) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2022.114444 · Cited by 50
Filippou, C., Themistocleous, S., Marangos, G., Panayiotou, Y., Fyrilla, M., Kousparou, C. A., Pana, Z. D., Tsioutis, C., Johnson, E. O., & Yiallouris, A. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25021110 · Cited by 49
Tumor microbiome: roles in tumor initiation, progression, and therapy
Zhang, S., Huang, J., Jiang, Z., Tong, H., Ma, X., & Liu, Y. (2025) · Molecular Biomedicine · doi:10.1186/s43556-025-00248-9 · Cited by 58
Zhao, F., An, R., Ma, Y., Yu, S., Gao, Y., Wang, Y., Yu, H., Xie, X., & Zhang, J. (2025) · Clinical and Translational Medicine · doi:10.1002/ctm2.70273 · Cited by 50
Okubo, R., Kinoshita, T., Katsumata, N., Uezono, Y., Xiao, J., & Matsuoka, Y. (2019) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2019.02.025 · Cited by 51
The Microbiome and Cancer: Creating Friendly Neighborhoods and Removing the Foes Within
Parida, S., & Sharma, D. (2020) · Cancer Research · doi:10.1158/0008-5472.can-20-2629 · Cited by 51
Kabwe, M., Dashper, S. G., Bachrach, G., & Tucci, J. (2021) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuab017 · Cited by 52
Newman, T. M., Vitolins, M. Z., & Cook, K. L. (2019) · Nutrients · doi:10.3390/nu11112565 · Cited by 49
Li, Y., Dong, B., Wu, W., Wang, J., Jin, H., Chen, K., Huang, K., Huang, S., & Yao, Y. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.865121 · Cited by 48
Fu, Y., Li, J., Cai, W., Huang, Y., Liu, X., Ma, Z., Tang, Z., Bian, X., Zheng, J., Jiang, J., et al. (2024) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2023.11.018 · Cited by 48
Dual Role of Bacteria in Carcinoma: Stimulation and Inhibition
Al-Hilu, S. A., & Al-Shujairi, W. H. (2020) · International Journal of Microbiology · doi:10.1155/2020/4639761 · Cited by 48
Singla, R. K., Wang, X., Gundamaraju, R., Joon, S., Tsagkaris, C., Behzad, S., Khan, J., Gautam, R. K., Goyal, R., Rakmai, J., et al. (2022) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2022.2097196 · Cited by 52
Functional biotransformation of phytoestrogens by gut microbiota with impact on cancer treatment
Farhat, E. K., Sher, E. K., Džidić-Krivić, A., Banjari, I., & Sher, F. (2023) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2023.109368 · Cited by 48
Association between the microbiota and women’s cancers – Cause or consequences?
Alizadehmohajer, N., Shojaeifar, S., Nedaeinia, R., Esparvarinha, M., Mohammadi, F., Ferns, G. A., Ghayour‐Mobarhan, M., Manian, M., & Balouchi, A. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.110203 · Cited by 47
Exploring the Potential of Breast Microbiota as Biomarker for Breast Cancer and Therapeutic Response
Dieleman, S., Aarnoutse, R., Ziemons, J., Kooreman, L. F. S., Boleij, A., & Smidt, M. L. (2021) · American Journal Of Pathology · doi:10.1016/j.ajpath.2021.02.020 · Cited by 48
Dumont-Leblond, N., Veillette, M., Racine, C., Joubert, P., & Duchaine, C. (2021) · PLoS ONE · doi:10.1371/journal.pone.0249832 · Cited by 49
Cross-talk between cancer and Pseudomonas aeruginosa mediates tumor suppression
Choi, J. K., Naffouje, S. A., Goto, M., Wang, J., Christov, K. T., Rademacher, D. J., Green, A., Stecenko, A. A., Chakrabarty, A. M., Gupta, T. K. D., et al. (2023) · Communications Biology · doi:10.1038/s42003-022-04395-5 · Cited by 46
Comparison of the Gut Microbiota in Patients with Benign and Malignant Breast Tumors: A Pilot Study
Yang, P., Wang, Z., Peng, Q., Lian, W., & Chen, D. (2021) · Evolutionary Bioinformatics · doi:10.1177/11769343211057573 · Cited by 47
The breast tissue microbiome, stroma, immune cells and breast cancer
Hieken, T. J., Chen, J., Chen, B., Johnson, S. P., Hoskin, T. L., Degnim, A. C., Walther-Antonio, M. R. S., & Chia, N. (2022) · Neoplasia · doi:10.1016/j.neo.2022.100786 · Cited by 45
The Relationship Between Microbial Community and Breast Cancer
Song, X., Wei, C., & Li, X. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.849022 · Cited by 45
The conundrum of breast cancer and microbiome - A comprehensive review of the current evidence
Papakonstantinou, A., Nuciforo, P. G., Borrell, M., Zamora, E., Pimentel, I., Saura, C., & Oliveira, M. (2022) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2022.102470 · Cited by 45
Pan-cancer atlas of tumor-resident microbiome, immunity and prognosis
Sheng, D., Jin, C., Yue, K., Yue, M., Liang, Y., Xue, X., Li, P., Zhao, G., & Zhang, L. (2024) · Cancer Letters · doi:10.1016/j.canlet.2024.217077 · Cited by 46
T-cell-based breast cancer immunotherapy
Pilipow, K., Darwich, A., & Losurdo, A. (2020) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2020.05.019 · Cited by 44
Microbiome Assisted Tumor Microenvironment: Emerging Target of Breast Cancer
Malla, R. R., Marni, R., Kumari, S., Chakraborty, A., & Pappu, L. (2021) · Clinical Breast Cancer · doi:10.1016/j.clbc.2021.09.002 · Cited by 44
Hoskinson, C., Zheng, K., Gabel, J., Kump, A., German, R., Podicheti, R., Marino, N., & Stiemsma, L. T. (2022) · mSystems · doi:10.1128/msystems.01489-21 · Cited by 42
Microbiota composition in bilateral healthy breast tissue and breast tumors
Klann, E. M., Williamson, J. M., Tagliamonte, M. S., Ukhanova, M., Asirvatham, J. R., Chim, H., Yaghjyan, L., & Mai, V. (2020) · Cancer Causes & Control · doi:10.1007/s10552-020-01338-5 · Cited by 42
Characterizing the breast cancer lipidome and its interaction with the tissue microbiota
Giallourou, N., Urbaniak, C., Puebla-Barragan, S., Vorkas, P. A., Swann, J. R., & Reid, G. (2021) · Communications Biology · doi:10.1038/s42003-021-02710-0 · Cited by 42
Self-citationInteraction of Gut Microbiota with Endocrine Homeostasis and Thyroid Cancer
Liu, Q., Sun, W., & Zhang, H. (2022) · Cancers · doi:10.3390/cancers14112656 · Cited by 43
Emerging Role of Gut Microbiota in Breast Cancer Development and Its Implications in Treatment
Mir, R., Albarqi, S., Albalawi, W., Alatwi, H. E., Alatawy, M., Bedaiwi, R. I., Almotairi, R., Husain, E., Zubair, M., Alanazi, G. B., et al. (2024) · Metabolites · doi:10.3390/metabo14120683 · Cited by 41
Zumwalde, N. A., Haag, J. D., Gould, M. N., & Gumperz, J. E. (2018) · Breast Cancer Research · doi:10.1186/s13058-018-1036-5 · Cited by 41
Host Microbe Interactions in the Lactating Mammary Gland
Sakwińska, O., & Bosco, N. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.01863 · Cited by 43
The promise and challenge of cancer microbiome research
Manzoor, S. S., Doedens, A. M., & Burns, M. B. (2020) · Genome biology · doi:10.1186/s13059-020-02037-9 · Cited by 42
Hadžega, D., Minárik, G., Karaba, M., Kaľavská, K., Benca, J., Čierniková, S., Sedláčková, T., Nemcova, P., Boháč, M., Pinďák, D., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22169058 · Cited by 38
The influence of the commensal microbiota on distal tumor-promoting inflammation
Rosean, C. M. B., & Rutkowski, M. R. (2017) · Seminars in Immunology · doi:10.1016/j.smim.2017.06.002 · Cited by 40
Yadav, M., Kapoor, A., Verma, A., & Ambatipudi, K. (2022) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.2c00335 · Cited by 37
Bacteria and tumor: Understanding the roles of bacteria in tumor genesis and immunology
Zhao, M., Chen, X., Yang, Z., Yang, X., & Peng, Q. (2022) · Microbiological Research · doi:10.1016/j.micres.2022.127082 · Cited by 38
Reconstitution and Transmission of Gut Microbiomes and Their Genes between Generations
Rosenberg, E., & Zilber-Rosenberg, I. (2021) · Microorganisms · doi:10.3390/microorganisms10010070 · Cited by 38
Parida, S., Siddharth, S., Gatla, H. R., Wu, S., Wang, G., Gabrielson, K. L., Sears, C. L., Ladle, B. H., & Sharma, D. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1194931 · Cited by 37
Elkins, J. M., Kates, S. L., Lange, J. K., Lange, J., Lichstein, P. M., Otero, J. E., Soriano, À., Wagner, C., & Wouthuyzen‐Bakker, M. (2018) · The Journal of Arthroplasty · doi:10.1016/j.arth.2018.09.069 · Cited by 37
Exosomes as a storehouse of tissue remodeling proteases and mediators of cancer progression
Das, A., Mohan, V., Krishnaswamy, V. R., Solomonov, I., & Sagi, I. (2019) · Cancer and Metastasis Reviews · doi:10.1007/s10555-019-09813-5 · Cited by 37
Bidirectional Functional Effects of Staphylococcus on Carcinogenesis
Wei, Y., Sandhu, E., Yang, X., Yang, J., Ren, Y., & Gao, X. (2022) · Microorganisms · doi:10.3390/microorganisms10122353 · Cited by 37
E. coli Secretome Metabolically Modulates MDA-MB-231 Breast Cancer Cells’ Energy Metabolism
AlMalki, R. H., Sebaa, R., Al‐Ansari, M. M., Al-Alwan, M. M., Alwehaibi, M. A., & Rahman, A. M. A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24044219 · Cited by 36
Chen, F., Yang, J., Guo, Y., Su, D., Sheng, Y., & Wu, Y. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1140995 · Cited by 38
Wilkie, T., Verma, A. K., Zhao, H., Charan, M., Ahirwar, D. K., Kant, S., Pancholi, V., Mishra, S., & Ganju, R. K. (2021) · Molecular Oncology · doi:10.1002/1878-0261.12975 · Cited by 36
BIC: a database for the transcriptional landscape of bacteria in cancer
Chen, K.-P., Hsu, C., Oyang, Y., Huang, H., & Juan, H. (2022) · Nucleic Acids Research · doi:10.1093/nar/gkac891 · Cited by 35
Huang, Q., Wei, X., Li, W., Ma, Y., Chen, G., Zhao, L., Jiang, Y., Xie, S., Chen, Q., & Chen, T. (2022) · Cancers · doi:10.3390/cancers14215178 · Cited by 36
Mani, S. (2017) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2017.07.004 · Cited by 35
Minárovits, J. (2020) · Anaerobe · doi:10.1016/j.anaerobe.2020.102300 · Cited by 35
Microbial dysbiosis and epigenetics modulation in cancer development – A chemopreventive approach
Haque, S., Raina, R., Afroze, N., Hussain, A., Alsulimani, A., Singh, V., Mishra, B. N., Kaul, S., & Kharwar, R. N. (2021) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2021.06.024 · Cited by 35
Wang, N., Yang, J., Han, W., Han, M., Liu, X., Jiang, L., Cao, H., Jing, M., Sun, T., & Xu, J. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.1029905 · Cited by 35
Philley, J. V., Kannan, A., Olusola, P., McGaha, P. K., Singh, K. P., Samten, B., Griffith, D. E., & Dasgupta, S. (2019) · Cellular Physiology and Biochemistry · doi:10.33594/000000020 · Cited by 34
The Efficacy of Breast Implant Irrigant Solutions: A Comparative Analysis Using an In Vitro Model
Ngaage, L. M., Elegbede, A. I., Brao, K. J., Chopra, K., Gowda, A. U., Nam, A. J., Ernst, R. K., Shirtliff, M. E., Harro, J. M., & Rasko, Y. M. (2020) · Plastic & Reconstructive Surgery · doi:10.1097/prs.0000000000007028 · Cited by 34
Greville, G., Llop, E., Huang, C., Creagh-Flynn, J., Pfister, S., O’Flaherty, R., Madden, S. F., Peracaula, R., Rudd, P. M., McCann, A. H., et al. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.01218 · Cited by 35
Gonçalves, M. F. M., Pina‐Vaz, T., Fernandes, Â. R., Miranda, I. M., Silva, C., Rodrigues, A. G., & Lisboa, C. (2023) · Cancers · doi:10.3390/cancers15051423 · Cited by 33
Bacterial live therapeutics for human diseases
Frutos-Grilo, E., Ana, Y., Miguel, J. G.-D., Cardona-I-Collado, M., Rodríguez-Arce, I., & Serrano, L. G. (2024) · Molecular Systems Biology · doi:10.1038/s44320-024-00067-0 · Cited by 36
Mai, Z., Fu, L., Su, J., To, K. K. W., Yang, C., & Xia, C. (2025) · Molecular Cancer · doi:10.1186/s12943-024-02202-9 · Cited by 35
The Gut Microbiome and Gastrointestinal Toxicities in Pelvic Radiation Therapy: A Clinical Review
Oh, B., Eade, T., Lamoury, G., Carroll, S. L., Morgia, M., Kneebone, A. B., Hruby, G., Stevens, M. J., Boyle, F. M., Clarke, S. J., et al. (2021) · Cancers · doi:10.3390/cancers13102353 · Cited by 34
Kim, H., Kim, J.-J., Maeng, S., Oh, B., Hwang, K., & Kim, B. S. (2021) · Journal of Microbiology and Biotechnology · doi:10.4014/jmb.2106.06039 · Cited by 33
The role played by bacterial infections in the onset and metastasis of cancer
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Fusobacterium nucleatum : a novel immune modulator in breast cancer?
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Metadata
- Authors
- Urbaniak, C., Gloor, G. B., Brackstone, M., Scott, L., Tangney, M., & Reid, G.
- Affiliations
- Western University (CA)
- London Regional Cancer Program, London, Ontario, Canada
- University College Cork (IE)
- Corresponding author
- Reid, Gregor
- Venue
- Applied and Environmental Microbiology
- Publisher
- American Society for Microbiology
- Published
- 2016-08-15
- Volume
- 82
- Issue
- 16
- Pages
- 5039-5048
- ISSN
- 0099-2240 (ISSN-L)
- 1098-5336
- PMC
- PMC4968547
- OpenAlex
- W2493607481
- Cited by
- 625
- References
- 53
- Citations by year
- 2026: 51 · 2025: 102 · 2024: 75 · 2023: 82 · 2022: 68 · 2021: 88 · 2020: 63 · 2019: 41 · 2018: 29 · 2017: 19 · 2016: 5
- FWCI
- 16.29
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Applied and Environmental Microbiology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Arrow@dit (Dublin Institute of Technology) (submittedVersion, cc-by)
- Cork Open Research Archive (University College Cork, Ireland) (submittedVersion, cc-by)
- Scholarship@Western (Western University) (submittedVersion)
- Funders
- Canadian Institutes of Health Research
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Life Sciences › Immunology and Microbiology › Microbiology › Reproductive tract infections research
- Keywords
- breast microbiome, breast cancer, bacterial diversity, adjacent normal tissue, tumor tissue, Bacillus, Enterobacteriaceae, Staphylococcus epidermidis, Escherichia coli, DNA double-strand breaks, H2AX phosphorylation, lactic acid bacteria, cancer risk, environmental factors
- MeSH terms
- Adult, Aged, Aged, 80 and over, Bacteria, Breast, Breast Neoplasms, Female, Humans, Middle Aged, Ontario, RNA, Ribosomal, 16S, Sequence Analysis, DNA, Young Adult, Microbiota
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