Cited by 631Gut microbiota and healthOral microbiology and periodontitis researchReproductive tract infections research

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The Microbiota of Breast Tissue and Its Association with Breast Cancer

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Urbaniak, Camilla, Gloor, Gregory B., Brackstone, Muriel, Scott, Leslie, Tangney, Mark, Reid, Gregor·2016·Applied and Environmental Microbiology

DOI 10.1128/aem.01235-16PMC PMC4968547

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Abstract

UNLABELLED: In the United States, 1 in 8 women will be diagnosed with breast cancer in her lifetime. Along with genetics, the environment contributes to disease development, but what these exact environmental factors are remains unknown. We have previously shown that breast tissue is not sterile but contains a diverse population of bacteria. We thus believe that the host's local microbiome could be modulating the risk of breast cancer development. Using 16S rRNA amplicon sequencing, we show that bacterial profiles differ between normal adjacent tissue from women with breast cancer and tissue from healthy controls. Women with breast cancer had higher relative abundances of Bacillus, Enterobacteriaceae and Staphylococcus Escherichia coli (a member of the Enterobacteriaceae family) and Staphylococcus epidermidis, isolated from breast cancer patients, were shown to induce DNA double-stranded breaks in HeLa cells using the histone-2AX (H2AX) phosphorylation (γ-H2AX) assay. We also found that microbial profiles are similar between normal adjacent tissue and tissue sampled directly from the tumor. This study raises important questions as to what role the breast microbiome plays in disease development or progression and how we can manipulate this for possible therapeutics or prevention. IMPORTANCE: This study shows that different bacterial profiles in breast tissue exist between healthy women and those with breast cancer. Higher relative abundances of bacteria that had the ability to cause DNA damage in vitro were detected in breast cancer patients, as was a decrease in some lactic acid bacteria, known for their beneficial health effects, including anticarcinogenic properties. This study raises important questions as to the role of the mammary microbiome in modulating the risk of breast cancer development.

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Retracted
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Authors: Urbaniak, C., Gloor, G. B., Brackstone, M., Scott, L., Tangney, M., & Reid, G.
Affiliations: Western University (CA)
London Regional Cancer Program, London, Ontario, Canada
University College Cork (IE)
Corresponding author: Reid, Gregor
ORCID: Urbaniak, Camilla
Gloor, Gregory B.
Brackstone, Muriel
Tangney, Mark
Reid, Gregor
Venue: Applied and Environmental Microbiology
Publisher: American Society for Microbiology
Published: 2016-08-15
Volume: 82
Issue: 16
Pages: 5039-5048
ISSN: 0099-2240 (ISSN-L)
1098-5336
DOI: 10.1128/aem.01235-16
PMC: PMC4968547
OpenAlex: W2493607481
Cited by: 625
References: 53
Citations by year: 2026: 51 · 2025: 102 · 2024: 75 · 2023: 82 · 2022: 68 · 2021: 88 · 2020: 63 · 2019: 41 · 2018: 29 · 2017: 19 · 2016: 5
FWCI: 16.29
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
journals.asm.org/non-commercial-tdm-license (tdm)
Locations: Applied and Environmental Microbiology (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
Arrow@dit (Dublin Institute of Technology) (submittedVersion, cc-by)
Cork Open Research Archive (University College Cork, Ireland) (submittedVersion, cc-by)
Scholarship@Western (Western University) (submittedVersion)
Funders: Canadian Institutes of Health Research
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
Life Sciences › Immunology and Microbiology › Microbiology › Reproductive tract infections research
Keywords: breast microbiome, breast cancer, bacterial diversity, adjacent normal tissue, tumor tissue, Bacillus, Enterobacteriaceae, Staphylococcus epidermidis, Escherichia coli, DNA double-strand breaks, H2AX phosphorylation, lactic acid bacteria, cancer risk, environmental factors
MeSH terms: Adult, Aged, Aged, 80 and over, Bacteria, Breast, Breast Neoplasms, Female, Humans, Middle Aged, Ontario, RNA, Ribosomal, 16S, Sequence Analysis, DNA, Young Adult, Microbiota

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The Microbiota of Breast Tissue and Its Association with Breast Cancer

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