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Conservation of the Chitin Utilization Pathway in the Vibrionaceae
Open accessAbstract
Vibrionaceae are regarded as important marine chitin degraders, and attachment to chitin regulates important biological functions; yet, the degree of chitin pathway conservation in Vibrionaceae is unknown. Here, a core chitin degradation pathway is proposed based on comparison of 19 Vibrio and Photobacterium genomes with a detailed metabolic map assembled for V. cholerae from published biochemical, genomic, and transcriptomic results. Further, to assess whether chitin degradation is a conserved property of Vibrionaceae, a set of 54 strains from 32 taxa were tested for the ability to grow on various forms of chitin. All strains grew on N-acetylglucosamine (GlcNAc), the monomer of chitin. The majority of isolates grew on alpha (crab shell) and beta (squid pen) chitin and contained chitinase A (chiA) genes. chiA sequencing and phylogenetic analysis suggest that this gene is a good indicator of chitin metabolism but appears subject to horizontal gene transfer and duplication. Overall, chitin metabolism appears to be a core function of Vibrionaceae, but individual pathway components exhibit dynamic evolutionary histories.
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“Vibrios are also known to express genes involved in the metabolic degradation of chitin (Hunt et al., 2008), an important component of the exoskeleton of the nauplii.”
From Potential lineage transmission within the active microbiota of the eggs and the nauplii of the shrimp Litopenaeus stylirostris : possible influence of the rearing water and more (2021) · cites this paper as Hunt et al., 2008
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Metadata
- Authors
- Hunt, D. E., Gevers, D., Vahora, N. M., & Polz, M. F.
- Affiliations
- Massachusetts Institute of Technology (US)
- Ghent University (BE)
- Corresponding author
- Polz, Martin F.
- Venue
- Applied and Environmental Microbiology
- Publisher
- American Society for Microbiology
- Published
- 2008-01
- Volume
- 74
- Issue
- 1
- Pages
- 44-51
- ISSN
- 0099-2240 (ISSN-L)
- 1098-5336
- PMC
- PMC2223224
- OpenAlex
- W2096419043
- Cited by
- 236
- References
- 46
- Citations by year
- 2026: 14 · 2025: 8 · 2024: 12 · 2023: 23 · 2022: 12 · 2021: 15 · 2020: 14 · 2019: 11 · 2018: 19 · 2017: 10 · 2016: 14 · 2015: 19 · 2014: 9 · 2013: 12 · 2012: 8
- FWCI
- 3.18
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Applied and Environmental Microbiology (publishedVersion)
- Flanders Marine Institute (Flanders Marine Institute) (publishedVersion, other-oa)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Ghent University Academic Bibliography (Ghent University) (submittedVersion, other-oa)
- Funders
- National Science Foundation
- U.S. Department of Energy (DEFG0208ER64516)
- Gordon and Betty Moore Foundation
- Vlaamse regering
- National Institute of Environmental Health Sciences
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Studies on Chitinases and Chitosanases
- Life Sciences › Immunology and Microbiology › Microbiology › Vibrio bacteria research studies
- Physical Sciences › Environmental Science › Ecology › Microbial Community Ecology and Physiology
- Keywords
- chitin degradation, Vibrionaceae, chitinase A, chiA gene, Vibrio, Photobacterium, horizontal gene transfer, gene duplication, marine bacteria
- MeSH terms
- Acetylglucosamine, Bacterial Proteins, Chitin, Chitinases, DNA, Bacterial, Molecular Sequence Data, Phylogeny, Vibrionaceae, Conserved Sequence, Sequence Analysis, DNA, Metabolic Networks and Pathways
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