The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Bacterial Persister Cell Formation and Dormancy
Open accessAbstract
Bacterial cells may escape the effects of antibiotics without undergoing genetic change; these cells are known as persisters. Unlike resistant cells that grow in the presence of antibiotics, persister cells do not grow in the presence of antibiotics. These persister cells are a small fraction of exponentially growing cells (due to carryover from the inoculum) but become a significant fraction in the stationary phase and in biofilms (up to 1%). Critically, persister cells may be a major cause of chronic infections. The mechanism of persister cell formation is not well understood, and even the metabolic state of these cells is debated. Here, we review studies relevant to the formation of persister cells and their metabolic state and conclude that the best model for persister cells is still dormancy, with the latest mechanistic studies shedding light on how cells reach this dormant state.
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Cites
Bacterial Persistence as a Phenotypic Switch
Balaban, N. Q., Merrin, J., Chait, R., Kowalik, L., & Leibler, S. (2004) · Science · doi:10.1126/science.1099390 · Cited by 2,952 · cited 3×
“Hence, work with HipA7, such as that showing persister cells arise stochastically (18), is not based on HipA7 acting as a toxin.”
BackgroundInfluentialPersister cells, dormancy and infectious disease
Lewis, K. (2007) · Nature Reviews Microbiology · doi:10.1038/nrmicro1557 · Cited by 2,052
Lewis, K. (2010) · Annual Review of Microbiology · doi:10.1146/annurev.micro.112408.134306 · Cited by 1,858
Metabolite-enabled eradication of bacterial persisters by aminoglycosides
Allison, K. R., Brynildsen, M. P., & Collins, J. J. (2011) · Nature · doi:10.1038/nature10069 · Cited by 1,025
Molecular Mechanisms of HipA-Mediated Multidrug Tolerance and Its Neutralization by HipB
Schumacher, M. A., Piro, K. M., Xu, W., Hansen, S., Lewis, K., & Brennan, R. G. (2009) · Science · doi:10.1126/science.1163806 · Cited by 351 · cited 2×
“The hipBA locus constitutes a toxin-antitoxin locus, and the HipA toxin inactivates the translation factor EF-Tu by phosphorylating it (other substrates may also exist) (17).”
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Cited by
Bacterial Biofilm Eradication Agents: A Current Review
Verderosa, A. D., Totsika, M., & Fairfull-Smith, K. E. (2019) · Frontiers in Chemistry · doi:10.3389/fchem.2019.00824 · Cited by 555
Intracellular Staphylococcus aureus persisters upon antibiotic exposure
Peyrusson, F., Varet, H., Nguyen, T. K., Legendre, R., Sismeiro, O., Coppée, J.-Y., Wolz, C., Tenson, T., & Van Bambeke, F. (2020) · Nature Communications · doi:10.1038/s41467-020-15966-7 · Cited by 392
Consensus guidelines for the identification and treatment of biofilms in chronic nonhealing wounds
Schultz, G., Bjarnsholt, T., James, G. A., Leaper, D. J., McBain, A. J., Malone, M., Stoodley, P., Swanson, T., Tachi, M., Wolcott, R. D., et al. (2017) · Wound Repair and Regeneration · doi:10.1111/wrr.12590 · Cited by 337
Elucidating cancer metabolic plasticity by coupling gene regulation with metabolic pathways
Jia, D., Lu, M., Jung, K. H., Park, J. H., Yu, L., Onuchic, J. N., Kaipparettu, B. A., & Levine, H. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1816391116 · Cited by 336
Pires, D., Melo, L., Vilas Boas, D., Sillankorva, S., & Azeredo, J. (2017) · Current Opinion in Microbiology · doi:10.1016/j.mib.2017.09.004 · Cited by 312
Metadata
- Authors
- Wood, T. K., Knabel, S. J., & Kwan, B. W.
- Venue
- Applied and Environmental Microbiology
- Publisher
- American Society for Microbiology
- Published
- 2013-12
- Volume
- 79
- Issue
- 23
- Pages
- 7116-7121
- ISSN
- 0099-2240 (ISSN-L)
- 1098-5336
- OpenAlex
- W2127817798
- Cited by
- 703
- References
- 5
- FWCI
- 14.77
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Wood, T. K., Knabel, S. J., & Kwan, B. W. (2013). Bacterial Persister Cell Formation and Dormancy. Applied and Environmental Microbiology. https://doi.org/10.1128/aem.02636-13
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
