The DOI matches its Crossref record; 56 of the 56 references it cites were found in a registry or an index.
Elucidating cancer metabolic plasticity by coupling gene regulation with metabolic pathways
Open accessAbstract
Significance: Metabolic plasticity allows cancer cells to adjust their metabolic phenotypes to adapt in hostile environments. There is an urgent need to understand the cross-talk between gene regulation and metabolic pathways underlying cancer metabolic plasticity. We establish a theoretical framework to decode the coupling of gene regulation and metabolic pathways. Our work characterizes a hybrid metabolic state where cells can use both glycolysis and oxidative phosphorylation (OXPHOS) and a possible metabolically inactive state where cells have low activity of both glycolysis and OXPHOS. We show that targeting both OXPHOS and glycolysis may be necessary to eliminate cancer aggressiveness. Our work serves as a platform to target abnormal metabolism in cancer by modulating both genes and metabolic pathways.
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Cites
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Cited by
Loh, C.-Y., Chai, J., Tang, T., Wong, W., Sethi, G., Shanmugam, M., Chong, P., & Looi, C. (2019) · Cells · doi:10.3390/cells8101118 · Cited by 1,315
The enhancement of glycolysis regulates pancreatic cancer metastasis
Yang, J., Ren, B., Yang, G., Wang, H., Chen, G., You, L., Zhang, T., & Zhao, Y. (2020) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-019-03278-z · Cited by 347
Metabolic reprogramming in triple-negative breast cancer
Wang, Z., Jiang, Q., & Dong, C. (2020) · Cancer Biology and Medicine · doi:10.20892/j.issn.2095-3941.2019.0210 · Cited by 248
“Indeed, they can also transit to an epithelial-like state to rely on OXPHOS 102 or stably maintain a hybrid metabolic phenotype with a high activity of both glycolysis and OXPHOS 110 .”
BackgroundThe role of glycolysis in tumorigenesis: From biological aspects to therapeutic opportunities
Cordani, M., Michetti, F., Zarrabi, A., Zarepour, A., Rumio, C., Strippoli, R., & Marcucci, F. (2024) · Neoplasia · doi:10.1016/j.neo.2024.101076 · Cited by 40
In situ metabolic Characterisation of Breast Cancer and its Potential Impact on Therapy
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Metadata
- Authors
- Jia, D., Lu, M., Jung, K. H., Park, J. H., Yu, L., Onuchic, J. N., Kaipparettu, B. A., & Levine, H.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2019-02-07
- Volume
- 116
- Issue
- 9
- Pages
- 3909-3918
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2911915561
- Cited by
- 336
- References
- 56
- FWCI
- 12.09
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Jia, D., Lu, M., Jung, K. H., Park, J. H., Yu, L., Onuchic, J. N., Kaipparettu, B. A., & Levine, H. (2019). Elucidating cancer metabolic plasticity by coupling gene regulation with metabolic pathways. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1816391116
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