The DOI matches its Crossref record.
Enhanced production of succinic acid by overexpression of phosphoenolpyruvate carboxylase in Escherichia coli
Open accessAbstract
Fermentative production of succinic acid from glucose by Escherichia coli was significantly increased by overexpression of phosphoenolpyruvate carboxylase. In contrast, overexpression of phosphoenolpyruvate carboxykinase had no effect. Under optimized conditions, induction of the carboxylase resulted in a 3.5-fold increase in the concentration of succinic acid, making succinic acid the major fermentation product by weight.
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Cited by
Davis, M. S., Solbiati, J., & Cronan, J. E. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m004756200 · Cited by 479
Inui, M., Murakami, S., Okino, S., Kawaguchi, H., Vertès, A. A., & Yukawa, H. (2004) · Microbial Physiology · doi:10.1159/000079827 · Cited by 326
The commercial production of chemicals using pathway engineering
Chotani, G., Dodge, T., Hsu, A., Kumar, M., LaDuca, R., Trimbur, D., Weyler, W., & Sanford, K. (2000) · Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology · doi:10.1016/s0167-4838(00)00234-x · Cited by 234
Metadata
- Authors
- Millard, C. S., Chao, Y. P., Liao, J. C., & Donnelly, M. I.
- Venue
- Applied and Environmental Microbiology
- Publisher
- American Society for Microbiology
- Published
- 1996-05
- Volume
- 62
- Issue
- 5
- Pages
- 1808-1810
- ISSN
- 0099-2240 (ISSN-L)
- 1098-5336
- OpenAlex
- W1793938508
- Cited by
- 231
- References
- 0
- FWCI
- 1.61
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Enhanced production of succinic acid by overexpression of phosphoenolpyruvate carboxylase in Escherichia coli. https://app.cochat.ai/papers/10.1128/aem.62.5.1808-1810.1996
- The paper
- Millard, C. S., Chao, Y. P., Liao, J. C., & Donnelly, M. I. (1996). Enhanced production of succinic acid by overexpression of phosphoenolpyruvate carboxylase in Escherichia coli. Applied and Environmental Microbiology. https://doi.org/10.1128/aem.62.5.1808-1810.1996
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
