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Production of the Carotenoids Lycopene, β-Carotene, and Astaxanthin in the Food Yeast Candida utilis
Open accessAbstract
The food-grade yeast Candida utilis has been engineered to confer a novel biosynthetic pathway for the production of carotenoids such as lycopene, β-carotene, and astaxanthin. The exogenous carotenoid biosynthesis genes were derived from the epiphytic bacterium Erwinia uredovora and the marine bacterium Agrobacterium aurantiacum . The carotenoid biosynthesis genes were individually modified based on the codon usage of the C. utilis glyceraldehyde 3-phosphate dehydrogenase gene and expressed in C. utilis under the control of the constitutive promoters and terminators derived from C. utilis . The resultant yeast strains accumulated lycopene, β-carotene, and astaxanthin in the cells at 1.1, 0.4, and 0.4 mg per g (dry weight) of cells, respectively. This was considered to be a result of the carbon flow into ergosterol biosynthesis being partially redirected to the nonendogenous pathway for carotenoid production.
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Citations
Cited by
Improving lycopene production in Escherichia coli by engineering metabolic control
Farmer, W. R., & Liao, J. C. (2000) · Nature Biotechnology · doi:10.1038/75398 · Cited by 522
Biotechnological production of carotenoids by yeasts: an overview
Mata-Gómez, L. C., Montañez, J. C., Méndez-Zavala, A., & Aguilar, C. N. (2014) · Microbial Cell Factories · doi:10.1186/1475-2859-13-12 · Cited by 508
Terpenoids: Opportunities for Biosynthesis of Natural Product Drugs Using Engineered Microorganisms
Ajikumar, P. K., Tyo, K., Carlsen, S., Mucha, O., Phon, T. H., & Stephanopoulos, G. (2008) · Molecular Pharmaceutics · doi:10.1021/mp700151b · Cited by 447
Secondary ketocarotenoid astaxanthin biosynthesis in algae: a multifunctional response to stress
Lemoine, Y., & Schoefs, B. (2010) · Photosynthesis Research · doi:10.1007/s11120-010-9583-3 · Cited by 384
Microbial Pigments in the Food Industry—Challenges and the Way Forward
Sen, T., Barrow, C. J., & Deshmukh, S. K. (2019) · Frontiers in Nutrition · doi:10.3389/fnut.2019.00007 · Cited by 367
Metadata
- Authors
- Miura, Y., Kondo, K., Saito, T., Shimada, H., Fraser, P. D., & Misawa, N.
- Venue
- Applied and Environmental Microbiology
- Publisher
- American Society for Microbiology
- Published
- 1998-04
- Volume
- 64
- Issue
- 4
- Pages
- 1226-1229
- ISSN
- 0099-2240 (ISSN-L)
- 1098-5336
- OpenAlex
- W2165034669
- Cited by
- 176
- References
- 0
- FWCI
- 1.35
- Type
- journal article
- Language
- en
- Open access
- green
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- Miura, Y., Kondo, K., Saito, T., Shimada, H., Fraser, P. D., & Misawa, N. (1998). Production of the Carotenoids Lycopene, β-Carotene, and Astaxanthin in the Food Yeast Candida utilis. Applied and Environmental Microbiology. https://doi.org/10.1128/aem.64.4.1226-1229.1998
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