Secondary ketocarotenoid astaxanthin biosynthesis in algae: a multifunctional response to stress
Open accessAbstract
Under stressful environments, many green algae such as Haematococcus pluvialis accumulate secondary ketocarotenoids such as canthaxanthin and astaxanthin. The carotenogenesis, responsible for natural phenomena such as red snows, generally accompanies larger metabolic changes as well as morphological modifications, i.e., the conversion of the green flagellated macrozoids into large red cysts. Astaxanthin accumulation constitutes a convenient way to store energy and carbon, which will be used for further synthesis under less stressful conditions. Besides this, the presence of high amount of astaxanthin enhances the cell resistance to oxidative stress generated by unfavorable environmental conditions including excess light, UV-B irradiation, and nutrition stress and, therefore, confers a higher survival capacity to the cells. This better resistance results from the quenching of oxygen atoms for the synthesis itself as well as from the antioxidant properties of the astaxanthin molecules. Therefore, astaxanthin synthesis corresponds to a multifunctional response to stress. In this contribution, the various biochemical, genetic, and molecular data related to the biosynthesis of ketocarotenoids by Haematococcus pluvialis and other taxa are reviewed and compared. A tentative regulatory model of the biochemical network driving astaxanthin production is proposed.
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Haematococcus pluvialis synthesizes astaxanthin in response to environmental stress.
“This microalga synthesizes astaxanthin in response to environmental stress [153].”
From The promising future of microalgae: Current status, challenges, and optimization of a sustainable and renewable industry for biofuels, feed, and other products (2018) · cites this paper as [153]
Cites
Reactive oxygen species: Metabolism, oxidative stress, and signal transduction
Apel, K., & Hirt, H. (2004) · Annual Review of Plant Biology · doi:10.1146/annurev.arplant.55.031903.141701 · Cited by 11,723 · see citing works
Oxidative stress, antioxidants and stress tolerance
Mittler, R. (2002) · Trends in Plant Science · doi:10.1016/s1360-1385(02)02312-9 · Cited by 10,790 · see citing works
Asada, K. (1999) · Annual Review of Plant Physiology and Plant Molecular Biology · doi:10.1146/annurev.arplant.50.1.601 · Cited by 4,038 · see citing works
Antioxidants, Oxidative Damage and Oxygen Deprivation Stress: a Review
Blokhina, O. B. (2002) · Annals of Botany · doi:10.1093/aob/mcf118 · Cited by 4,018 · see citing works
Microalgal triacylglycerols as feedstocks for biofuel production: perspectives and advances
Hu, Q., Sommerfeld, M., Jarvis, E., Ghirardi, M., Posewitz, M., Seibert, M., & Darzins, A. (2008) · The Plant Journal · doi:10.1111/j.1365-313x.2008.03492.x · Cited by 3,745 · see citing works
Zhu, J. (2001) · Trends in Plant Science · doi:10.1016/s1360-1385(00)01838-0 · Cited by 3,595 · see citing works
Mitochondrial reactive oxygen species trigger hypoxia-induced transcription
Chandel, N. S., Maltepe, E., Goldwasser, E., Mathieu, C. E., Simon, M. C., & Schumacker, P. T. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.20.11715 · Cited by 1,926 · see citing works
Møller, I. M. (2001) · Annual Review of Plant Physiology and Plant Molecular Biology · doi:10.1146/annurev.arplant.52.1.561 · Cited by 1,662 · see citing works
Haematococcus astaxanthin: applications for human health and nutrition
Guerin, M., Huntley, M. E., & Olaizola, M. (2003) · Trends in Biotechnology · doi:10.1016/s0167-7799(03)00078-7 · Cited by 1,495 · see citing works
THE 1-DEOXY-D-XYLULOSE-5-PHOSPHATE PATHWAY OF ISOPRENOID BIOSYNTHESIS IN PLANTS
Lichtenthaler, H. K. (1999) · Annual Review of Plant Physiology and Plant Molecular Biology · doi:10.1146/annurev.arplant.50.1.47 · Cited by 1,403 · see citing works
The biosynthesis and nutritional uses of carotenoids
Fraser, P. D. (2003) · Progress in Lipid Research · doi:10.1016/j.plipres.2003.10.002 · Cited by 1,382 · see citing works
Handbook of Plant and Crop Stress
Pessarakli, M. (1999) · CRC Press eBooks · doi:10.1201/9780824746728 · Cited by 1,327 · see citing works
Astaxanthin: a review of its chemistry and applications
Higuera-Ciapara, I., Félix-Valenzuela, L., & Goycoolea, F. M. (2006) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408690590957188 · Cited by 1,287 · see citing works
Commercial potential for Haematococcus microalgae as a natural source of astaxanthin
Lorenz, R. T., & Cysewski, G. R. (2000) · Trends in biotechnology · doi:10.1016/s0167-7799(00)01433-5 · Cited by 1,190 · see citing works
Role of the Arabidopsis Glucose Sensor HXK1 in Nutrient, Light, and Hormonal Signaling
Moore, B. D., Zhou, L., Rolland, F., Hall, Q., Cheng, W., Liu, Y., Hwang, I., Jones, T., & Sheen, J. (2003) · Science · doi:10.1126/science.1080585 · Cited by 1,184 · see citing works
Sugar Sensing and Signaling in Plants
Rolland, F., Moore, B. D., & Sheen, J. (2002) · The Plant Cell · doi:10.1105/tpc.010455 · Cited by 1,177 · see citing works
Causes of Photooxidative Stress and Amelioration of Defense Systems in Plants
Foyer, C. H., & Mullineaux, P. M. (2019) · CRC Press eBooks · doi:10.1201/9781351070454 · Cited by 971 · see citing works
GENES AND ENZYMES OF CAROTENOID BIOSYNTHESIS IN PLANTS
Cunningham, F. X., & Gantt, E. (1998) · Annual Review of Plant Physiology and Plant Molecular Biology · doi:10.1146/annurev.arplant.49.1.557 · Cited by 966 · see citing works
Cytochromes P450: a success story.
Werck‐Reichhart, D., & Feyereisen, R. (2000) · Genome biology · doi:10.1186/gb-2000-1-6-reviews3003 · Cited by 962 · see citing works
Mechanism of Inhibition of Protein-tyrosine Phosphatases by Vanadate and Pervanadate
Huyer, G., Liu, S., Kelly, J., Moffat, J., Payette, P., Kennedy, B. P., Tsaprailis, G., Gresser, M. J., & Ramachandran, C. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.2.843 · Cited by 815 · see citing works
ALTERNATIVE OXIDASE: From Gene to Function
Vanlerberghe, G. C., & McIntosh, L. (1997) · Annual Review of Plant Physiology and Plant Molecular Biology · doi:10.1146/annurev.arplant.48.1.703 · Cited by 796 · see citing works
Rapid Stimulation of an Oxidative Burst during Elicitation of Cultured Plant Cells
Apostoł, I., Heinstein, P. F., & Low, P. S. (1989) · PLANT PHYSIOLOGY · doi:10.1104/pp.90.1.109 · Cited by 684 · see citing works
Sugar sensing in higher plants.
Jang, J.-C., & Sheen, J. (1994) · The Plant Cell · doi:10.1105/tpc.6.11.1665 · Cited by 679 · see citing works
Safety valves for photosynthesis
Niyogi, K. (2000) · Current Opinion in Plant Biology · doi:10.1016/s1369-5266(00)00113-8 · Cited by 663 · see citing works
Escoubas, J.-M., Lomas, M. W., LaRoche, J., & Falkowski, P. G. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.22.10237 · Cited by 662 · see citing works
Stress Responses in Plants: Adaptation and Acclimation Mechanisms
Alscher, R., & Cumming, J. (1990) · Medical Entomology and Zoology · Cited by 617 · see citing works
Photosynthetic control of chloroplast gene expression
Pfannschmidt, T., Nilsson, A., & Allen, J. F. (1999) · Nature · doi:10.1038/17624 · Cited by 617 · see citing works
Carotenogenesis in the green alga Haematococcus pluvialis : Cellular physiology and stress response
Boussiba, S. (2000) · Physiologia Plantarum · doi:10.1034/j.1399-3054.2000.108002111.x · Cited by 591 · see citing works
Production and Action of Active Oxygen Species in Photosynthetic Tissues
Asada, K. (2019) · CRC Press eBooks · doi:10.1201/9781351070454-3 · Cited by 588 · see citing works
Carlson, M. (1999) · Current Opinion in Microbiology · doi:10.1016/s1369-5274(99)80035-6 · Cited by 578 · see citing works
Astaxanthin from Microbial Sources
Johnson, E. A., & An, G.-H. (1991) · Critical Reviews in Biotechnology · doi:10.3109/07388559109040622 · Cited by 509 · see citing works
Comprehensive Natural Products II
(2010) · Elsevier eBooks · doi:10.1016/c2009-1-28362-6 · Cited by 464 · see citing works
Misawa, N., Satomi, Y., Kondô, K., Yokoyama, A., Kajiwara, S., Saito, T., Ohtani, T., & Miki, W. (1995) · Journal of Bacteriology · doi:10.1128/jb.177.22.6575-6584.1995 · Cited by 456 · see citing works
Antioxidant activity of β‐carotene‐related carotenoids in solution
Terao, J. (1989) · Lipids · doi:10.1007/bf02535085 · Cited by 434 · see citing works
Perspectives on Oxygen Sensing
Semenza, G. L. (1999) · Cell · doi:10.1016/s0092-8674(00)81957-1 · Cited by 385 · see citing works
Ben‐Amotz, A., & Avron, M. (1983) · PLANT PHYSIOLOGY · doi:10.1104/pp.72.3.593 · Cited by 365 · see citing works
Kobayashi, M., Kakizono, T., & Nagai, S. (1993) · Applied and Environmental Microbiology · doi:10.1128/aem.59.3.867-873.1993 · Cited by 360 · see citing works
Olaizola, M. (2000) · Journal of Applied Phycology · doi:10.1023/a:1008159127672 · Cited by 359 · see citing works
Astaxanthin and canthaxanthin are potent antioxidants in a membrane model
Palozza, P., & Krinsky, N. I. (1992) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(92)90675-m · Cited by 346 · see citing works
Carol, P., Stevenson, D., Bisanz, C., Breitenbach, J., Sandmann, G., Mache, R., Coupland, G., & Kuntz, M. (1999) · The Plant Cell · doi:10.1105/tpc.11.1.57 · Cited by 340 · see citing works
Staehelin, L. A., & Arntzen, C. J. (1983) · The Journal of Cell Biology · doi:10.1083/jcb.97.5.1327 · Cited by 333 · see citing works
Del Campo, J. (2000) · Journal of Biotechnology · doi:10.1016/s0168-1656(99)00178-9 · Cited by 323 · see citing works
Glucose-sensing mechanisms in eukaryotic cells
Rolland, F., Winderickx, J., & Thevelein, J. M. (2001) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(01)01805-9 · Cited by 313 · see citing works
Chamovitz, D., Sandmann, G., & Hirschberg, J. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)85341-3 · Cited by 299 · see citing works
Wu, D., Wright, D. A., Wetzel, C. M., Voytas, D. F., & Rodermel, S. R. (1999) · The Plant Cell · doi:10.1105/tpc.11.1.43 · Cited by 291 · see citing works
Carotenoid biosynthesis in microorganisms and plants
Sandmann, G. (1994) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1994.tb18961.x · Cited by 287 · see citing works
Allen, J. F. (1993) · Journal of Theoretical Biology · doi:10.1006/jtbi.1993.1210 · Cited by 279 · see citing works
Production of astaxanthin by the green microalga Chlorella zofingiensis in the dark
Ip, P.-F., & Chen, F. (2005) · Process Biochemistry · doi:10.1016/j.procbio.2004.01.039 · Cited by 270 · see citing works
Zhekisheva, M., Boussiba, S., Khozin‐Goldberg, I., Zarka, A., & Cohen, Z. (2002) · Journal of Phycology · doi:10.1046/j.1529-8817.2002.01107.x · Cited by 267 · see citing works
Rabbani, S., Beyer, P., Lintig, J. V., Hugueney, P., & Kleinig, H. (1998) · PLANT PHYSIOLOGY · doi:10.1104/pp.116.4.1239 · Cited by 263 · see citing works
Photosynthesis, pigments and ultrastructure of the alpine snow alga Chlamydomonas nivalis
Remias, D., Lütz‐Meindl, U., & Lütz, C. (2005) · European Journal of Phycology · doi:10.1080/09670260500202148 · Cited by 259 · see citing works
Maxwell, D. P., Nickels, R. L., & McIntosh, L. (2002) · The Plant Journal · doi:10.1046/j.1365-313x.2002.01216.x · Cited by 249 · see citing works
Boussiba, S., Bing, W., Yuan, J.-P., Zarka, A., & Chen, F. (1999) · Biotechnology Letters · doi:10.1023/a:1005507514694 · Cited by 247 · see citing works
EVIDENCE A PHOTOPROTECTIVE FOR SECONDARY CAROTENOIDS OF SNOW ALGAE1
Bidigare, R. R., Ondrusek, M. E., Kennicutt, M. C., Iturriaga, R. H., Harvey, H. R., Hoham, R. W., & Macko, S. A. (1993) · Journal of Phycology · doi:10.1111/j.1529-8817.1993.tb00143.x · Cited by 244 · see citing works
Metabolic engineering of astaxanthin production in tobacco flowers
Mann, V., Harker, M., Pecker, I., & Hirschberg, J. (2000) · Nature Biotechnology · doi:10.1038/78515 · Cited by 239 · see citing works
Steinbrenner, J., & Sandmann, G. (2006) · Applied and Environmental Microbiology · doi:10.1128/aem.01461-06 · Cited by 226 · see citing works
Singlet oxygen quenching ability of astaxanthin esters from the green alga Haematococcus pluvialis
Kobayashi, M., & Sakamoto, Y. (1999) · Biotechnology Letters · doi:10.1023/a:1005445927433 · Cited by 223 · see citing works
Steinbrenner, J., & Linden, H. (2001) · PLANT PHYSIOLOGY · doi:10.1104/pp.125.2.810 · Cited by 221 · see citing works
Ben‐Amotz, A., Shaish, A., & Avron, M. (1989) · PLANT PHYSIOLOGY · doi:10.1104/pp.91.3.1040 · Cited by 212 · see citing works
Kajiwara, S., Fraser, P. D., Kondô, K., & Misawa, N. (1997) · Biochemical Journal · doi:10.1042/bj3240421 · Cited by 210 · see citing works
Singlet Oxygen and Peroxyl Radicals Regulate Carotenoid Biosynthesis in Phaffia rhodozyma
Schroeder, W. A., & Johnson, E. A. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.31.18374 · Cited by 209 · see citing works
Steinbrenner, J., & Linden, H. (2003) · Plant Molecular Biology · doi:10.1023/a:1023948929665 · Cited by 203 · see citing works
Josse, E., Simkin, A. J., Gaffé, J., Labouré, A., Kuntz, M., & Carol, P. (2000) · PLANT PHYSIOLOGY · doi:10.1104/pp.123.4.1427 · Cited by 202 · see citing works
In Vitro Characterization of Astaxanthin Biosynthetic Enzymes
Fraser, P. D., Miura, Y., & Misawa, N. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.10.6128 · Cited by 197 · see citing works
Tanaka, T., Morishita, Y., Suzui, M., Kojima, T., Okumura, A., & Mori, H. (1994) · Carcinogenesis · doi:10.1093/carcin/15.1.15 · Cited by 196 · see citing works
Sun, N., Wang, Y., Li, Y., Huang, J., & Chen, F. (2008) · Process Biochemistry · doi:10.1016/j.procbio.2008.07.014 · Cited by 194 · see citing works
Wang, B., Zarka, A., Trebst, A., & Boussiba, S. (2003) · Journal of Phycology · doi:10.1111/j.0022-3646.2003.03-043.x · Cited by 188 · see citing works
Antioxidant role of astaxanthin in the green alga Haematococcus pluvialis
Kobayashi, M., Kakizono, T., Nishio, N., Nagai, S., Kurimura, Y., & Tsuji, Y. (1997) · Applied Microbiology and Biotechnology · doi:10.1007/s002530051061 · Cited by 185 · see citing works
Ip, P.-F., Wong, K.-H., & Chen, F. (2004) · Process Biochemistry · doi:10.1016/j.procbio.2003.08.003 · Cited by 184 · see citing works
Abe, K., Hattori, H., & Hirano, M. (2007) · Food Chemistry · doi:10.1016/j.foodchem.2005.10.026 · Cited by 182 · see citing works
Pessarakli, M. (ed.): Handbook of plant and crop stress
Pospišilová, J. (1994) · Biologia Plantarum · doi:10.1007/bf02921182 · Cited by 180 · see citing works
Shimada, H., Kondô, K., Fraser, P. D., Miura, Y., Saito, T., & Misawa, N. (1998) · Applied and Environmental Microbiology · doi:10.1128/aem.64.7.2676-2680.1998 · Cited by 178 · see citing works
Lotan, T., & Hirschberg, J. (1995) · FEBS Letters · doi:10.1016/0014-5793(95)00368-j · Cited by 176 · see citing works
Production of the Carotenoids Lycopene, β-Carotene, and Astaxanthin in the Food Yeast Candida utilis
Miura, Y., Kondô, K., Saito, T., Shimada, H., Fraser, P. D., & Misawa, N. (1998) · Applied and Environmental Microbiology · doi:10.1128/aem.64.4.1226-1229.1998 · Cited by 176 · see citing works
Grünewald, K., Hirschberg, J., & Hagen, C. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m006400200 · Cited by 175 · see citing works
Astaxanthin, Oxidative stress, Inflammation and Cardiovascular Disease
Fassett, R. G., & Coombes, J. S. (2009) · Future Cardiology · doi:10.2217/fca.09.19 · Cited by 170 · see citing works
Biosynthesis of astaxanthin in tobacco leaves by transplastomic engineering
Hasunuma, T., Miyazawa, S., Yoshimura, S., Shinzaki, Y., Tomizawa, K., Shindo, K., Choi, S. K., Misawa, N., & Miyake, C. (2008) · The Plant Journal · doi:10.1111/j.1365-313x.2008.03559.x · Cited by 168 · see citing works
Production of ketocarotenoids by microalgae
Margalith, P. (1999) · Applied Microbiology and Biotechnology · doi:10.1007/s002530051413 · Cited by 165 · see citing works
Vidhyavathi, R., Venkatachalam, L., Sarada, R., & Ravishankar, G. A. (2008) · Journal of Experimental Botany · doi:10.1093/jxb/ern048 · Cited by 164 · see citing works
[36] Enhancement and determination of astaxanthin accumulation in green alga Haematococcus pluvialis
Boussiba, S., Fan, L., & Vonshak, A. (1992) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(92)13140-s · Cited by 163 · see citing works
Kajiwara, S., Kakizono, T., Saito, T., Kondô, K., Ohtani, T., Nishio, N., Nagai, S., & Misawa, N. (1995) · Plant Molecular Biology · doi:10.1007/bf00043657 · Cited by 163 · see citing works
Production and analysis of secondary carotenoids in green algae
García, M. O., Torres, E., Fidalgo, P., & Abalde, J. (2000) · Journal of Applied Phycology · doi:10.1023/a:1008173807143 · Cited by 159 · see citing works
Li, Y., Sommerfeld, M. R., Chen, F., & Hu, Q. (2008) · Journal of Plant Physiology · doi:10.1016/j.jplph.2007.12.007 · Cited by 159 · see citing works
The hexose carrier from Chlorella
Sauer, N., & Tanner, W. (1989) · FEBS Letters · doi:10.1016/0014-5793(89)81489-9 · Cited by 156 · see citing works
Signaling pathways from the chloroplast to the nucleus
Beck, C. F. (2005) · Planta · doi:10.1007/s00425-005-0021-2 · Cited by 156 · see citing works
Miao, F., Lu, D., Li, Y., & Zeng, M. (2006) · Analytical Biochemistry · doi:10.1016/j.ab.2006.03.006 · Cited by 154 · see citing works
Sun, Z., Cunningham, F. X., & Gantt, E. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.19.11482 · Cited by 153 · see citing works
Grung, M., D'Souza, F. M. L., Borowitzka, M., & Liaaen-Jensen, S. (1992) · Journal of Applied Phycology · doi:10.1007/bf02442465 · Cited by 151 · see citing works
Hyper-accumulation of astaxanthin in a green algaHaematococcus pluvialis at elevated temperatures
Tjahjono, A. E., Hayama, Y., Kakizono, T., Terada, Y., Nishio, N., & Nagai, S. (1994) · Biotechnology Letters · doi:10.1007/bf01021659 · Cited by 151 · see citing works
Snow algae from northwest Svalbard: their identification, distribution, pigment and nutrient content
Müller, T., Bleiß, W., Martin, C.-D., Rogaschewski, S., & Fuhr, G. (1998) · Polar Biology · doi:10.1007/s003000050272 · Cited by 149 · see citing works
Astaxanthin-Rich Algal Meal and Vitamin C Inhibit Helicobacter pylori Infection in BALB/cA Mice
Wang, X., Wïllén, R., & Wadström, T. (2000) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.44.9.2452-2457.2000 · Cited by 149 · see citing works
Kobayashi, M., Kakizono, T., Nishio, N., & Nagai, S. (1992) · Journal of Fermentation and Bioengineering · doi:10.1016/0922-338x(92)90271-u · Cited by 148 · see citing works
Metabolic engineering of novel ketocarotenoid production in carrot plants
Jayaraj, J., Devlin, R. H., & Punja, Z. K. (2007) · Transgenic Research · doi:10.1007/s11248-007-9120-0 · Cited by 146 · see citing works
García, M. O., Valero, J. F., Herrero, C., & Abalde, J. (2001) · Biotechnology Letters · doi:10.1023/a:1010510508384 · Cited by 143 · see citing works
Bleaching Herbicide Norflurazon Inhibits Phytoene Desaturase by Competition with the Cofactors
Breitenbach, J., Zhu, C., & Sandmann, G. (2001) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf0106751 · Cited by 142 · see citing works
The Hexose‐Proton Symport System of Chlorella vulgaris
Komor, E., & Tanner, W. (1974) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1974.tb03476.x · Cited by 136 · see citing works
Leya, T., Rahn, A., Lütz, C., & Remias, D. (2009) · FEMS Microbiology Ecology · doi:10.1111/j.1574-6941.2008.00641.x · Cited by 135 · see citing works
Coesel, S., Baumgartner, A., Teles, L. M., Ramos, A., Henriques, N., Cancela, M. L., & Varela, J. C. S. (2008) · Marine Biotechnology · doi:10.1007/s10126-008-9100-2 · Cited by 134 · see citing works
Cerón, M. C., García‐Malea, M. C., Rivas, J., Acién, F. G., Fernández-Sevilla, J. M., Río, E. D., Guerrero, M. G., & Molina, E. (2006) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-006-0743-5 · Cited by 134 · see citing works
Pigment and Structural Changes in Chlorella zofingiensis upon Light and Nitrogen Stress
Bar, E., Rise, M., Vishkautsan, M., & Arad, S. M. (1995) · Journal of Plant Physiology · doi:10.1016/s0176-1617(11)82019-5 · Cited by 127 · see citing works
Zhekisheva, M., Zarka, A., Khozin‐Goldberg, I., Cohen, Z., & Boussiba, S. (2005) · Journal of Phycology · doi:10.1111/j.0022-3646.2005.05015.x · Cited by 127 · see citing works
Shanmugam, K., Chandrashekar, A., Ravishankar, G. A., & Sarada, R. (2009) · Journal of Phycology · doi:10.1111/j.1529-8817.2009.00688.x · Cited by 126 · see citing works
Wang, S.-B., Chen, F., Sommerfeld, M. R., & Hu, Q. (2004) · Planta · doi:10.1007/s00425-004-1323-5 · Cited by 126 · see citing works
A study in scarlet: enzymes of ketocarotenoid biosynthesis in the flowers of Adonis aestivalis
Cunningham, F. X., & Gantt, E. (2005) · The Plant Journal · doi:10.1111/j.1365-313x.2004.02309.x · Cited by 125 · see citing works
Young, A. J., & Britton, G. (1990) · Cited by 124 · see citing works
Remias, D., Karsten, U., Lütz, C., & Leya, T. (2010) · PROTOPLASMA · doi:10.1007/s00709-010-0123-y · Cited by 123 · see citing works
Pelah, D., Sintov, A., & Cohen, E. (2004) · World Journal of Microbiology and Biotechnology · doi:10.1023/b:wibi.0000040398.93103.21 · Cited by 123 · see citing works
Grünewald, K., Eckert, M., Hirschberg, J., & Hagen, C. (2000) · PLANT PHYSIOLOGY · doi:10.1104/pp.122.4.1261 · Cited by 119 · see citing works
Ip, P.-F., & Chen, F. (2005) · Process Biochemistry · doi:10.1016/j.procbio.2005.02.014 · Cited by 117 · see citing works
Morphological changes in the life cycle of the green alga Haematococcus pluvialis
Kobayashi, M., Kurimura, Y., Kakizono, T., Nishio, N., & Tsuji, Y. (1997) · Journal of Fermentation and Bioengineering · doi:10.1016/s0922-338x(97)82794-8 · Cited by 116 · see citing works
Li, Y., Sommerfeld, M. R., Chen, F., & Hu, Q. (2009) · Journal of Applied Phycology · doi:10.1007/s10811-009-9453-6 · Cited by 116 · see citing works
Strategies of ultraviolet-B protection in microscopic algae
Xiong, F. S., Komenda, J., Kopecký, J., & Nedbal, L. (1997) · Physiologia Plantarum · doi:10.1111/j.1399-3054.1997.tb04796.x · Cited by 116 · see citing works
Río, E. D., Acién, F. G., García‐Malea, M. C., Rivas, J., Grima, E. M., & Guerrero, M. G. (2005) · Biotechnology and Bioengineering · doi:10.1002/bit.20547 · Cited by 116 · see citing works
Huang, J., Chen, F., & Sandmann, G. (2005) · Journal of Biotechnology · doi:10.1016/j.jbiotec.2005.09.002 · Cited by 111 · see citing works
Tracey, A., & Gresser, M. J. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.3.609 · Cited by 111 · see citing works
Engineering ketocarotenoid biosynthesis in potato tubers
Morris, W. L., Ducreux, L. J. M., Fraser, P. D., Millam, S., & Taylor, M. A. (2006) · Metabolic Engineering · doi:10.1016/j.ymben.2006.01.001 · Cited by 110 · see citing works
Light-driven active uptake of 3-O-methylglucose via an inducible hexose uptake system of Chlorella
Tanner, W. (1969) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(69)90326-x · Cited by 110 · see citing works
Lers, A., Levy, H., & Zamir, A. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)92755-9 · Cited by 107 · see citing works
Martin, J. F., Gudiña, E. J., & Barredo, J. L. (2008) · Microbial Cell Factories · doi:10.1186/1475-2859-7-3 · Cited by 105 · see citing works
EFFECT OF TEMPERATURE AND IRRADIANCE ON GROWTH OF HAEMATOCOCCUS PLUVIALIS (CHLOROPHYCEAE)1
Fan, L., Vonshak, A., & Boussiba, S. (1994) · Journal of Phycology · doi:10.1111/j.0022-3646.1994.00829.x · Cited by 104 · see citing works
Lu, Y., Jiang, P., Liu, S., Gan, Q., Cui, H., & Qin, S. (2010) · Bioresource Technology · doi:10.1016/j.biortech.2010.03.072 · Cited by 103 · see citing works
Susek, R. E., & Chory, J. (1992) · Australian Journal of Plant Physiology · doi:10.1071/pp9920387 · Cited by 103 · see citing works
Linden, H. (1999) · Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression · doi:10.1016/s0167-4781(99)00088-3 · Cited by 102 · see citing works
Optical purity of (3S,3'S)-astaxanthin from Haematococcus pluvialis
Renstrøm, B., Borch, G., Skulberg, O. M., & Jensen, S. L. (1981) · Phytochemistry · doi:10.1016/0031-9422(81)83094-4 · Cited by 102 · see citing works
Yong, Y. Y. R., & Lee, Y.-K. (1991) · Phycologia · doi:10.2216/i0031-8884-30-3-257.1 · Cited by 101 · see citing works
Schoefs, B., Rmiki, N.-E., Rachadi, J., & Lemoine, Y. (2001) · FEBS Letters · doi:10.1016/s0014-5793(01)02596-0 · Cited by 100 · see citing works
Self-citationOxidant-Induced Signaling: Effects of Peroxynitrite and Singlet Oxygen
Klotz, L. (2002) · Biological Chemistry · doi:10.1515/bc.2002.047 · Cited by 99 · see citing works
Kakizono, T., Kobayashi, M., & Nagai, S. (1992) · Journal of Fermentation and Bioengineering · doi:10.1016/0922-338x(92)90041-r · Cited by 98 · see citing works
Levy, H., Tal, T., Shaish, A., & Zamir, A. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)36870-x · Cited by 97 · see citing works
Metabolic engineering of ketocarotenoid biosynthesis in higher plants
Zhu, C., Naqvi, S., Capell, T., & Christou, P. (2008) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2008.10.029 · Cited by 96 · see citing works
Fraser, P. D., Shimada, H., & Misawa, N. (1998) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.1998.2520229.x · Cited by 95 · see citing works
Accumulation of Secondary Carotenoids in Chlorella zofingiensis
Rise, M., Cohen, E., Vishkautsan, M., Cojocaru, M., Gottlieb, H. E., & Arad, S. M. (1994) · Journal of Plant Physiology · doi:10.1016/s0176-1617(11)81189-2 · Cited by 92 · see citing works
Jyonouchi, H., Sun, S., Tomita, Y., & Gross, M. D. (1995) · Journal of Nutrition · doi:10.1093/jn/125.10.2483 · Cited by 90 · see citing works
İmamoğlu, E., Dalay, M. C., & Sukan, F. V. (2009) · New Biotechnology · doi:10.1016/j.nbt.2009.08.007 · Cited by 89 · see citing works
Progress in understanding the origin and functions of carotenoid hydroxylases in plants
Tian, L., & DellaPenna, D. (2004) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2004.02.003 · Cited by 88 · see citing works
Does Astaxanthin Protect Haematococcus against Light Damage?
Fan, L., Vonshak, A., Zarka, A., & Boussiba, S. (1998) · Zeitschrift für Naturforschung C · doi:10.1515/znc-1998-1-217 · Cited by 88 · see citing works
Jasmonic acid affects changes in the growth and some components content in alga Chlorella vulgaris
Czerpak, R., Piotrowska, A., & Szulecka, K. (2006) · Acta Physiologiae Plantarum · doi:10.1007/bf02706531 · Cited by 87 · see citing works
Harker, M., & Hirschberg, J. (1997) · FEBS Letters · doi:10.1016/s0014-5793(97)00110-5 · Cited by 84 · see citing works
Carotenogenesis in Haematococcus pluvialis
Droop, M. R. (1955) · Nature · doi:10.1038/175042a0 · Cited by 84 · see citing works
Li, Y., Huang, J., Sandmann, G., & Chen, F. (2009) · Journal of Phycology · doi:10.1111/j.1529-8817.2009.00689.x · Cited by 83 · see citing works
Primary and secondary carotenoids in two races of the green alga Botryococcus braunii
Grung, M., Metzger, P., & Liaaen‐Jensen, S. (1989) · Biochemical Systematics and Ecology · doi:10.1016/0305-1978(89)90001-x · Cited by 81 · see citing works
Jin, E., & Lee, C. (2006) · Journal of Microbiology and Biotechnology · Cited by 81 · see citing works
The accumulation and metabolism of astaxanthin in Scenedesmus obliquus (Chlorophyceae)
Qin, S., Liu, G., & Hu, Z. (2008) · Process Biochemistry · doi:10.1016/j.procbio.2008.03.010 · Cited by 80 · see citing works
Santos, M. F., & Mesquita, J. F. (1984) · CYTOLOGIA · doi:10.1508/cytologia.49.215 · Cited by 80 · see citing works
Carotenoids. Volume 4: natural functions.
Britton, G., Jensen, S. L., & PFANDER, H. (2008) · Digital Access to Libraries (Université catholique de Louvain (UCL), l'Université de Namur (UNamur) and the Université Saint-Louis (USL-B)) · doi:10.1007/978-3-7643-7499-0 · Cited by 80 · see citing works
Kobayashi, M. (2003) · Biotechnology and Bioprocess Engineering · doi:10.1007/bf02949275 · Cited by 79 · see citing works
Hu, Z., Li, Y., Sommerfeld, M. R., Chen, F., & Hu, Q. (2008) · European Journal of Phycology · doi:10.1080/09670260802227736 · Cited by 79 · see citing works
Huang, J., Wang, Y., Sandmann, G., & Chen, F. (2005) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-005-0166-8 · Cited by 77 · see citing works
Secondary carotenoids formation by the green alga Chlorococcum sp.
Liu, B., & Lee, Y. K. (2000) · Journal of Applied Phycology · doi:10.1023/a:1008185212724 · Cited by 76 · see citing works
Remias, D., Holzinger, A., & Lütz, C. (2009) · Phycologia · doi:10.2216/08-13.1 · Cited by 76 · see citing works
Wang, J., Sommerfeld, M. R., & Hu, Q. (2009) · Planta · doi:10.1007/s00425-009-0932-4 · Cited by 75 · see citing works
Plant cell compartments: selected topics.
Schoefs, B. (2008) · Cited by 74 · see citing works
Self-citationSynthesis of ketocarotenoids in the seed of Arabidopsis thaliana
Stålberg, K., Lindgren, O., Ek, B., & Höglund, A. (2003) · The Plant Journal · doi:10.1046/j.1365-313x.2003.01919.x · Cited by 73 · see citing works
Yin-Nin, R., & Chen, F. (2001) · Process Biochemistry · doi:10.1016/s0032-9592(01)00157-1 · Cited by 73 · see citing works
Hagen, C., Braune, W., & Greulich, F. (1993) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/1011-1344(93)80145-y · Cited by 69 · see citing works
Li, Y., Huang, J., Sandmann, G., & Chen, F. (2008) · Planta · doi:10.1007/s00425-008-0775-4 · Cited by 66 · see citing works
Astaxanthin Production by Haematococcus pluvialis under Various Light Intensities and Wavelengths
Park, E., & Lee, C. (2001) · Journal of Microbiology and Biotechnology · Cited by 65 · see citing works
Stadler, R., Wolf, K., Hilgarth, C., Tanner, W., & Sauer, N. (1995) · PLANT PHYSIOLOGY · doi:10.1104/pp.107.1.33 · Cited by 63 · see citing works
Expression in Escherichia coli and properties of the carotene ketolase from Haematococcus pluvialis
Breitenbach, J. (1996) · FEMS Microbiology Letters · doi:10.1016/0378-1097(96)00187-5 · Cited by 63 · see citing works
Řezanka, T., Nedbalová, L., Sigler, K., & Cepák, V. (2007) · Phytochemistry · doi:10.1016/j.phytochem.2007.06.025 · Cited by 62 · see citing works
Hagen, C., Grünewald, K., Schmidt, S., & MÜLLER, J. (2000) · European Journal of Phycology · doi:10.1080/09670260010001735651 · Cited by 62 · see citing works
Expression in Escherichia coli and properties of the carotene ketolase from Haematococcus pluvialis
Breitenbach, J. ⁄. R., Misawa, N., Kajiwara, S., et al. (1996) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.1996.tb08343.x · Cited by 60 · see citing works
Pathway engineering of plants toward astaxanthin production
Misawa, N. (2009) · Plant Biotechnology · doi:10.5511/plantbiotechnology.26.93 · Cited by 59 · see citing works
Liu, J., Zhong, Y., Sun, Z., Huang, J., Sandmann, G., & Chen, F. (2010) · Planta · doi:10.1007/s00425-010-1132-y · Cited by 59 · see citing works
Tan, S. Y., Cunningham, F. X., Youmans, M., Grabowski, B., Sun, Z., & Gantt, E. (1995) · Journal of Phycology · doi:10.1111/j.0022-3646.1995.00897.x · Cited by 58 · see citing works
Fatty acid composition of some esterified carotenols
Renstrøm, B., & Liaaen‐Jensen, S. (1981) · Comparative Biochemistry and Physiology Part B Comparative Biochemistry · doi:10.1016/0305-0491(81)90360-6 · Cited by 58 · see citing works
Ryu, J.-Y., Song, J.-Y., Lee, J., Jeong, S. W., Chow, W. S., Choi, S.-B., Pogson, B. J., & Park, Y. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m402541200 · Cited by 57 · see citing works
Growth-associated biosynthesis of astaxanthin in heterotrophic Chlorella zofingiensis (Chlorophyta)
Wang, Y., & Peng, J. (2008) · World Journal of Microbiology and Biotechnology · doi:10.1007/s11274-008-9692-8 · Cited by 57 · see citing works
The GHOST terminal oxidase regulates developmental programming in tomato fruit
Barr, J., White, W. S., Chen, L., BAE, H., & Rodermel, S. R. (2004) · Plant Cell & Environment · doi:10.1111/j.1365-3040.2004.01190.x · Cited by 56 · see citing works
Occurrence of Astaxanthin in the Flower Petals of Adonis annua L.
Seybold, A., & Goodwin, T. W. (1959) · Nature · doi:10.1038/1841714a0 · Cited by 56 · see citing works
Hoham, R. W., & Mullet, J. E. (1977) · Phycologia · doi:10.2216/i0031-8884-16-1-53.1 · Cited by 54 · see citing works
Two-step process for ketocarotenoid production by a green alga, Chlorococcum sp. strain MA-1
Zhang, D.-H., & Lee, Y.-K. (2001) · Applied Microbiology and Biotechnology · doi:10.1007/s002530000526 · Cited by 51 · see citing works
Cell wall carotenoids in green algae which form sporopollenins
Burczyk, J. (1986) · Phytochemistry · doi:10.1016/s0031-9422(00)81494-6 · Cited by 51 · see citing works
Brinda, B. R., Sarada, R., Kamath, B. S., & Ravishankar, G. A. (2004) · CFTRI Institutional Repository · Cited by 49 · see citing works
Carotenoids in photosynthesis: Protection of D1 degradation in the light
Sandmann, G., Kuhn, M. G., & B�ger, P. (1993) · Photosynthesis Research · doi:10.1007/bf00014749 · Cited by 48 · see citing works
Development of Red Pigmentation in Chlorococcum wimmeri (Chlorophyta: Chlorococcales)
Brown, T. E., Richardson, F. L., & Vaughn, M. L. (1967) · Phycologia · doi:10.2216/i0031-8884-6-4-167.1 · Cited by 47 · see citing works
Inhibition of astaxanthin synthesis in the green alga,Haematococcus pluvialis
Harker, M., & Young, A. J. (1995) · European Journal of Phycology · doi:10.1080/09670269500650961 · Cited by 47 · see citing works
Levy, H., Gokhman, I., & Zamir, A. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)37036-x · Cited by 45 · see citing works
SECONDARY CAROTENOID ACCUMULATION IN <i>SCENEDESMUS KOMAREKII</i> (CHLOROPHYCEAE, CHLOROPHYTA)
Hanagata, N., & Dubinsky, Z. (1999) · Journal of Phycology · doi:10.1046/j.1529-8817.1999.3550960.x · Cited by 43 · see citing works
Secondary carotenoid accumulation in flagellates of the green algaHaematococcus lacustris
Grünewald, K., Hagen, C., & Braune, W. (1997) · European Journal of Phycology · doi:10.1080/09670269710001737329 · Cited by 43 · see citing works
Nuclear–chloroplast signalling
Somanchi, A., & Mayfield, S. P. (1999) · Current Opinion in Plant Biology · doi:10.1016/s1369-5266(99)00013-8 · Cited by 42 · see citing works
Esterified, optical pure (3S, 3′S)-astaxanthin from flowers of Adonis annua
Renstrøm, B., Berger, H., & Liaaen‐Jensen, S. (1981) · Biochemical Systematics and Ecology · doi:10.1016/0305-1978(81)90003-x · Cited by 42 · see citing works
Grünewald, K., & Hagen, C. (2001) · Journal of Applied Phycology · doi:10.1023/a:1008183328839 · Cited by 39 · see citing works
Hagen, C., Braune, W., Birckner, E., & Nüske, J. (1993) · New Phytologist · doi:10.1111/j.1469-8137.1993.tb03912.x · Cited by 39 · see citing works
Chlorophyll and carotenoid analysis in food products. A practical case-by-case view
Schoefs, B. (2003) · TrAC Trends in Analytical Chemistry · doi:10.1016/s0165-9936(03)00602-2 · Cited by 39 · see citing works
Self-citationMicroalgae as a source for secondary carotenoid production: a screening study
Kopecký, J., Schoefs, B., Loest, K., Štys, D., & Pulz, O. (2000) · Algological Studies/Archiv für Hydrobiologie Supplement Volumes · doi:10.1127/algol_stud/98/2000/153 · Cited by 32 · see citing works
Self-citationRaman, V., Sarada, R., & Ravishankar, G. A. (2009) · Enzyme and Microbial Technology · doi:10.1016/j.enzmictec.2009.05.005 · Cited by 30 · see citing works
Cloning and Characterization of β-Carotene Ketolase Gene Promoter in Haematococcus pluvialis
Meng, C., Chang-ying, T., Jiang, P., Qin, S., & Tseng, C. (2005) · Acta Biochimica et Biophysica Sinica · doi:10.1111/j.1745-7270.2005.00033.x · Cited by 30 · see citing works
A zeaxanthin protein from Anacystis nidulans
Diversé-Pierluissi, M. A., & Krogmann, D. W. (1988) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/0005-2728(88)90045-x · Cited by 29 · see citing works
Tran, N.-P., Park, J.-K., & Lee, C. (2009) · Enzyme and Microbial Technology · doi:10.1016/j.enzmictec.2009.07.006 · Cited by 29 · see citing works
Methylerythritol Phosphate Pathway
Rohmer, M. (2010) · Elsevier eBooks · doi:10.1016/b978-008045382-8.00702-4 · Cited by 29 · see citing works
Carotenoid hydroxylation – P450 finally!
INOUE, K. (2004) · Trends in Plant Science · doi:10.1016/j.tplants.2004.09.001 · Cited by 28 · see citing works
Carotenoids and Stress in Higher Plants and Algae
Rmiki, N.-E., Schoefs, B., & Lemoine, Y. (1999) · Books in soils, plants, and the environment · doi:10.1201/9780824746728.ch20 · Cited by 28 · see citing works
Self-citationQiu, B., & Li, Y. (2006) · Phycologia · doi:10.2216/04-99.1 · Cited by 26 · see citing works
Biosynthesis of Carotenoids in the Chloroplasts of Algae and Higher Plants
Ladygin, V. G. (2000) · Russian Journal of Plant Physiology · doi:10.1023/a:1026667430591 · Cited by 25 · see citing works
Abe, K., TAKIZAWA, H., Kimura, S., & Hirano, M. (2004) · Journal of Bioscience and Bioengineering · doi:10.1016/s1389-1723(04)70239-x · Cited by 25 · see citing works
Saccharides of Different Varieties of Indian Rice
Parihar, D. B. (1955) · Nature · doi:10.1038/175042b0 · Cited by 25 · see citing works
Phillips, L. G., Cowan, A. K., Rose, P. D., & Logie, M. R. R. (1995) · Journal of Plant Physiology · doi:10.1016/s0176-1617(11)82022-5 · Cited by 24 · see citing works
Bjerkeng, B. (1997) · The Progressive Fish-Culturist · doi:10.1577/1548-8640(1997)059 · Cited by 23 · see citing works
Tischer, J. (1936) · Hoppe-Seyler´s Zeitschrift für physiologische Chemie · doi:10.1515/bchm2.1936.239.4-6.257 · Cited by 23 · see citing works
Flagged first, then by citations
1 of the 215 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Khan, M. I., Shin, J. H., & Kim, J. D. (2018) · Microbial Cell Factories · doi:10.1186/s12934-018-0879-x · Cited by 2,082 · see citing works
High-value products from microalgae—their development and commercialisation
Borowitzka, M. A. (2013) · Journal of Applied Phycology · doi:10.1007/s10811-013-9983-9 · Cited by 1,585 · see citing works
Markou, G., & Nerantzis, E. (2013) · Biotechnology Advances · doi:10.1016/j.biotechadv.2013.07.011 · Cited by 815 · see citing works
Carotenoids in Algae: Distributions, Biosyntheses and Functions
Takaichi, S. (2011) · Marine Drugs · doi:10.3390/md9061101 · Cited by 809 · see citing works
Maltsev, Y., Maltseva, K., Kulikovskiy, M., & Maltseva, S. (2021) · Biology · doi:10.3390/biology10101060 · Cited by 511 · see citing works
Cuellar‐Bermudez, S. P., Aguilar‐Hernandez, I., Cardenas‐Chavez, D. L., Ornelas‐Soto, N., Romero‐Ogawa, M. A., & Parra‐Saldivar, R. (2015) · Microbial Biotechnology · doi:10.1111/1751-7915.12167 · Cited by 486 · see citing works
Sathasivam, R., & Ki, J. (2018) · Marine Drugs · doi:10.3390/md16010026 · Cited by 481 · see citing works
Photosynthesis under artificial light: the shift in primary and secondary metabolism
Darko, E., Heydarizadeh, P., Schoefs, B., & Sabzalian, M. R. (2014) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2013.0243 · Cited by 449 · see citing works
Self-citationMinhas, A. K., Hodgson, P., Barrow, C. J., & Adholeya, A. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.00546 · Cited by 451 · see citing works
Astaxanthin as feed supplement in aquatic animals
Lim, K. C., Yusoff, F. M., Shariff, M., & Kamarudin, M. S. (2017) · Reviews in Aquaculture · doi:10.1111/raq.12200 · Cited by 449 · see citing works
Carotenoids, versatile components of oxygenic photosynthesis
Domonkos, I., Kis, M., Gombos, Z., & Ughy, B. (2013) · Progress in Lipid Research · doi:10.1016/j.plipres.2013.07.001 · Cited by 310 · see citing works
Phototrophic pigment production with microalgae: biological constraints and opportunities
Mulders, K. J. M., Lamers, P. P., Martens, D. E., & Wijffels, R. H. (2014) · Journal of Phycology · doi:10.1111/jpy.12173 · Cited by 302 · see citing works
Concepts and studies on lipid and pigments of microalgae: A review
D’Alessandro, E. B., & Antoniosi Filho, N. R. (2016) · Renewable and Sustainable Energy Reviews · doi:10.1016/j.rser.2015.12.162 · Cited by 289 · see citing works
The Potential of Microalgae for the Production of Bioactive Molecules of Pharmaceutical Interest
Mimouni, V., Ulmann, L., Pasquet, V., Mathieu, M., Picot, L., Bougaran, G., Cadoret, J., Morant-Manceau, A., & Schoefs, B. (2012) · Current Pharmaceutical Biotechnology · doi:10.2174/138920112804724828 · Cited by 274 · see citing works
Self-citationAstaxanthin in microalgae: pathways, functions and biotechnological implications
Han, D., Li, Y., & Hu, Q. (2013) · ALGAE · doi:10.4490/algae.2013.28.2.131 · Cited by 263 · see citing works
Isoprenoid biosynthesis in eukaryotic phototrophs: A spotlight on algae
Lohr, M., Schwender, J., & Polle, J. E. W. (2011) · Plant Science · doi:10.1016/j.plantsci.2011.07.018 · Cited by 244 · see citing works
“Therapeutic uses of natural astaxanthin: An evidence-based review focused on human clinical trials”
Donoso, A., González-Durán, J., Agurto-Muñoz, A., González, P. A., & Agurto-Muñoz, C. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.105479 · Cited by 246 · see citing works
Physiological role of neutral lipid accumulation in eukaryotic microalgae under stresses
Solovchenko, A. E. (2012) · Russian Journal of Plant Physiology · doi:10.1134/s1021443712020161 · Cited by 236 · see citing works
Chen, G., Wang, B., Han, D., Sommerfeld, M. R., Lu, Y., Chen, F., & Hu, Q. (2014) · The Plant Journal · doi:10.1111/tpj.12713 · Cited by 234 · see citing works
Biotechnological production of astaxanthin from the microalga Haematococcus pluvialis
Li, X., Wang, X., Duan, C., Yi, S., Gao, Z., Xiao, C., Agathos, S. N., Wang, G., & Li, J. (2020) · Biotechnology Advances · doi:10.1016/j.biotechadv.2020.107602 · Cited by 221 · see citing works
Impact of nutrient stress on antioxidant production in three species of microalgae
Goiris, K., Colen, W. V., Wilches, I., León-Tamaríz, F., Cooman, L. D., & Muylaert, K. (2014) · Algal Research · doi:10.1016/j.algal.2014.12.002 · Cited by 214 · see citing works
Wayama, M., Ota, S., Matsuura, H., Nango, N., Hirata, A., & Kawano, S. (2013) · PLoS ONE · doi:10.1371/journal.pone.0053618 · Cited by 206 · see citing works
Potential of Microalgae Carotenoids for Industrial Application
Cezare-Gomes, E. A., Mejia-da-Silva, L. D. C., Mora, L. S. P., Matsudo, M. C., Ferreira‐Camargo, L. S., Singh, A. K., & de Carvalho, J. C. M. (2019) · Applied Biochemistry and Biotechnology · doi:10.1007/s12010-018-02945-4 · Cited by 198 · see citing works
Gwak, Y., Hwang, Y., Wang, B., Kim, M., Jeong, J., Lee, C., Hu, Q., Han, D., & Jin, E. (2014) · Journal of Experimental Botany · doi:10.1093/jxb/eru206 · Cited by 194 · see citing works
Stresses as First-Line Tools for Enhancing Lipid and Carotenoid Production in Microalgae
Shi, T.-Q., Wang, L.-R., Zhang, Z.-X., Sun, X.-M., & Huang, H. (2020) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2020.00610 · Cited by 182 · see citing works
Roth, M., Cokus, S. J., Gallaher, S. D., Walter, A., Lopez, D., Erickson, E., Endelman, B., Westcott, D. J., Larabell, C. A., Merchant, S., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1619928114 · Cited by 179 · see citing works
Microalgae in the postgenomic era: a blooming reservoir for new natural products
Sasso, S., Pohnert, G., Lohr, M., Mittag, M., & Hertweck, C. (2011) · FEMS Microbiology Reviews · doi:10.1111/j.1574-6976.2011.00304.x · Cited by 171 · see citing works
Saini, R. K., & Keum, Y. (2018) · Journal of Industrial Microbiology & Biotechnology · doi:10.1007/s10295-018-2104-7 · Cited by 158 · see citing works
Carotenoid Distribution in Living Cells of Haematococcus pluvialis (Chlorophyceae)
Collins, A. M., Jones, H. D. T., Han, D., Hu, Q., Beechem, T. E., & Timlin, J. A. (2011) · PLoS ONE · doi:10.1371/journal.pone.0024302 · Cited by 157 · see citing works
Bioactive compounds in microalgae and their potential health benefits
Zhou, L., Li, K., Duan, X., Hill, D., Barrow, C., Dunshea, F., Martin, G., & Suleria, H. (2022) · Food Bioscience · doi:10.1016/j.fbio.2022.101932 · Cited by 150 · see citing works
Recent breakthroughs in the biology of astaxanthin accumulation by microalgal cell
Solovchenko, A. E. (2015) · Photosynthesis Research · doi:10.1007/s11120-015-0156-3 · Cited by 147 · see citing works
Over-accumulation of astaxanthin in Haematococcus pluvialis through chloroplast genetic engineering
Galarza, J. I., Gimpel, J. A., Rojas, V., Arredondo-Vega, B. O., & Henríquez, V. (2018) · Algal Research · doi:10.1016/j.algal.2018.02.024 · Cited by 143 · see citing works
Enhancing production of microalgal biopigments through metabolic and genetic engineering
Saini, D. K., Chakdar, H., Pabbi, S., & Shukla, P. (2019) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2018.1533518 · Cited by 143 · see citing works
Kalra, R., Gaur, S., & Goel, M. (2021) · Journal of Water Process Engineering · doi:10.1016/j.jwpe.2020.101794 · Cited by 140 · see citing works
Recht, L., Töpfer, N., Batushansky, A., Sikron, N., Gibon, Y., Fait, A., Nikoloski, Z., Boussiba, S., & Zarka, A. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.555144 · Cited by 136 · see citing works
Osundeko, O., Dean, A. P., Davies, H. S., & Pittman, J. K. (2014) · Plant and Cell Physiology · doi:10.1093/pcp/pcu113 · Cited by 133 · see citing works
Jannel, S., Caro, Y., Bermudes, M., & Petit, T. (2020) · Journal of Marine Science and Engineering · doi:10.3390/jmse8100789 · Cited by 132 · see citing works
Александрович, Ч. К., Lobakova, E. S., Selyakh, I., Semenova, L. R., Sidorov, R. A., & Solovchenko, A. E. (2014) · Marine Drugs · doi:10.3390/md12084504 · Cited by 129 · see citing works
Photosynthetic response to nitrogen starvation and high light in Haematococcus pluvialis
Scibilia, L., Girolomoni, L., Berteotti, S., Alboresi, A., & Ballottari, M. (2015) · Algal Research · doi:10.1016/j.algal.2015.08.024 · Cited by 127 · see citing works
Microalgae as a Source of Valuable Phenolic Compounds and Carotenoids
Cichoński, J., & Chrzanowski, G. (2022) · Molecules · doi:10.3390/molecules27248852 · Cited by 129 · see citing works
Diatom Milking: A Review and New Approaches
Vinayak, V., Manoylov, K. M., Gâteau, H., Blanckaert, V. D., Hérault, J., Pencreach, G., Marchand, J., Gordon, R., & Schoefs, B. (2015) · Marine Drugs · doi:10.3390/md13052629 · Cited by 126 · see citing works
Self-citationHong, M.-E., Hwang, S. K., Chang, W. S., Kim, B. W., Lee, J., & Sim, S. J. (2015) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-015-6440-5 · Cited by 125 · see citing works
Carotenoid Production by Dunaliella salina under Red Light
Xu, Y., & Harvey, P. J. (2019) · Antioxidants · doi:10.3390/antiox8050123 · Cited by 125 · see citing works
Le Goff, M., Le Ferrec, E., Mayer, C., Mimouni, V., Lagadic-Gossmann, D., Schoefs, B., & Ulmann, L. (2019) · Biochimie · doi:10.1016/j.biochi.2019.09.012 · Cited by 123 · see citing works
Self-citationNair, A., Ahirwar, A., Singh, S., Lodhi, R., Lodhi, A., Rai, A., Jadhav, D. A., Mangesh, H., Varjani, S., Singh, G., et al. (2023) · Marine Drugs · doi:10.3390/md21030176 · Cited by 127 · see citing works
Self-citationPlant Biostimulants to Enhance Abiotic Stress Resilience in Crops
Sario, L. D., Boeri, P. A., Matus, J. T., & Pizzio, G. A. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26031129 · Cited by 147 · see citing works
Biosynthesis of Triacylglycerols (TAGs) in Plants and algae
Cagliari, A., Margis, R., Maraschin, F. D. S., Turchetto‐Zolet, A. C., Loss, G., & Margis-Pinheiro, M. M. A. N. (2011) · International Journal of Plant Biology · doi:10.4081/pb.2011.e10 · Cited by 122 · see citing works
Abiotic stress in algae: response, signaling and transgenic approaches
Kaur, M., Saini, K. C., Ojah, H., Sahoo, R., Gupta, K., Kumar, A., & Bast, F. (2022) · Journal of Applied Phycology · doi:10.1007/s10811-022-02746-7 · Cited by 116 · see citing works
Sandmann, G. (2021) · New Phytologist · doi:10.1111/nph.17655 · Cited by 118 · see citing works
Plastids of Marine Phytoplankton Produce Bioactive Pigments and Lipids
Heydarizadeh, P., Poirier, I., Loizeau, D., Ulmann, L., Mimouni, V., Schoefs, B., & Bertrand, M. (2013) · Marine Drugs · doi:10.3390/md11093425 · Cited by 117 · see citing works
Self-citationHenríquez, V., Escobar, C., Galarza, J. I., & Gimpel, J. A. (2016) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-3-319-39126-7_8 · Cited by 112 · see citing works
Su, Y., Wang, J., Shi, M., Niu, X., Yu, X., Gao, L., Zhang, X., Chen, L., & Zhang, W. (2014) · Bioresource Technology · doi:10.1016/j.biortech.2014.08.018 · Cited by 107 · see citing works
Lafarga, T. (2019) · Food Reviews International · doi:10.1080/87559129.2019.1655572 · Cited by 108 · see citing works
Mao, X., Zhang, Y., Wang, X., & Liu, J. (2020) · Biotechnology for Biofuels · doi:10.1186/s13068-020-01714-y · Cited by 104 · see citing works
Occurrence and biosynthesis of carotenoids in phytoplankton
Huang, J. J., Lin, S., Xu, W., & Cheung, P. C. K. (2017) · Biotechnology Advances · doi:10.1016/j.biotechadv.2017.05.001 · Cited by 104 · see citing works
Tamaki, S., Mochida, K., & Suzuki, K. (2021) · Plants · doi:10.3390/plants10061250 · Cited by 104 · see citing works
Innovative Microalgae Pigments as Functional Ingredients in Nutrition
Christaki, E. V., Bonos, E., & Florou-Paneri, P. C. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-800776-1.00014-5 · Cited by 103 · see citing works
When Unity Is Strength: The Strategies Used by Chlamydomonas to Survive Environmental Stresses
de Carpentier, F., Lemaire, S. D., & Danon, A. (2019) · Cells · doi:10.3390/cells8111307 · Cited by 103 · see citing works
Ota, S., Morita, A., Ohnuki, S., Hirata, A., Sekida, S., Okuda, K., Ohya, Y., & Kawano, S. (2018) · Scientific Reports · doi:10.1038/s41598-018-23854-w · Cited by 102 · see citing works
Carotenoids of Microalgae Used in Food Industry and Medicine
Gâteau, H., Solymosi, K., Marchand, J., & Schoefs, B. (2016) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/1389557516666160808123841 · Cited by 101 · see citing works
Self-citationDebnath, T., Bandyopadhyay, T. K., Vanitha, K., Bobby, M. N., Tiwari, O. N., Bhunia, B., & Muthuraj, M. (2023) · Food Research International · doi:10.1016/j.foodres.2023.113841 · Cited by 101 · see citing works
Ghazani, S. M., & Marangoni, A. G. (2021) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2021.10.014 · Cited by 96 · see citing works
Food colour additives of natural origin
Solymosi, K., Latruffe, N., Morant-Manceau, A., & Schoefs, B. (2015) · Elsevier eBooks · doi:10.1016/b978-1-78242-011-8.00001-5 · Cited by 93 · see citing works
Self-citationKou, Y., Liu, M., Sun, P., Dong, Z., & Liu, J. (2020) · Algal Research · doi:10.1016/j.algal.2020.101976 · Cited by 94 · see citing works
Cadmium, Copper, Sodium and Zinc Effects on Diatoms: from Heaven to Hell — a Review
Masmoudi, S., Nguyen-Deroche, N., Caruso, A., Ayadi, H., Morant-Manceau, A., Tremblin, G., Martine, & Schoefs, B. (2013) · Cryptogamie Algologie · doi:10.7872/crya.v34.iss2.2013.185 · Cited by 92 · see citing works
Self-citationRemias, D., Wastian, H., Lütz, C., & Leya, T. (2013) · Antarctic Science · doi:10.1017/s0954102013000060 · Cited by 90 · see citing works
Pick, U., Zarka, A., Boussiba, S., & Davidi, L. (2018) · Planta · doi:10.1007/s00425-018-3050-3 · Cited by 87 · see citing works
Zhang, Y., Ye, Y., Ding, W., Mao, X., Li, Y., Gerken, H. G., & Liu, J. (2020) · PLANT PHYSIOLOGY · doi:10.1104/pp.20.00325 · Cited by 90 · see citing works
Gao, Z., Meng, C., Zhang, X., Xu, D., Zhao, Y., Wang, Y., Lv, H., Yang, L., Chen, L., & Ye, N. (2012) · PLoS ONE · doi:10.1371/journal.pone.0042243 · Cited by 90 · see citing works
Guihéneuf, F., Khan, A. A., & Tran, L. P. (2016) · Frontiers in Plant Science · doi:10.3389/fpls.2016.00400 · Cited by 89 · see citing works
Ding, W., Zhao, P., Peng, J., Zhao, Y., Xu, J., Li, T., Reiter, R. J., Ma, H., & Yu, X. (2018) · Algal Research · doi:10.1016/j.algal.2018.05.021 · Cited by 89 · see citing works
Wang, F., Gao, B., Wu, M., Huang, L., & Zhang, C. (2019) · Algal Research · doi:10.1016/j.algal.2019.101466 · Cited by 87 · see citing works
Reprogramming microorganisms for the biosynthesis of astaxanthin via metabolic engineering
Wan, X., Zhou, X., Moncalián, G., Su, L. C., Chen, W., Zhu, H.-Z., Chen, D., Gong, Y., Huang, F., & Deng, Q. (2020) · Progress in Lipid Research · doi:10.1016/j.plipres.2020.101083 · Cited by 87 · see citing works
Mulders, K. J. M., Janssen, J. H., Martens, D. E., Wijffels, R. H., & Lamers, P. P. (2014) · Algal Research · doi:10.1016/j.algal.2014.08.006 · Cited by 85 · see citing works
Carotenoid Distribution in Nature
Alcaı́no, J., Baeza, M., & Cifuentes, V. (2016) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-3-319-39126-7_1 · Cited by 85 · see citing works
Hu, C., Cui, D., Sun, X. K., Shi, J., & Xu, N. (2019) · Algal Research · doi:10.1016/j.algal.2019.101768 · Cited by 81 · see citing works
Physiology and adaptive significance of secondary carotenogenesis in green microalgae
Solovchenko, A. E. (2012) · Russian Journal of Plant Physiology · doi:10.1134/s1021443713010081 · Cited by 82 · see citing works
Microalgal Carotenoids: Therapeutic Application and Latest Approaches to Enhance the Production
Sirohi, P., Verma, H., Singh, S. K., Singh, V. K., Pandey, J., Khusharia, S., Kumar, D., Kaushalendra, K., Teotia, P., & Kumar, A. (2022) · Current Issues in Molecular Biology · doi:10.3390/cimb44120427 · Cited by 85 · see citing works
Pichrtová, M., Remias, D., Lewis, L. A., & Holzinger, A. (2012) · Microbial Ecology · doi:10.1007/s00248-012-0096-9 · Cited by 80 · see citing works
Snow and ice ecosystems: not so extreme
Maccario, L., Casado, L. S., Vogel, T. M., & Larose, C. (2015) · Research in Microbiology · doi:10.1016/j.resmic.2015.09.002 · Cited by 76 · see citing works
Zhang, Y., Ye, Y., Bai, F., & Liu, J. (2021) · Biotechnology for Biofuels · doi:10.1186/s13068-021-01969-z · Cited by 77 · see citing works
Nguyen-Deroche, T. L. N., Caruso, A., Le, T. T., Bui, T. V., Schoefs, B., Tremblin, G., & Morant-Manceau, A. (2012) · The Scientific World JOURNAL · doi:10.1100/2012/982957 · Cited by 74 · see citing works
Self-citationAburai, N., Ohkubo, S., Miyashita, H., & Abe, K. (2013) · Algal Research · doi:10.1016/j.algal.2013.03.001 · Cited by 73 · see citing works
Lutz, S., Anesio, A. M., Field, K. J., & Benning, L. G. (2015) · Frontiers in Microbiology · doi:10.3389/fmicb.2015.01323 · Cited by 73 · see citing works
Mulders, K. J. M., Weesepoel, Y., Bodénès, P., Lamers, P. P., Vincken, J., Martens, D. E., Gruppen, H., & Wijffels, R. H. (2014) · Journal of Applied Phycology · doi:10.1007/s10811-014-0333-3 · Cited by 74 · see citing works
Gao, Z., Li, Y., Wu, G., Li, G., Sun, H., Deng, S., Shen, Y., Chen, G., Zhang, R., Meng, C., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0140609 · Cited by 70 · see citing works
Aburai, N., Sumida, D., & Abe, K. (2015) · Algal Research · doi:10.1016/j.algal.2015.01.005 · Cited by 70 · see citing works
Solovchenko, A. E., Lukyanov, A., Solovchenko, O. V., Didi‐Cohen, S., Boussiba, S., & Khozin‐Goldberg, I. (2014) · European Journal of Lipid Science and Technology · doi:10.1002/ejlt.201300456 · Cited by 69 · see citing works
Kim, Y.-E., Matter, I. A., Lee, N., Jung, M., Lee, Y., Choi, S.-A., Lee, S. Y., Kim, J. R., & Oh, Y. (2020) · Bioresource Technology · doi:10.1016/j.biortech.2020.123270 · Cited by 68 · see citing works
Minyuk, G., Sidorov, R., & Solovchenko, A. (2020) · Journal of Applied Phycology · doi:10.1007/s10811-020-02060-0 · Cited by 67 · see citing works
Cvetkovska, M., Hüner, N. P. A., & Smith, D. R. (2016) · Polar Biology · doi:10.1007/s00300-016-2045-4 · Cited by 66 · see citing works
Orona-Navar, A., Aguilar-Hernández, I., Nigam, K. D. P., Cerdán-Pasarán, A., & Ornelas-Soto, N. (2021) · Journal of Biotechnology · doi:10.1016/j.jbiotec.2021.03.013 · Cited by 64 · see citing works
Elloumi, W., Jebali, A., Maalej, A., Chamkha, M., & Sayadi, S. (2020) · Biomolecules · doi:10.3390/biom10111515 · Cited by 64 · see citing works
Hong, M.-E., Choi, Y. Y., & Sim, S. J. (2015) · Journal of Biotechnology · doi:10.1016/j.jbiotec.2015.11.019 · Cited by 64 · see citing works
Zhang, L., Zhang, C., Liu, J., & Yang, N. (2019) · Algal Research · doi:10.1016/j.algal.2019.101779 · Cited by 63 · see citing works
Diversity and Distribution of Carotenogenic Algae in Europe: A Review
Александрович, Ч. К. (2023) · Marine Drugs · doi:10.3390/md21020108 · Cited by 63 · see citing works
Gu, W., Li, H., Zhao, P., Yu, R., Pan, G., Gao, S., Xie, X., Huang, A., He, L., & Wang, G. (2014) · Scientific Reports · doi:10.1038/srep06661 · Cited by 62 · see citing works
Remias, D., Pichrtová, M., Pangratz, M., Lütz, C., & Holzinger, A. (2016) · FEMS Microbiology Ecology · doi:10.1093/femsec/fiw030 · Cited by 62 · see citing works
Carotenogenic response in photosynthetic organisms: a colorful story
Solovchenko, A. E., & Neverov, K. V. (2017) · Photosynthesis Research · doi:10.1007/s11120-017-0358-y · Cited by 62 · see citing works
Gâteau, H., Blanckaert, V. D., Veidl, B., Burlet‐Schiltz, O., Pichereaux, C., Gargaros, A., Marchand, J., & Schoefs, B. (2020) · Bioelectrochemistry · doi:10.1016/j.bioelechem.2020.107588 · Cited by 61 · see citing works
Self-citation
- Authors
- Lemoine, Y., & Schoefs, B.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Venue
- Photosynthesis Research
- Published
- 2010-08-13
- Volume
- 106
- Issue
- 1-2
- Pages
- 155-177
- ISSN
- 0166-8595 (ISSN-L)
- 1573-5079
- OpenAlex
- W1991026527
- Cited by
- 384
- References
- 215
- Citations by year
- 2026: 15 · 2025: 26 · 2024: 21 · 2023: 25 · 2022: 28 · 2021: 50 · 2020: 42 · 2019: 31 · 2018: 25 · 2017: 17 · 2016: 20 · 2015: 20 · 2014: 26 · 2013: 21 · 2012: 9
- FWCI
- 0.42
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- other-oa
- www.springer.com/tdm (tdm)
- Locations
- Photosynthesis Research (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- LillOA (Université de Lille (University Of Lille)) (submittedVersion, other-oa)
- Topics
- Physical Sciences › Energy › Renewable Energy, Sustainability and the Environment › Algal biology and biofuel production
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Plant biochemistry and biosynthesis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Photosynthetic Processes and Mechanisms
- Keywords
- astaxanthin biosynthesis, ketocarotenoids, Haematococcus pluvialis, carotenogenesis, oxidative stress, antioxidant activity, red snow, cyst formation, UV-B stress, light stress, metabolic regulation, green algae
- MeSH terms
- Chlorophyta, Carotenoids, Stress, Physiological, Plastids, Xanthophylls, Biosynthetic Pathways, Eukaryota
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