The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Quorum Sensing in the Dimorphic Fungus Candida albicans Is Mediated by Farnesol
Open accessAbstract
The inoculum size effect in the dimorphic fungus Candida albicans results from production of an extracellular quorum-sensing molecule (QSM). This molecule prevents mycelial development in both a growth morphology assay and a differentiation assay using three chemically distinct triggers for germ tube formation (GTF): L-proline, N-acetylglucosamine, and serum (either pig or fetal bovine). In all cases, the presence of QSM prevents the yeast-to-mycelium conversion, resulting in actively budding yeasts without influencing cellular growth rates. QSM exhibits general cross-reactivity within C. albicans in that supernatants from strain A72 are active on five other strains of C. albicans and vice versa. The QSM excreted by C. albicans is farnesol (C(15)H(26)O; molecular weight, 222.37). QSM is extracellular, and is produced continuously during growth and over a temperature range from 23 to 43 degrees C, in amounts roughly proportional to the CFU/milliliter. Production is not dependent on the type of carbon source nor nitrogen source or on the chemical nature of the growth medium. Both commercial mixed isomer and (E,E)-farnesol exhibited QSM activity (the ability to prevent GTF) at a level sufficient to account for all the QSM activity present in C. albicans supernatants, i.e., 50% GTF at ca. 30 to 35 microM. Nerolidol was ca. two times less active than farnesol. Neither geraniol (C(10)), geranylgeraniol (C(20)), nor farnesyl pyrophosphate had any QSM activity.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“In the biofilm environment, Candida species cells have the ability to communicate with each other via quorum sensing (via numerous signalling molecules), which is directly dependent on the cell density [148].”
From Candida glabrata Biofilms: How Far Have We Come? (2017) · cites this paper as [148]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Handbook of Microbiological Media
Atlas, R. M., & Atlas, R. M. (2004) · CRC Press eBooks · doi:10.1201/9781420039726 · Cited by 2,162
Nonfilamentous C. albicans Mutants Are Avirulent
Lo, H.-J., Köhler, J. R., DiDomenico, B., Loebenberg, D., Cacciapuoti, A., & Fink, G. R. (1997) · Cell · doi:10.1016/s0092-8674(00)80358-x · Cited by 1,809
Lee, K. L., BUCKLEY, H. R., & Campbell, C. C. (1975) · Medical Mycology · doi:10.1080/00362177585190271 · Cited by 791
Shaw, P. D., Ping, G., Daly, S. L., Cha, C., Cronan, J. E., RINEHART, K. L. J., & Farrand, S. K. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.12.6036 · Cited by 748
Cha, C., Gao, P. H., Chen, Y.-C., Shaw, P. D., & Farrand, S. K. (1998) · Molecular Plant-Microbe Interactions · doi:10.1094/mpmi.1998.11.11.1119 · Cited by 618
Brown‐Borg, H. M. (1995) · Tissue and Cell · doi:10.1016/s0040-8166(05)80072-2 · Cited by 511
Evidence for Mating of the "Asexual" Yeast Candida albicans in a Mammalian Host
Hull, C. M., Raisner, R. M., & Johnson, A. D. (2000) · Science · doi:10.1126/science.289.5477.307 · Cited by 465
Induction of Mating in Candida albicans by Construction of MTL a and MTL α Strains
Magee, B. B., & Magee, P. T. (2000) · Science · doi:10.1126/science.289.5477.310 · Cited by 443
Regulatory networks controlling Candida albicans morphogenesis
Brown, A. J. P., & Gow, N. A. R. (1999) · Trends in Microbiology · doi:10.1016/s0966-842x(99)01556-5 · Cited by 300
Yeast-mycelial conversion induced by N-acetyl-D-glucosamine in Candida albicans
Simonetti, N., Strippoli, V., & Cassone, A. (1974) · Nature · doi:10.1038/250344a0 · Cited by 220
Fungal Nutrition and Physiology
Garraway, M. O., & Evans, R. C. (1984) · Medical Entomology and Zoology · Cited by 205
Tempé, J., Petit, A., Holsters, M., MONTAGU, M. V., & Schell, J. (1977) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.74.7.2848 · Cited by 190
Geraniol interferes with membrane functions in strains ofCandida andSaccharomyces
Bard, M., Albrecht, M. R., Gupta, N., Guynn, C. J., & Stillwell, W. H. (1988) · Lipids · doi:10.1007/bf02535593 · Cited by 160
Fungal lipopeptide mating pheromones: a model system for the study of protein prenylation
Caldwell, G. A., Naider, F. R., & Becker, J. M. (1995) · Microbiological Reviews · doi:10.1128/mr.59.3.406-422.1995 · Cited by 106
Phenotypic variation and intracellular parasitism by Histoplasma capsulatum
Kügler, S., Sebghati, T. A., Eissenberg, L. G., & Goldman, W. E. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.16.8794 · Cited by 94
Nutritional control of dimorphism inCeratocystis ulmi
Kulkarni, R. K., & Nickerson, K. W. (1981) · Experimental Mycology · doi:10.1016/0147-5975(81)90015-3 · Cited by 94
Self-citationGermination of Candida albicans induced by proline
Dabrowa, N., Taxer, S. S., & Howard, D. H. (1976) · Infection and Immunity · doi:10.1128/iai.13.3.830-835.1976 · Cited by 88
de Repentigny, L., Phaneuf, M., & Mathieu, L. G. (1992) · Infection and Immunity · doi:10.1128/iai.60.11.4907-4914.1992 · Cited by 86
Voziyan, P., Haug, J. S., & Melnykovych, G. (1995) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1995.1995 · Cited by 72
Mode of action of essential oil components on whole cells of bacteria and fungi in plate tests
Knobloch, K., Pauli, A., Iberl, B., Weis, N., & Weigand, H. (1988) · De Gruyter eBooks · doi:10.1515/9783110867121-022 · Cited by 72
Chopra, A., & Khuller, G. K. (1983) · Progress in Lipid Research · doi:10.1016/0163-7827(83)90009-7 · Cited by 63
GENETIC BLOCK IN THE CELLULAR DIVISION MECHANISM OF A MORPHOLOGICAL MUTANT OF A YEAST
Nickerson, W. J., & Chung, C. W. (1954) · American Journal of Botany · doi:10.1002/j.1537-2197.1954.tb14313.x · Cited by 55
AN ENZYMATIC LOCUS PARTICIPATING IN CELLULAR DIVISION OF A YEAST
Nickerson, W. J. (1954) · The Journal of General Physiology · doi:10.1085/jgp.37.4.483 · Cited by 55
Gooday, G. W., & Adams, D. J. (1993) · Advances in microbial physiology/Advances in Microbial Physiology · doi:10.1016/s0065-2911(08)60028-4 · Cited by 47
Saisho, Y., Morimoto, A., & Umeda, T. (1997) · Analytical Biochemistry · doi:10.1006/abio.1997.2314 · Cited by 46
Isolation and Purification of Morphogenic Autoregulatory Substance Produced by Candida albicans1
Hazen, K. C., & Cutler, J. E. (1983) · The Journal of Biochemistry · doi:10.1093/oxfordjournals.jbchem.a134419 · Cited by 38
Candida albicansgerm-tube formation with immobilized GlcNAc
Shepherd, M. G., & Sullivan, P. A. (1983) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.1983.tb00395.x · Cited by 22
The Formation of Germ Tubes byCandida albicansin Sheep Serum and Trypticase Soya Broth
Joshi, K. R., Bremner, D. A., Gavin, J. B., Herdson, P. B., & Parr, D. (1973) · American Journal of Clinical Pathology · doi:10.1093/ajcp/60.6.839 · Cited by 19
Wise, M. L., Rossi, J. V., & Gerwick, W. H. (1997) · Biochemistry · doi:10.1021/bi962158v · Cited by 18
Barabote, R. D., Prasad, R., & Ghannocum, M. (1999) · Mycologia · doi:10.2307/3761361 · Cited by 17
-to- 2,3-double bond isomerization of epoxyfarnesol and farnesol by fungus
Suzuki, Y., & Marumo, S. (1972) · Tetrahedron Letters · doi:10.1016/s0040-4039(01)85180-7 · Cited by 15
Cho‐Shultz, S., Dussault, P. H., Lisec, A. D., Jensen, E. C., & Nickerson, K. W. (1999) · Journal of the Chemical Society Perkin Transactions 1 · doi:10.1039/a807417h · Cited by 13
Self-citationMishra, P., & Prasad, R. (1991) · Springer eBooks · doi:10.1007/978-3-642-75253-7_9 · Cited by 11
Research works printed but not linked: 3
- Coscia C. J. (1984) Handbook of chromatography: terpenoids. (CRC Press Boca Raton Fla).
- Griffin D. H. (1994) Fungal physiology (Wiley-Liss New York N. Y) 2nd ed.
- Lisec A. D. (1998) Quorum sensing in Candida albicans: partial purification of two extracellular candidate molecules. M.S. thesis. (University of Nebraska Lincoln).
Cited by
Sorted by citations
Candida albicans pathogenicity mechanisms
Mayer, F. L., Wilson, D., & Hube, B. (2013) · Virulence · doi:10.4161/viru.22913 · Cited by 1,848
Microbial interactions within the plant holobiont
Hassani, M. A., Durán, P., & Hacquard, S. (2018) · Microbiome · doi:10.1186/s40168-018-0445-0 · Cited by 1,480
Progress in and promise of bacterial quorum sensing research
Whiteley, M., Diggle, S. P., & Greenberg, E. P. (2017) · Nature · doi:10.1038/nature24624 · Cited by 1,306
Candida biofilms and their role in infection
Douglas, L. J. (2003) · Trends in Microbiology · doi:10.1016/s0966-842x(02)00002-1 · Cited by 1,150
Growth of Candida albicans hyphae
Sudbery, P. E. (2011) · Nature Reviews Microbiology · doi:10.1038/nrmicro2636 · Cited by 1,110
Metadata
- Authors
- Hornby, J. M., Jensen, E. C., Lisec, A. D., Tasto, J. J., Jahnke, B., Shoemaker, R., Dussault, P., & Nickerson, K. W.
- Affiliations
- University of Nebraska–Lincoln (US)
- College of Saint Benedict and Saint John's University (US)
- Venue
- Applied and Environmental Microbiology
- Publisher
- American Society for Microbiology
- Published
- 2001-07
- Volume
- 67
- Issue
- 7
- Pages
- 2982-2992
- ISSN
- 0099-2240 (ISSN-L)
- 1098-5336
- PMC
- PMC92970
- OpenAlex
- W2144677145
- Cited by
- 983
- References
- 33
- Citations by year
- 2026: 23 · 2025: 30 · 2024: 32 · 2023: 51 · 2022: 42 · 2021: 59 · 2020: 46 · 2019: 48 · 2018: 42 · 2017: 60 · 2016: 40 · 2015: 51 · 2014: 45 · 2013: 42 · 2012: 50
- FWCI
- 10.29
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Applied and Environmental Microbiology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Lincoln (University of Nebraska) (submittedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Keywords
- quorum sensing, Candida albicans, farnesol, dimorphic fungi, germ tube formation, mycelial development, extracellular signaling molecules, inoculum size effect, nerolidol, geranylgeraniol, geraniol, farnesyl pyrophosphate
- MeSH terms
- Candida albicans, Chromatography, High Pressure Liquid, Chromatography, Thin Layer, Culture Media, Farnesol, Hot Temperature, Gas Chromatography-Mass Spectrometry, Gene Expression Regulation, Fungal
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
