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Quorum Sensing in the Dimorphic Fungus Candida albicans Is Mediated by Farnesol
Open accessAbstract
The inoculum size effect in the dimorphic fungus Candida albicans results from production of an extracellular quorum-sensing molecule (QSM). This molecule prevents mycelial development in both a growth morphology assay and a differentiation assay using three chemically distinct triggers for germ tube formation (GTF): L-proline, N-acetylglucosamine, and serum (either pig or fetal bovine). In all cases, the presence of QSM prevents the yeast-to-mycelium conversion, resulting in actively budding yeasts without influencing cellular growth rates. QSM exhibits general cross-reactivity within C. albicans in that supernatants from strain A72 are active on five other strains of C. albicans and vice versa. The QSM excreted by C. albicans is farnesol (C(15)H(26)O; molecular weight, 222.37). QSM is extracellular, and is produced continuously during growth and over a temperature range from 23 to 43 degrees C, in amounts roughly proportional to the CFU/milliliter. Production is not dependent on the type of carbon source nor nitrogen source or on the chemical nature of the growth medium. Both commercial mixed isomer and (E,E)-farnesol exhibited QSM activity (the ability to prevent GTF) at a level sufficient to account for all the QSM activity present in C. albicans supernatants, i.e., 50% GTF at ca. 30 to 35 microM. Nerolidol was ca. two times less active than farnesol. Neither geraniol (C(10)), geranylgeraniol (C(20)), nor farnesyl pyrophosphate had any QSM activity.
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“In the biofilm environment, Candida species cells have the ability to communicate with each other via quorum sensing (via numerous signalling molecules), which is directly dependent on the cell density [148].”
From Candida glabrata Biofilms: How Far Have We Come? (2017) · cites this paper as [148]
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Metadata
- Authors
- Hornby, J. M., Jensen, E. C., Lisec, A. D., Tasto, J. J., Jahnke, B., Shoemaker, R., Dussault, P., & Nickerson, K. W.
- Affiliations
- University of Nebraska–Lincoln (US)
- College of Saint Benedict and Saint John's University (US)
- Venue
- Applied and Environmental Microbiology
- Publisher
- American Society for Microbiology
- Published
- 2001-07
- Volume
- 67
- Issue
- 7
- Pages
- 2982-2992
- ISSN
- 0099-2240 (ISSN-L)
- 1098-5336
- PMC
- PMC92970
- OpenAlex
- W2144677145
- Cited by
- 983
- References
- 33
- Citations by year
- 2026: 23 · 2025: 30 · 2024: 32 · 2023: 51 · 2022: 42 · 2021: 59 · 2020: 46 · 2019: 48 · 2018: 42 · 2017: 60 · 2016: 40 · 2015: 51 · 2014: 45 · 2013: 42 · 2012: 50
- FWCI
- 10.29
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Applied and Environmental Microbiology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Lincoln (University of Nebraska) (submittedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Keywords
- quorum sensing, Candida albicans, farnesol, dimorphic fungi, germ tube formation, mycelial development, extracellular signaling molecules, inoculum size effect, nerolidol, geranylgeraniol, geraniol, farnesyl pyrophosphate
- MeSH terms
- Candida albicans, Chromatography, High Pressure Liquid, Chromatography, Thin Layer, Culture Media, Farnesol, Hot Temperature, Gas Chromatography-Mass Spectrometry, Gene Expression Regulation, Fungal
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