The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
Isolation and Characterization of Novel Marine-Derived Actinomycete Taxa Rich in Bioactive Metabolites
Open accessAbstract
A unique selective enrichment procedure has resulted in the isolation and identification of two new genera of marine-derived actinobacteria. Approximately 90% of the microorganisms cultured by using the presented method were from the prospective new genera, a result indicative of its high selectivity. In this study, 102 actinomycetes were isolated from subtidal marine sediments collected from the Bismarck Sea and the Solomon Sea off the coast of Papua New Guinea. A combination of physiological parameters, chemotaxonomic characteristics, distinguishing 16S rRNA gene sequences, and phylogenetic analysis based on 16S rRNA genes provided strong evidence for the two new genera (represented by strains of the PNG1 clade and strain UMM518) within the family Micromonosporaceae . Biological activity testing of fermentation products from the new marine-derived actinomycetes revealed that several had activities against multidrug-resistant gram-positive pathogens, malignant cells, and vaccinia virus replication.
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Cited by
Discovery of novel metabolites from marine actinomycetes
Lam, K. S. (2006) · Current Opinion in Microbiology · doi:10.1016/j.mib.2006.03.004 · Cited by 539
New drugs from marine microbes: The tide is turning
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Metadata
- Authors
- Magarvey, N. A., Keller, J. M., Bernan, V., Dworkin, M., & Sherman, D. H.
- Venue
- Applied and Environmental Microbiology
- Publisher
- American Society for Microbiology
- Published
- 2004-12
- Volume
- 70
- Issue
- 12
- Pages
- 7520-7529
- ISSN
- 0099-2240 (ISSN-L)
- 1098-5336
- OpenAlex
- W1970935314
- Cited by
- 274
- References
- 27
- FWCI
- 4.89
- Type
- journal article
- Language
- en
- Open access
- green
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- Magarvey, N. A., Keller, J. M., Bernan, V., Dworkin, M., & Sherman, D. H. (2004). Isolation and Characterization of Novel Marine-Derived Actinomycete Taxa Rich in Bioactive Metabolites. Applied and Environmental Microbiology. https://doi.org/10.1128/aem.70.12.7520-7529.2004
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.