New drugs from marine microbes: The tide is turning
Open accessAbstract
This is a mini-review demonstrating that investigation of the genomics of marine microbes from all three domains has the potential to revolutionize the search for secondary metabolites originally thought to be the product of marine invertebrates. The basis for the review was a symposium at the 2005 Annual Meeting of the SIM covering some aspects of the potential for marine microbes to be the primary producers of such metabolites. The work reported at that symposium has been integrated into a fuller discussion of current published literature on the subject with examples drawn from bacteria, cyanophytes and fungi.
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Marine-derived fungi represent a rich and promising source of novel anticancer agents.
“Marine-derived fungi represent a rich and promising source of novel anticancer agents [135,136].”
From Marine Natural Products: A Source of Novel Anticancer Drugs (2019) · cites this paper as [135]
The Commentary (page not provided) suggests that marine-sourced Aspergillus fungi may yield surprising secondary metabolites, supporting their promise as a source of new compounds. It does not identify fungi as a rich source of anticancer agents; the cancer-directed discoveries discussed in the Marine actinomycetes section concern bacteria. (LLM, conf=0.83)
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Marine Natural Products: A Source of Novel Anticancer Drugs
Khalifa, S. A. M., Elias, N., Farag, M. A., Chen, L., Saeed, A., Hegazy, M.-E. F., Moustafa, M. S., Abd El-Wahed, A., Al-Mousawi, S. M., Musharraf, S. G., et al. (2019) · Marine Drugs · doi:10.3390/md17090491 · Cited by 555 · see citing works
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- Authors
- Newman, D. J., & Hill, R. T.
- Affiliations
- Frederick National Laboratory for Cancer Research (US)
- University of Maryland, Baltimore (US)
- Corresponding author
- Newman, David J.
- Hill, Russell T.
- Venue
- Journal of Industrial Microbiology & Biotechnology
- Publisher
- Oxford University Press (OUP)
- Published
- 2006-04-06
- Volume
- 33
- Issue
- 7
- Pages
- 539-544
- ISSN
- 1367-5435 (ISSN-L)
- 1476-5535
- OpenAlex
- W1969579284
- Cited by
- 144
- References
- 34
- Citations by year
- 2025: 1 · 2024: 3 · 2023: 3 · 2022: 9 · 2021: 7 · 2020: 6 · 2019: 7 · 2018: 8 · 2017: 6 · 2016: 7 · 2015: 3 · 2014: 13 · 2013: 11 · 2012: 8
- FWCI
- 6.68
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Journal of Industrial Microbiology & Biotechnology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Science Foundation (0238515)
- Topics
- Health Sciences › Medicine › Pharmacology › Microbial Natural Products and Biosynthesis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Marine Sponges and Natural Products
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Microbial Metabolism and Applications
- Keywords
- marine microorganisms, secondary metabolites, marine natural products, microbial genomics, marine bacteria, cyanobacteria, marine fungi, marine invertebrates, drug discovery
- MeSH terms
- Animals, Pharmaceutical Preparations, Marine Biology, Urochordata, Genome, Anthozoa, Actinobacteria
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