Cited by 144Microbial Natural Products and BiosynthesisMarine Sponges and Natural ProductsMicrobial Metabolism and Applications

New drugs from marine microbes: The tide is turning

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Newman, David J., Hill, Russell T.·2006·Journal of Industrial Microbiology & Biotechnology

Abstract

This is a mini-review demonstrating that investigation of the genomics of marine microbes from all three domains has the potential to revolutionize the search for secondary metabolites originally thought to be the product of marine invertebrates. The basis for the review was a symposium at the 2005 Annual Meeting of the SIM covering some aspects of the potential for marine microbes to be the primary producers of such metabolites. The work reported at that symposium has been integrated into a fuller discussion of current published literature on the subject with examples drawn from bacteria, cyanophytes and fungi.

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Crossref · 10.1007/s10295-006-0115-2

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  • Marine-derived fungi represent a rich and promising source of novel anticancer agents.

    “Marine-derived fungi represent a rich and promising source of novel anticancer agents [135,136].”

    From Marine Natural Products: A Source of Novel Anticancer Drugs (2019) · cites this paper as [135]

    The Commentary (page not provided) suggests that marine-sourced Aspergillus fungi may yield surprising secondary metabolites, supporting their promise as a source of new compounds. It does not identify fungi as a rich source of anticancer agents; the cancer-directed discoveries discussed in the Marine actinomycetes section concern bacteria. (LLM, conf=0.83)

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Authors
Newman, D. J., & Hill, R. T.
Affiliations
  • Frederick National Laboratory for Cancer Research (US)
  • University of Maryland, Baltimore (US)
Corresponding author
  • Newman, David J.
  • Hill, Russell T.
Venue
Journal of Industrial Microbiology & Biotechnology
Published
2006-04-06
Volume
33
Issue
7
Pages
539-544
ISSN
  • 1367-5435 (ISSN-L)
  • 1476-5535
OpenAlex
W1969579284
Cited by
144
References
34
Citations by year
2025: 1 · 2024: 3 · 2023: 3 · 2022: 9 · 2021: 7 · 2020: 6 · 2019: 7 · 2018: 8 · 2017: 6 · 2016: 7 · 2015: 3 · 2014: 13 · 2013: 11 · 2012: 8
FWCI
6.68
Type
journal article
Language
en
Open access
Locations
  • Journal of Industrial Microbiology & Biotechnology (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Science Foundation (0238515)
Topics
  • Health Sciences › Medicine › Pharmacology › Microbial Natural Products and Biosynthesis
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Marine Sponges and Natural Products
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Microbial Metabolism and Applications
Keywords
marine microorganisms, secondary metabolites, marine natural products, microbial genomics, marine bacteria, cyanobacteria, marine fungi, marine invertebrates, drug discovery
MeSH terms
Animals, Pharmaceutical Preparations, Marine Biology, Urochordata, Genome, Anthozoa, Actinobacteria

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