The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Overexpression of the 14α-Demethylase Target Gene ( CYP51 ) Mediates Fungicide Resistance in Blumeriella jaapii
Open accessAbstract
Sterol demethylation inhibitor (DMI) fungicides are widely used to control fungi pathogenic to humans and plants. Resistance to DMIs is mediated either through alterations in the structure of the target enzyme CYP51 (encoding 14α-demethylase), through increased expression of the CYP51 gene, or through increased expression of efflux pumps. We found that CYP51 expression in DMI-resistant (DMI R ) isolates of the cherry leaf spot pathogen Blumeriella jaapii was increased 5- to 12-fold compared to that in DMI-sensitive (DMI S ) isolates. Analysis of sequences upstream of CYP51 in 59 DMI R isolates revealed that various forms of a truncated non-long terminal direct repeat long interspersed nuclear element retrotransposon were present in all instances. Similar inserts upstream of CYP51 were not present in any of 22 DMI S isolates examined.
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Cites
Evolution of antifungal-drug resistance: mechanisms and pathogen fitness
Anderson, J. B. (2005) · Nature Reviews Microbiology · doi:10.1038/nrmicro1179 · Cited by 375
Mellado, E., Diaz-Guerra, T. M., Cuenca-Estrella, M., & Rodriguez-Tudela, J. L. (2001) · Journal of Clinical Microbiology · doi:10.1128/jcm.39.7.2431-2438.2001 · Cited by 307
Cited by
Azole resistance in Aspergillus fumigatus: a side-effect of environmental fungicide use?
Verweij, P. E., Snelders, E., Kema, G. H., Mellado, E., & Melchers, W. J. (2009) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(09)70265-8 · Cited by 604
Mellado, E., Garcia-Effron, G., Alcázar-Fuoli, L., Melchers, W. J. G., Verweij, P. E., Cuenca-Estrella, M., & Rodríguez-Tudela, J. L. (2007) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01092-06 · Cited by 490
Koch, A., Kumar, N., Weber, L., Keller, H., Imani, J., & Kogel, K.-H. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1306373110 · Cited by 431
Azole fungicides – understanding resistance mechanisms in agricultural fungal pathogens
Price, C. L., Parker, J. E., Warrilow, A. G., Kelly, D. E., & Kelly, S. L. (2015) · Pest Management Science · doi:10.1002/ps.4029 · Cited by 321
Constraints on the evolution of azole resistance in plant pathogenic fungi.
Cools, H. J., Hawkins, N. J., & Fraaije, B. A. (2013) · Plant Pathology · doi:10.1111/ppa.12128 · Cited by 163
Metadata
- Authors
- Ma, Z., Proffer, T. J., Jacobs, J. L., & Sundin, G. W.
- Venue
- Applied and Environmental Microbiology
- Publisher
- American Society for Microbiology
- Published
- 2006-04
- Volume
- 72
- Issue
- 4
- Pages
- 2581-2585
- ISSN
- 0099-2240 (ISSN-L)
- 1098-5336
- OpenAlex
- W2132960741
- Cited by
- 183
- References
- 2
- FWCI
- 8.09
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Overexpression of the 14α-Demethylase Target Gene ( CYP51 ) Mediates Fungicide Resistance in Blumeriella jaapii. https://app.cochat.ai/papers/10.1128/aem.72.4.2581-2585.2006
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- Ma, Z., Proffer, T. J., Jacobs, J. L., & Sundin, G. W. (2006). Overexpression of the 14α-Demethylase Target Gene ( CYP51 ) Mediates Fungicide Resistance in Blumeriella jaapii. Applied and Environmental Microbiology. https://doi.org/10.1128/aem.72.4.2581-2585.2006
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