The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.
Host-induced gene silencing of cytochrome P450 lanosterol C14α-demethylase–encoding genes confers strong resistance to Fusarium species
Open accessAbstract
Significance: We demonstrate that host-induced gene silencing (HIGS) targeting the fungal sterol 14α-demethylase ( CYP51 ) genes restricts Fusarium infection in plants. Fusarium diseases have a significant impact not only on global grain production, but also on food safety because of grain contamination with mycotoxins. We capitalized on the knowledge that demethylation inhibitor fungicides target cytochrome P450 lanosterol C-14α-demethylase. In Fusarium graminearum ( Fg ), this enzyme is encoded by three paralogous genes. Transgenic Arabidopsis and barley expressing a double-stranded RNA targeting all three CYP51 genes exhibited complete immunity to Fg . Our results provide proof-of-concept that HIGS of the CYP51 genes is an effective strategy for controlling Fusarium , demonstrating that HIGS is a powerful tool, which could revolutionize crop plant protection.
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Cites
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Induced Systemic Resistance for Improving Plant Immunity by Beneficial Microbes
Yu, Y., Gui, Y., Li, Z., Jiang, C., Guo, J., & Niu, D. (2022) · Plants · doi:10.3390/plants11030386 · Cited by 570
The cytochrome P450 superfamily: Key players in plant development and defense
XU, J., WANG, X.-Y., & GUO, W.-Z. (2015) · Journal of Integrative Agriculture · doi:10.1016/s2095-3119(14)60980-1 · Cited by 355
Fungicide resistance management: Maximizing the effective life of plant protection products
Corkley, I., Fraaije, B., & Hawkins, N. (2022) · Plant Pathology · doi:10.1111/ppa.13467 · Cited by 280
Fungicide Resistance: Progress in Understanding Mechanism, Monitoring, and Management
Yin, Y., Miao, J., Shao, W., Liu, X., Zhao, Y., & Ma, Z. (2023) · Phytopathology® · doi:10.1094/phyto-10-22-0370-kd · Cited by 279
Control of postharvest fungal diseases in fruits using external application of RNAi
de Oliveira Filho, J. G., Silva, G. D. C., Cipriano, L., Gomes, M., & Egea, M. B. (2021) · Journal of Food Science · doi:10.1111/1750-3841.15816 · Cited by 37
Metadata
- Authors
- Koch, A., Kumar, N., Weber, L., Keller, H., Imani, J., & Kogel, K.-H.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2013-11-11
- Volume
- 110
- Issue
- 48
- Pages
- 19324-19329
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1987357838
- Cited by
- 431
- References
- 48
- FWCI
- 13.57
- Type
- journal article
- Language
- en
- Open access
- green
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- Koch, A., Kumar, N., Weber, L., Keller, H., Imani, J., & Kogel, K.-H. (2013). Host-induced gene silencing of cytochrome P450 lanosterol C14α-demethylase–encoding genes confers strong resistance to Fusarium species. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1306373110
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
