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Cited by 71Malaria Research and ControlChemokine receptors and signalingPreterm Birth and Chorioamnionitis

Levels of Macrophage Inflammatory Protein 1α (MIP-1α) and MIP-1β in Intervillous Blood Plasma Samples from Women with Placental Malaria and Human Immunodeficiency Virus Infection

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Chaisavaneeyakorn, Sujittra, Moore, Julie M., Mirel, Lisa, Othoro, Caroline, Otieno, Juliana, Chaiyaroj, Sansanee C., Shi, Ya Ping, Nahlen, Bernard L. +2 more·2003·Clinical and Vaccine Immunology
DOI 10.1128/cdli.10.4.631-636.2003PMC PMC164254
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Abstract

Macrophage inflammatory protein-1α (MIP-1α) and MIP-1β play an important role in modulating immune responses. To understand their importance in immunity to placental malaria (PM) and in human immunodeficiency virus (HIV)-PM coinfection, we investigated levels of these chemokines in the placental intervillous blood plasma (IVB plasma) and cord blood plasma of HIV-negative PM-negative, HIV-negative PM-positive, HIV-positive PM-negative, and HIV-positive PM-positive women. Compared to HIV-negative PM-negative women, the MIP-1β concentration in IVB plasma was significantly elevated in HIV-negative PM-positive women and HIV-positive PM-positive women, but it was unaltered in HIV-positive PM-negative women. Also, PM-infected women, irrespective of their HIV status, had significantly higher levels of MIP-1β than HIV-positive PM-negative women. The MIP-1α level was not altered in association with either infection. The IVB plasma levels of MIP-1α and MIP-1β positively correlated with the cord blood plasma levels of these chemokines. As with IVB plasma, only cord plasma from PM-infected mothers had significantly elevated levels of MIP-1β compared to PM-negative mothers, irrespective of their HIV infection status. MIP-1β and MIP-1α levels in PM-positive women were positively associated with parasite density and malaria pigment levels. Regardless of HIV serostatus, the IVB MIP-1β level was significantly lower in women with PM-associated anemia. In summary, an elevated level of MIP-1β was associated with PM. HIV infection did not significantly alter these two chemokine levels in IVB plasma.

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Crossref · 10.1128/cdli.10.4.631-636.2003

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  • PM is associated with inflammatory immune responses, with increased levels of soluble mediators like TNF-α, TNF receptor I, TNF receptor II and IL-10 in peripheral blood.

    “PM is associated with inflammatory immune responses [75–79], with increased levels of soluble mediators like TNF-α, TNF receptor I, TNF receptor II and IL-10 in peripheral blood [80,81].”

    From Diagnosing malaria in pregnancy: An update (2012) · cites this paper as [78]

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Authors
Chaisavaneeyakorn, S., Moore, J. M., Mirel, L., Othoro, C., Otieno, J., Chaiyaroj, S. C., Shi, Y. P., Nahlen, B. L., Lal, A. A., & Udhayakumar, V.
Affiliations
Centers for Disease Control and Prevention (US)
ORCID
Venue
Clinical and Vaccine Immunology
Publisher
American Society for Microbiology
Published
2003-07
Volume
10
Issue
4
Pages
631-636
ISSN
  • 1556-679X (ISSN-L)
  • 1556-6811
DOI
10.1128/cdli.10.4.631-636.2003
PMC
PMC164254
OpenAlex
W2147783813
Cited by
71
References
25
Citations by year
2025: 2 · 2024: 3 · 2023: 4 · 2022: 1 · 2021: 2 · 2020: 5 · 2019: 5 · 2017: 3 · 2016: 1 · 2015: 1 · 2013: 8 · 2012: 9
FWCI
4.74
Type
journal article
Language
en
Open access
Licence
journals.asm.org/non-commercial-tdm-license (tdm)
Locations
  • Clinical and Vaccine Immunology (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • United States Agency for International Development
  • World Health Organization
  • Mahidol University
  • National Institutes of Health
  • Centers for Disease Control and Prevention
  • National Institute of Allergy and Infectious Diseases (R01AI050240, AI50240)
Topics
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Malaria Research and Control
  • Health Sciences › Medicine › Oncology › Chemokine receptors and signaling
  • Health Sciences › Medicine › Epidemiology › Preterm Birth and Chorioamnionitis
Keywords
macrophage inflammatory protein-1alpha, MIP-1β, chemokines, placental malaria, HIV coinfection, cord plasma, malaria parasite density, hemozoin, anemia
MeSH terms
Adult, Disease Susceptibility, Female, Fetal Blood, Gene Expression Regulation, Hemeproteins, Humans, Kenya, Malaria, Placenta Diseases, Plasma, Pregnancy, Pregnancy Complications, Infectious, Retrospective Studies, Cohort Studies, HIV Infections, Th1 Cells, Macrophage Inflammatory Proteins, Chemokine CCL3, Chemokine CCL4

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