Immunologic activation of human syncytiotrophoblast by Plasmodium falciparum

Lucchi, Naomi W; Peterson, David S; Moore, Julie M

doi:10.1186/1475-2875-7-42

Cited by 58Malaria Research and ControlReproductive System and PregnancyPregnancy and preeclampsia studies

Immunologic activation of human syncytiotrophoblast by Plasmodium falciparum

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Lucchi, Naomi W, Peterson, David S, Moore, Julie M·2008·Malaria Journal

DOI 10.1186/1475-2875-7-42PMC PMC2268702

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Abstract

Background: Malaria during pregnancy is characterized by the sequestration of malaria-infected red blood cells (iRBC) in the intervillous spaces of the placenta, often accompanied by the infiltration of maternal mononuclear cells, causing substantial maternal and foetal/infant morbidity. The iRBC bind to receptors expressed by the syncytiotrophoblast (ST). How ST responds to this interaction remains poorly understood. Because it is known that ST is immunoactive and can respond to infectious agents, the consequences of this ST-iRBC interaction should be investigated. Methods: An in vitro system was used to assess the biochemical and immunological changes induced in ST by ST-adherent iRBCs. Changes in ST mitogen-activated protein kinase (MAPK) activation were assessed by immunoblotting and mRNA expression levels of selected cytokine and chemokines in primary ST bound by iRBC were determined using real-time, reverse transcription PCR. In addition, secreted cytokine and chemokine proteins were assayed by standard ELISA, and chemotaxis of PBMC was assessed using a two-chamber assay system. Results: Following iRBC/ST interaction, ST C-Jun N-terminal kinase 1 (JNK1) was activated and modest increases in the mRNA expression of TGF-β and IL-8/CXCL8 were observed. In addition, this interaction increased secretion of MIF and MIP-1α/CCL3 by ST and induced migration of PBMC towards iRBC-stimulated ST. Conclusion: Results from this study provide the first evidence that ST participates in shaping the local immunological milieu and in the recruitment of maternal immune cells to the maternal blood space during placental malaria infection.

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Some studies concluded that complications during pregnancy and foetal death in P. falciparum placental malaria might be determined by changes in the regulation of apoptosis via Fas/FasL and increased Th1 immune responses in the syncytiotrophoblast.
“Some studies concluded that complications during pregnancy and foetal death observed in P. falciparum placental malaria might be determined by changes in the regulation of apoptosis, via Fas /FasL [9], and increased Th1 immune responses in the syncytiotrophoblast [10,11].”
From Submicroscopic infection of placenta by Plasmodium produces Th1/Th2 cytokine imbalance, inflammation and hypoxia in women from north-west Colombia (2014) · cites this paper as [11]

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Authors: Lucchi, N. W., Peterson, D. S., & Moore, J. M.
Affiliations: Centers for Disease Control and Prevention (US)
University of Georgia (US)
Corresponding author: Moore, Julie M
ORCID: Lucchi, Naomi W
Peterson, David S
Moore, Julie M
Venue: Malaria Journal
Publisher: Springer Science and Business Media LLC
Published: 2008-02-29
Volume: 7
Issue: 1
Pages: 42-42
ISSN: 1475-2875 (ISSN-L)
DOI: 10.1186/1475-2875-7-42
PMC: PMC2268702
OpenAlex: W2081023512
Cited by: 58
References: 54
Citations by year: 2026: 2 · 2025: 2 · 2023: 2 · 2022: 2 · 2021: 3 · 2020: 2 · 2019: 3 · 2018: 3 · 2017: 3 · 2016: 2 · 2015: 8 · 2014: 4 · 2013: 6 · 2012: 5
FWCI: 3.64
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
Locations: Malaria Journal (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders: University of Georgia
National Institutes of Health
University of Georgia Research Foundation
National Institute of Allergy and Infectious Diseases (R01AI050240)
Topics: Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Malaria Research and Control
Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
Keywords: syncytiotrophoblast, Plasmodium falciparum, placental malaria, malaria in pregnancy, MAPK signaling, cytokine and chemokine expression, TGF-beta, IL-8/CXCL8, macrophage migration inhibitory factor, placental immunity
MeSH terms: Animals, Cell Adhesion, Cell Line, Chemotaxis, Leukocyte, Erythrocytes, Female, Humans, Placenta, Plasmodium falciparum, RNA, Messenger, Trophoblasts, Blotting, Western, Gene Expression, Cytokines, Coculture Techniques, Cell Culture Techniques, Reverse Transcriptase Polymerase Chain Reaction, Mitogen-Activated Protein Kinase 8, Cell Migration Assays

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Immunologic activation of human syncytiotrophoblast by Plasmodium falciparum

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