The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Acute Inflammatory Response to Endotoxin in Mice and Humans
Open accessAbstract
Endotoxin injection has been widely used to study the acute inflammatory response. In this study, we directly compared the inflammatory responses to endotoxin in mice and humans.Escherichia coli type O113 endotoxin was prepared under identical conditions, verified to be of equal biological potency, and used for both mice and humans. The dose of endotoxin needed to induce an interleukin-6 (IL-6) concentration in plasma of ∼1,000 pg/ml 2 h after injection was 2 ng/kg of body weight in humans and 500 ng/kg in mice. Healthy adult volunteers were injected intravenously with endotoxin, and male C57BL/6 mice (n= 4 to 12) were injected intraperitoneally with endotoxin. Physiological, hematological, and cytokine responses were determined. Endotoxin induced a rapid physiological response in humans (fever, tachycardia, and slight hypotension) but not in mice. Both mice and humans exhibited lymphopenia with a nadir at 4 h and recovery by 24 h. The levels of tumor necrosis factor (TNF) and IL-6 in plasma peaked at 2 h and returned to baseline levels by 4 to 6 h. IL-1 receptor antagonist RA and TNF soluble receptor I were upregulated in both mice and humans but were upregulated more strongly in humans. Mice produced greater levels of CXC chemokines, and both mice and humans exhibited peak production at 2 h. These studies demonstrate that although differences exist and a higher endotoxin challenge is necessary in mice, there are several similarities in the inflammatory response to endotoxin in mice and humans.
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Cites
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Of Mice and Not Men: Differences between Mouse and Human Immunology
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Glucocorticoid therapy alters hormonal and cytokine responses to endotoxin in man
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“Similar findings have been reported in numerous studies in humans and mice (1, 2, 5, 17, 18, 24, 26, 31, 34, 35).”
ResultSelf-citationMartich, G. D., Boujoukos, A. J., & Suffredini, A. F. (1993) · Immunobiology · doi:10.1016/s0171-2985(11)80353-0 · Cited by 275
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Seok, J., Warren, H. S., Cuenca, A. G., Mindrinos, M. N., Baker, H. V., Xu, W., Richards, D. R., McDonald-Smith, G. P., Gao, H., Hennessy, L., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1222878110 · Cited by 3,005
Self-citationIL-1 and IL-1ra are key regulators of the inflammatory response to RNA vaccines
Tahtinen, S., Tong, A.-J., Himmels, P., Oh, J., Paler-Martinez, A., Kim, L., Wichner, S., Oei, Y., McCarron, M. J., Freund, E. C., et al. (2022) · Nature Immunology · doi:10.1038/s41590-022-01160-y · Cited by 535
Immunotoxicity of Perfluorinated Compounds: Recent Developments
DeWitt, J. C., Peden-Adams, M. M., Keller, J. M., & Germolec, D. R. (2012) · Toxicologic Pathology · doi:10.1177/0192623311428473 · Cited by 457
Schroder, K., Irvine, K. M., Taylor, M. S., Bokil, N. J., Le Cao, K.-A., Masterman, K.-A., Labzin, L. I., Semple, C. A., Kapetanovic, R., Fairbairn, L., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1110156109 · Cited by 308
Probiotic-guided CAR-T cells for solid tumor targeting
Vincent, R. L., Gurbatri, C. R., Li, F., Vardoshvili, A., Coker, C., Im, J., Ballister, E. R., Rouanne, M., Savage, T., de los Santos-Alexis, K., et al. (2023) · Science · doi:10.1126/science.add7034 · Cited by 273
Metadata
- Authors
- Copeland, S., Warren, H. S., Lowry, S. F., Calvano, S. E., & Remick, D.
- Venue
- Clinical and Vaccine Immunology
- Publisher
- American Society for Microbiology
- Published
- 2005-01
- Volume
- 12
- Issue
- 1
- Pages
- 60-67
- ISSN
- 1556-679X (ISSN-L)
- 1556-6811
- OpenAlex
- W2145343991
- Cited by
- 436
- References
- 5
- FWCI
- 2.47
- Type
- journal article
- Language
- en
- Open access
- diamond
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- Copeland, S., Warren, H. S., Lowry, S. F., Calvano, S. E., & Remick, D. (2005). Acute Inflammatory Response to Endotoxin in Mice and Humans. Clinical and Vaccine Immunology. https://doi.org/10.1128/cdli.12.1.60-67.2005
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
