Cited by 506Bacterial Infections and VaccinesPneumonia and Respiratory InfectionsStreptococcal Infections and Treatments

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Pathogenesis and Pathophysiology of Pneumococcal Meningitis

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Mook-Kanamori, Barry B., Geldhoff, Madelijn, van der Poll, Tom, van de Beek, Diederik·2011·Clinical Microbiology Reviews

DOI 10.1128/cmr.00008-11PMC PMC3131058

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Abstract

Pneumococcal meningitis continues to be associated with high rates of mortality and long-term neurological sequelae. The most common route of infection starts by nasopharyngeal colonization by Streptococcus pneumoniae, which must avoid mucosal entrapment and evade the host immune system after local activation. During invasive disease, pneumococcal epithelial adhesion is followed by bloodstream invasion and activation of the complement and coagulation systems. The release of inflammatory mediators facilitates pneumococcal crossing of the blood-brain barrier into the brain, where the bacteria multiply freely and trigger activation of circulating antigen-presenting cells and resident microglial cells. The resulting massive inflammation leads to further neutrophil recruitment and inflammation, resulting in the well-known features of bacterial meningitis, including cerebrospinal fluid pleocytosis, cochlear damage, cerebral edema, hydrocephalus, and cerebrovascular complications. Experimental animal models continue to further our understanding of the pathophysiology of pneumococcal meningitis and provide the platform for the development of new adjuvant treatments and antimicrobial therapy. This review discusses the most recent views on the pathophysiology of pneumococcal meningitis, as well as potential targets for (adjunctive) therapy.

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A Toll-like receptor recognizes bacterial DNA
Hemmi, H., Takeuchi, O., Kawai, T., Kaisho, T., Sato, S., Sanjo, H., Matsumoto, M., Hoshino, K., Wagner, H., Takeda, K., et al. (2000) · Nature · doi:10.1038/35047123 · Cited by 6,491 · cited 8×
“Additionally, S. pneumoniae is naturally able to integrate DNA from killed and closely related pathogens into its own genome, thus gaining a competitive advantage (305).”
BackgroundInfluential
Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo
Nimmerjahn, A., Kirchhoff, F., & Helmchen, F. (2005) · Science · doi:10.1126/science.1110647 · Cited by 5,827
The phosphoinositide 3-kinase pathway
Cantley, L. C. (2002) · Science · doi:10.1126/science.296.5573.1655 · Cited by 5,621
Immunobiology: the immune system in health and disease
(1995) · Choice Reviews Online · doi:10.5860/choice.32-3876 · Cited by 4,111
Interleukin 10(IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes.
de Waal Malefyt, R., Abrams, J., Bennett, B., Figdor, C. G., & de Vries, J. E. (1991) · The Journal of experimental medicine · doi:10.1084/jem.174.5.1209 · Cited by 3,762
Defining the normal bacterial flora of the oral cavity
Aas, J. A., Paster, B. J., Stokes, L. N., Olsen, I., & Dewhirst, F. E. (2005) · Journal of Clinical Microbiology · doi:10.1128/jcm.43.11.5721-5732.2005 · Cited by 3,092
Leukocyte-endothelial adhesion molecules
Carlos, T., & Harlan, J. (1994) · Blood · doi:10.1182/blood.v84.7.2068.bloodjournal8472068 · Cited by 2,687
Antitumor Activity of Thalidomide in Refractory Multiple Myeloma
Singhal, S., Mehta, J., Desikan, R., Ayers, D., Roberson, P., Eddlemon, P., Munshi, N., Anaissie, E., Wilson, C., Dhodapkar, M., et al. (1999) · New England Journal of Medicine · doi:10.1056/nejm199911183412102 · Cited by 2,575
LPS induction of gene expression in human monocytes
Guha, M., & Mackman, N. (2001) · Cellular Signalling · doi:10.1016/s0898-6568(00)00149-2 · Cited by 2,333
Practice Guidelines for the Management of Bacterial Meningitis
Tunkel, A. R., Hartman, B. J., Kaplan, S. L., Kaufman, B. A., Roos, K. L., Scheld, W. M., & Whitley, R. J. (2004) · Clinical Infectious Diseases · doi:10.1086/425368 · Cited by 2,308

Show all 569 references

Research works printed but not linked: 2

10.1182/blood.v84.7.2068.2068 · DOI
Mestecky J. . 2005. Mucosal immunology, 3rd ed. Elsevier Academic Press, Amsterdam, Netherlands.

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Prager, O., Friedman, A., & Nebenzahl, Y. M. (2017) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2017.4082 · Cited by 22
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Ricci, S., Gerlini, A., Pammolli, A., Chiavolini, D., Braione, V., Tripodi, S. A., Colombari, B., Blasi, E., Oggioni, M. R., Peppoloni, S., et al. (2013) · BMC Infectious Diseases · doi:10.1186/1471-2334-13-444 · Cited by 21
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Zhang, D., Zhao, S., Zhang, Z., Xu, D., Lian, D., Wu, J., He, D., Sun, K., & Li, L. (2021) · Journal of Neuroinflammation · doi:10.1186/s12974-021-02294-w · Cited by 20
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Parthasarathy, G., & Philipp, M. T. (2012) · Frontiers in Immunology · doi:10.3389/fimmu.2012.00306 · Cited by 20
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Yau, B., Mitchell, A. J., Too, L. K., Ball, H. J., & Hunt, N. H. (2015) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2015.0078 · Cited by 19
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Khan, N., & Jan, A. T. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.00742 · Cited by 19
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Muri, L., Oberhänsli, S., Buri, M. C., Le, N. D., Grandgirard, D., Bruggmann, R., Müri, R. M., & Leib, S. L. (2020) · PLoS ONE · doi:10.1371/journal.pone.0232863 · Cited by 19
Thrombin‐activatable fibrinolysis inhibitor influences disease severity in humans and mice with pneumococcal meningitis
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Self-citation
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Gowin, E., Wysocki, J., Avonts, D., Januszkiewicz‐Lewandowska, D., & Michalak, M. (2016) · Archives of Medical Science · doi:10.5114/aoms.2016.59269 · Cited by 19
Quantitative Proteomics of Cerebrospinal Fluid in Paediatric Pneumococcal Meningitis
Gómez‐Baena, G., Bennett, R. J., Martínez-Rodríguez, C., Wnęk, M., Laing, G. D., Hickey, G. L., McLean, L., Beynon, R. J., & Carrol, E. D. (2017) · Scientific Reports · doi:10.1038/s41598-017-07127-6 · Cited by 19
A pathogen‐derived metabolite induces microglial activation via odorant receptors
Lee, N., Jae, Y., Kim, M., Cho, T., Lee, C., Hong, Y. R., Hyeon, D. Y., Ahn, S. H., Kwon, H., Kim, K., et al. (2020) · FEBS Journal · doi:10.1111/febs.15234 · Cited by 19
Evolving concepts in pediatric bacterial meningitis—Part I: Pathophysiology and diagnosis
Lipton, J. D., & Schafermeyer, R. W. (1993) · Annals of Emergency Medicine · doi:10.1016/s0196-0644(05)81268-5 · Cited by 19
Understanding Host Immunity and the Gut Microbiota Inspires the New Development of Vaccines and Adjuvants
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Single-cell transcriptome reveals highly complement activated microglia cells in association with pediatric tuberculous meningitis
Mo, S., Shi, C., Cai, Y., Xu, M., Xu, H., Xu, Y., Zhang, K., Zhang, Y., Liu, J., Che, S., et al. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1387808 · Cited by 18
Fulminant Bacterial Meningitis
Radetsky, M. (2014) · The Pediatric Infectious Disease Journal · doi:10.1097/01.inf.0000435508.67490.f0 · Cited by 18
Double deficiency of toll-like receptors 2 and 4 alters long-term neurological sequelae in mice cured of pneumococcal meningitis
Too, L. K., Yau, B., Baxter, A. G., McGregor, I. S., & Hunt, N. H. (2019) · Scientific Reports · doi:10.1038/s41598-019-52212-7 · Cited by 18
Transcranial Doppler Ultrasonographic Evaluation of Cerebrovascular Abnormalities in Children With Acute Bacterial Meningitis
Fonseca, Y., Tshimanga, T., Ray, S., Malhotra, H., Mbaka, J. P., Mabiala, J. B., Gushu, M. B., Phiri, T., Chikaonda, B. M., Musungufu, D. A., et al. (2021) · Frontiers in Neurology · doi:10.3389/fneur.2020.558857 · Cited by 18
Microglia activated by microbial neuraminidase contributes to ependymal cell death
Fernández‐Arjona, M. D. M., León‐Rodríguez, A., López-Ávalos, M. D., & Grondona, J. M. (2021) · Fluids and Barriers of the CNS · doi:10.1186/s12987-021-00249-0 · Cited by 18
Receptor Blockade: A Novel Approach to Protect the Brain From Pneumococcal Invasion
Iovino, F., Thorsdottir, S., & Henriques‐Normark, B. (2018) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiy193 · Cited by 18

Authors: Mook-Kanamori, B. B., Geldhoff, M., van der Poll, T., & van de Beek, D.
Affiliations: Amsterdam UMC Location University of Amsterdam (NL)
Department of Neurology and Center for Experimental and Molecular Medicine (CEMM), Center of Infection and Immunity Amsterdam (CINIMA), Academic Medical Center, P.O. Box 22660, 1100DD Amsterdam, The Netherlands
Venue: Clinical Microbiology Reviews
Publisher: American Society for Microbiology
Published: 2011-07
Volume: 24
Issue: 3
Pages: 557-591
ISSN: 0893-8512 (ISSN-L)
1098-6618
DOI: 10.1128/cmr.00008-11
PMC: PMC3131058
OpenAlex: W2171827842
Cited by: 492
References: 569
Citations by year: 2026: 13 · 2025: 33 · 2024: 32 · 2023: 28 · 2022: 29 · 2021: 45 · 2020: 48 · 2019: 38 · 2018: 22 · 2017: 28 · 2016: 46 · 2015: 37 · 2014: 39 · 2013: 24 · 2012: 27
FWCI: 3.37
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: journals.asm.org/non-commercial-tdm-license (tdm)
Locations: Clinical Microbiology Reviews (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Data Archiving and Networked Services (DANS) (submittedVersion)
Pure Amsterdam UMC (submittedVersion)
Topics: Life Sciences › Immunology and Microbiology › Microbiology › Bacterial Infections and Vaccines
Health Sciences › Medicine › Epidemiology › Pneumonia and Respiratory Infections
Health Sciences › Medicine › Infectious Diseases › Streptococcal Infections and Treatments
Keywords: pneumococcal meningitis, Streptococcus pneumoniae, pathogenesis, pathophysiology, nasopharyngeal carriage, epithelial cell adhesion, blood-brain barrier penetration, complement activation, coagulation, microglia, neutrophil recruitment, cerebrospinal fluid pleocytosis, cochlear damage, cerebral edema, hydrocephalus, cerebrovascular complications, animal models, adjunctive therapy, antimicrobial therapy
MeSH terms: Animals, Humans, Inflammation, Meningitis, Pneumococcal, Streptococcus pneumoniae

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