Klebsiella pneumoniae carbapenemase variants: the new threat to global public health

Performance standards for antimicrobial susceptibility testing

Ferraro, M. J. (2001) · Cited by 9,780

Discovery, research, and development of new antibiotics: the WHO priority list of antibiotic-resistant bacteria and tuberculosis

Tacconelli, E., Carrara, E., Savoldi, A., Harbarth, S., Mendelson, M., Monnet, D. L., Pulcini, C., Kahlmeter, G., Kluytmans, J., Carmeli, Y., et al. (2018) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(17)30753-3 · Cited by 6,142

Emergence of plasmid-mediated colistin resistance mechanism MCR-1 in animals and human beings in China: a microbiological and molecular biological study.

Liu, Y.-Y., Wang, Y., Walsh, T., Yi, L.-X., Zhang, R., Spencer, J., Doi, Y., Tian, G.-B., Dong, B.-L., Huang, X.-H., et al. (2016) · Lancet. Infectious Diseases (Print) · doi:10.1016/s1473-3099(15)00424-7 · Cited by 4,920

Novel Carbapenem-Hydrolyzing β-Lactamase, KPC-1, from a Carbapenem-Resistant Strain of Klebsiella pneumoniae

Yigit, H., Queenan, A. M., Anderson, G. J., Domenech-Sanchez, A., Biddle, J. W., Steward, C. D., Alberti, S., Bush, K., & Tenover, F. C. (2001) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.45.4.1151-1161.2001 · Cited by 1,639

Colistin: the re-emerging antibiotic for multidrug-resistant Gram-negative bacterial infections

Li, J., Nation, R. L., Turnidge, J. D., Milne, R. W., Coulthard, K. P., Rayner, C. R., & Paterson, D. L. (2006) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(06)70580-1 · Cited by 1,389

Treatment Options for Carbapenem-resistant Gram-negative Bacterial Infections

Doi, Y. (2019) · Clinical Infectious Diseases · doi:10.1093/cid/ciz830 · Cited by 661

Carbapenemase-producing Klebsiella pneumoniae: molecular and genetic decoding

Chen, L., Mathema, B., Chavda, K. D., DeLeo, F. R., Bonomo, R. A., & Kreiswirth, B. N. (2014) · Trends in Microbiology · doi:10.1016/j.tim.2014.09.003 · Cited by 554

Infectious Diseases Society of America 2022 Guidance on the Treatment of Extended-Spectrum β-lactamase Producing Enterobacterales (ESBL-E), Carbapenem-Resistant Enterobacterales (CRE), and Pseudomonas aeruginosa with Difficult-to-Treat Resistance (DTR- P. aeruginosa )

Tamma, P. D., Aitken, S. L., Bonomo, R. A., Mathers, A. J., van Duin, D., & Clancy, C. J. (2022) · Clinical Infectious Diseases · doi:10.1093/cid/ciac268 · Cited by 554

New β-Lactam–β-Lactamase Inhibitor Combinations

Yahav, D., Giske, C. G., Grāmatniece, A., Abodakpi, H., Tam, V. H., & Leibovici, L. (2020) · Clinical Microbiology Reviews · doi:10.1128/cmr.00115-20 · Cited by 550

Molecular Epidemiology of KPC-Producing Klebsiella pneumoniae Isolates in the United States: Clonal Expansion of Multilocus Sequence Type 258

Kitchel, B., Rasheed, J. K., Patel, J. B., Srinivasan, A., Navon‐Venezia, S., Carmeli, Y., Brolund, A., & Giske, C. G. (2009) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00126-09 · Cited by 523

Medicinal plants: bioactive compounds, biological activities, combating multidrug-resistant microorganisms, and human health benefits - a comprehensive review

El‐Saadony, M. T., Saad, A. M., Mohammed, D. M., Korma, S. A., Alshahrani, M. Y., Ahmed, A. E., Ibrahim, E. H., Salem, H. M., Alkafaas, S. S., Saif, A. M., et al. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1491777 · Cited by 291

Hypervirulent and carbapenem-resistant Klebsiella pneumoniae: A global public health threat

Lei, T.-Y., Liao, B.-B., Yang, L.-R., Wang, Y., & Chen, X.-B. (2024) · Microbiological Research · doi:10.1016/j.micres.2024.127839 · Cited by 140

ESKAPE in China: epidemiology and characteristics of antibiotic resistance

Luo, Q., Lu, P., Chen, Y., Shen, P., Zheng, B., Ji, J., Ying, C., Liu, Z., & Xiao, Y. (2024) · Emerging Microbes & Infections · doi:10.1080/22221751.2024.2317915 · Cited by 122

Epidemiology and Genetic Traits of Carbapenemase-Producing Enterobacterales: A Global Threat to Human Health

Alvisi, G., Curtoni, A., Fonnesu, R., Piazza, A., Signoretto, C., Piccinini, G., Sassera, D., & Gaibani, P. (2025) · Antibiotics · doi:10.3390/antibiotics14020141 · Cited by 97

Management of intra-abdominal infections: recommendations by the Italian council for the optimization of antimicrobial use

Sartelli, M., Tascini, C., Coccolini, F., Dellai, F., Ansaloni, L., Antonelli, M. M., Bartoletti, M., Bassetti, M., Boncagni, F., Carlini, M., et al. (2024) · World Journal of Emergency Surgery · doi:10.1186/s13017-024-00551-w · Cited by 66

In vitro activity of cefepime-enmetazobactam on carbapenem-resistant Gram negatives

Bonnin, R. A., Jeannot, K., Henriksen, A. S., Quevedo, J., & Dortet, L. (2024) · Clinical Microbiology and Infection · doi:10.1016/j.cmi.2024.09.031 · Cited by 52

Antimicrobial resistance profile of clinical isolates from hospitals across China: CHINET 2024 surveillance report

Guo, Y. B., Ding, L., Han, R., Yin, D., Wu, S., Yang, Y., Wang, F., Zhu, D., Hu, F., & the China Antimicrobial Surveillance Network (CHINET) Study Group (2025) · One Health Advances · doi:10.1186/s44280-025-00092-0 · Cited by 38

Metabolic state-driven nutrient-based approach to combat bacterial antibiotic resistance

Peng, B., Li, H., & Peng, X. (2025) · npj Antimicrobials and Resistance · doi:10.1038/s44259-025-00092-5 · Cited by 43

Molecular mechanisms responsible KPC-135-mediated resistance to ceftazidime-avibactam in ST11-K47 hypervirulent Klebsiella pneumoniae

Shi, Q., Shen, S., Tang, C., Ding, L., Guo, Y. P., Yang, Y., Wu, S., Han, R., Yin, D., & Hu, F. (2024) · Emerging Microbes & Infections · doi:10.1080/22221751.2024.2361007 · Cited by 30

Rapid emergence, transmission, and evolution of KPC and NDM coproducing carbapenem-resistant Klebsiella pneumoniae

Li, J., Wu, W., Wu, H., Huang, J., Li, Z., Wang, J., Zhou, Z., Wu, M., Wu, X., Zhao, Y., et al. (2025) · Microbiological Research · doi:10.1016/j.micres.2025.128049 · Cited by 29

In vivo development of resistance to novel β-lactam/β-lactamase inhibitor combinations in KPC-producing Klebsiella pneumoniae infections: a case series

Boattini, M., Bianco, G., Comini, S., Costa, C. S., & Gaibani, P. (2024) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-024-04958-w · Cited by 26

In vitro activity and genomic characterization of KPC-producing Klebsiella pneumoniae clinical blood culture isolates resistant to ceftazidime/avibactam, meropenem/vaborbactam, imipenem/relebactam: an Italian nationwide multicentre observational study (2022–23)

Bianco, G., Boattini, M., Lupo, L. I., Ambretti, S., Greco, R., Degl’Innocenti, L., Ranieri, S. C., Fasciana, T., Mazzariol, A., Gibellini, D., et al. (2024) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkae450 · Cited by 26

Multiple mechanisms mediate aztreonam-avibactam resistance in Klebsiella pneumoniae: Driven by KPC-2 and OmpK36 mutations

Xiang, X., Kong, J., Zhang, J., Zhang, X., Qian, C., Zhou, T., & Sun, Y. (2024) · International Journal of Antimicrobial Agents · doi:10.1016/j.ijantimicag.2024.107425 · Cited by 26

In vitro mimicry of in vivo KPC mutations by ceftazidime-avibactam: phenotypes, mechanisms, genetic structure and kinetics of enzymatic hydrolysis

Shen, S., Tang, C., Yang, W., Ding, L., Han, R., Shi, Q., Guo, Y. P., Yin, D., & Hu, F. (2024) · Emerging Microbes & Infections · doi:10.1080/22221751.2024.2356146 · Cited by 24

Artificial intelligence-clinical decision support system for enhanced infectious disease management: Accelerating ceftazidime-avibactam resistance detection in Klebsiella pneumoniae

Lin, T., Chung, H., Jian, M., Chang, C., Lin, H., Yu, C.-M., Perng, C., Chang, F., Chen, C., Chiu, C.-H., et al. (2024) · Journal of Infection and Public Health · doi:10.1016/j.jiph.2024.102541 · Cited by 23

Evolution of ceftazidime–avibactam resistance driven by mutations in double-copy bla KPC-2 to bla KPC-189 during treatment of ST11 carbapenem-resistant Klebsiella pneumoniae

Zhang, X., Xie, Y., Zhang, Y., Lei, T., Zhou, L., Yao, J., Liu, L., Liu, H., He, J., Yu, Y., et al. (2024) · mSystems · doi:10.1128/msystems.00722-24 · Cited by 22

Comparison of three colloidal gold immunoassays and GeneXpert Carba-R for the detection of Klebsiella pneumoniae bla KPC-2 variants

Zhang, J.-M., Xu, J., Shen, S., Ding, L., Yang, W., Tang, C., Shi, Q., Zhao, H., Guo, Y., Han, R., et al. (2024) · Journal of Clinical Microbiology · doi:10.1128/jcm.00154-24 · Cited by 22

Next-generation diagnostics of bloodstream infections enabled by rapid whole-genome sequencing of bacterial cells purified from blood cultures

Pilato, V. D., Bonaiuto, C., Morecchiato, F., Antonelli, A., Giani, T., & Rossolini, G. M. (2025) · EBioMedicine · doi:10.1016/j.ebiom.2025.105633 · Cited by 20

Higher prevalence of hypervirulent Klebsiella pneumoniae isolates with high-risk multidrug resistance in Asia

Gan, L., Mao, P., Tian, Z., Li, X., Yu, Z., Du, B., Xue, G., Yan, C., Cui, J., Zhao, H., et al. (2025) · Journal of Infection and Public Health · doi:10.1016/j.jiph.2025.102834 · Cited by 20

Can we escape from top-priority ESKAPE pathogens?

Zeng, L., Feng, Y., & Wang, M. (2026) · Emerging Microbes & Infections · doi:10.1080/22221751.2026.2614739 · Cited by 23

Past, present, and future perspectives on aztreonam and avibactam

Bush, K. (2025) · Expert Review of Anti-infective Therapy · doi:10.1080/14787210.2025.2473047 · Cited by 17

Characterization of a novel KPC-2 variant, KPC-228, conferring resistance to ceftazidime–avibactam in an ST11-KL64 hypervirulent Klebsiella pneumoniae

Zhou, P., Gao, H., Li, M., Wu, C., Wan, C., Wan, C., Shen, L., Yuan, X., Shi, J., Huang, Y., et al. (2024) · International Journal of Antimicrobial Agents · doi:10.1016/j.ijantimicag.2024.107411 · Cited by 16

Coexistence of blaNDM-5, blaCTX-M-15, blaOXA-232, blaSHV-182 genes in multidrug-resistant K. pneumoniae ST437-carrying OmpK36 and OmpK37 porin mutations: First report in Italy

Marcantonio, S. D., Perilli, M., Alloggia, G., Segatore, B., Miconi, G., Bruno, G., Frascaria, P., & Piccirilli, A. (2024) · Journal of Global Antimicrobial Resistance · doi:10.1016/j.jgar.2024.02.015 · Cited by 16

Resistance development to new anti-Gram negatives antibiotics during treatment: geographical epidemiology and risk factors

Falcone, M., Tiseo, G., & Shields, R. K. (2026) · Clinical Microbiology and Infection · doi:10.1016/j.cmi.2026.01.031 · Cited by 19

Diversity of mobile genetic elements in carbapenem-resistant Enterobacterales isolated from the intensive care units of a tertiary care hospital in Northeast India

Mitra, S., Naha, S., Chakraborty, J., De, S., Kaur, H., Majumdar, T. K., & Basu, S. (2025) · Frontiers in Microbiology · doi:10.3389/fmicb.2025.1543427 · Cited by 14

A pre-post quasi-experimental study of antimicrobial stewardship exploring the impact of a multidisciplinary approach aimed at attaining an aggressive joint pharmacokinetic/pharmacodynamic target with ceftazidime/avibactam on treatment outcome of KPC-producing Klebsiella pneumoniae infections and on ceftazidime/avibactam resistance development

Gatti, M., Rinaldi, M., Cojutti, P. G., Bonazzetti, C., Siniscalchi, A., Tonetti, T., Ambretti, S., Tedeschi, S., Giannella, M., Viale, P., et al. (2025) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00488-25 · Cited by 14

Boron Compounds as Key Drivers of Innovation: Exploring Their Role in Environmental Remediation, Sustainable Agriculture, Advanced Biomedical Applications, and Green Chemistry

Yıldırım, M., Erşatır, M., Saleh, M., Demirbağ, B., Yabalak, E., & Kılıç, A. (2025) · Journal of Organometallic Chemistry · doi:10.1016/j.jorganchem.2025.123688 · Cited by 12

Emergence of ceftazidime-avibactam resistance in blaKPC-33-harbouring ST11 Klebsiella pneumoniae in a paediatric patient

Zhou, J., Yan, G., Tang, C., Liu, J., Fu, P., Li, D., Yang, W., Guo, Y. P., Wang, C., Lü, G., et al. (2024) · International Journal of Antimicrobial Agents · doi:10.1016/j.ijantimicag.2024.107163 · Cited by 12

Resistance mechanisms and therapeutic strategies for Pseudomonas aeruginosa infections

Meletis, G., & Karastergiou, E. (2025) · Therapeutic Advances in Infectious Disease · doi:10.1177/20499361251388382 · Cited by 14

Clinical and Microbiological characteristics of patients with ceftazidime/avibactam-resistant Klebsiella pneumoniae carbapenemase (KPC)-producing K. pneumoniae strains

Liu, S.-Y., Chou, S.-H., Chuang, C., Juan, C.-H., Ho, Y.-C., Ho, H., Chen, L., & Lin, Y.-T. (2025) · Annals of Clinical Microbiology and Antimicrobials · doi:10.1186/s12941-025-00797-5 · Cited by 11

A Synergistic Approach to a Novel Nicotinamide–Tridecanoic Acid Cocrystal: Crystallization, Properties, Computational Insights, and Antibacterial Activity

Neto, J. G. D. O., Ramos, M. C., Lima, A. D. S. G., Nogueira, C. E. S., Ayala, A. P., Souto, E. B., Lang, R., de Sousa, F. F., & dos Santos, A. O. (2025) · Crystal Growth & Design · doi:10.1021/acs.cgd.5c00662 · Cited by 10

Exploring mutational possibilities of KPC variants to reach high level resistance to cefiderocol

Hanna, S., La, K., Yoshii, Y., Gits‐Muselli, M., Meouche, I. E., Benhadid-Brahmi, Y., Bonacorsi, S., & Birgy, A. (2025) · Scientific Reports · doi:10.1038/s41598-025-17044-8 · Cited by 10

Are New β-Lactam/β-Lactamase Inhibitor Combinations Promising Against Carbapenem-Resistant K. pneumoniae Isolates?

Ceylan, A. N., Kömeç, S., Şanlı, K., Öncel, B., Durmuş, M. A., & Gülmez, A. (2025) · Pathogens · doi:10.3390/pathogens14030220 · Cited by 10

Evaluation of phenotypic and genotypic methods for detecting KPC variants

Benhadid-Brahmi, Y., Hobson, C. A., Abdelmoumene, L., Jaouen, E., Magnan, M., Gits‐Muselli, M., Lescat, M., Tenaillon, O., Bonacorsi, S., & Birgy, A. (2025) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00082-25 · Cited by 10

Diverse modes of ceftazidime/avibactam resistance acquisition in carbapenem-resistant Klebsiella pneumoniae and Pseudomonas aeruginosa from a Chinese intensive care unit

Zhou, J., Chen, M., Liang, M., Han, X., Weng, R., Li, Y., Jiang, Y., Hua, X., Du, X., Wang, W., et al. (2025) · Annals of Clinical Microbiology and Antimicrobials · doi:10.1186/s12941-025-00800-z · Cited by 10

A comparative study of genotyping and antimicrobial resistance between carbapenem-resistant Klebsiella pneumoniae and Acinetobacter baumannii isolates at a tertiary pediatric hospital in China

Jian, X., Li, Y., Wang, H., Li, C., Li, F., Li, J., Dong, J., Du, T., & Jiang, L. (2024) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2024.1298202 · Cited by 9

Comparing antibiotic resistance and virulence profiles of Enterococcus faecium, Klebsiella pneumoniae, and Pseudomonas aeruginosa from environmental and clinical settings

Denissen, J., Havenga, B., Reyneke, B., Khan, S., & Khan, W. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e30215 · Cited by 9

Meropenem–Vaborbactam for Treatment of Carbapenem-Resistant Enterobacterales: A Narrative Review of Clinical Practice Evidence

Bassetti, M., Giacobbe, D. R., Vena, A., Poulakou, G., Rossolini, G. M., Soriano, À., & Nicolau, D. P. (2025) · Infectious Diseases and Therapy · doi:10.1007/s40121-025-01146-x · Cited by 9

In vitro and in vivo antibacterial efficacy of bacteriophage combined with tigecycline against carbapenem-resistant Klebsiella pneumoniae and characterization of phage resistant mutants

Zhu, R., Wang, R., Fei, B., Lu, R., You, X., Liu, X., Wang, C., & Li, Y. (2025) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2025.1610625 · Cited by 9

Spread and evolution of blaKPC-plasmid between Serratia marcescens and Klebsiella pneumoniae

Yang, W., Tang, C., Shen, S., Shi, Q., & Hu, F. (2024) · International Journal of Antimicrobial Agents · doi:10.1016/j.ijantimicag.2024.107149 · Cited by 9

Impact of extended-spectrum chromosomal AmpC (ESAC) of Escherichia coli on susceptibility to cefiderocol

Raro, O. H. F., Terrier, C. L., Nordmann, P., & Poirel, L. (2024) · Microbiology Spectrum · doi:10.1128/spectrum.00704-24 · Cited by 9

Detection of KPC-216, a Novel KPC-3 Variant, in a Clinical Isolate of Klebsiella pneumoniae ST101 Co-Resistant to Ceftazidime-Avibactam and Cefiderocol

Giufrè, M., Errico, G., Grosso, M. D., Pagnotta, M., Palazzotti, B., Ballardini, M., Pantosti, A., Meledandri, M., & Monaco, M. (2024) · Antibiotics · doi:10.3390/antibiotics13060507 · Cited by 8

Identification of a Novel KPC Variant, KPC-204, Conferring Resistance to Both Carbapenems and Ceftazidime–Avibactam in an ST11 Klebsiella pneumoniae Strain

Gong, Y., Feng, Y., & Lv, X. (2024) · Microorganisms · doi:10.3390/microorganisms12061193 · Cited by 8

Enhanced invasion and survival of antibiotic- resistant Klebsiella pneumoniae pathotypes in host cells and strain-specific replication in blood

Klaper, K., Pfeifer, Y., Heinrich, L., Prax, M., Krut, O., Bekeredjian‐Ding, I., Wahl, A., Fischer, M. A., Kaspar, H., Borgmann, S., et al. (2025) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2025.1522573 · Cited by 8

Global quantitative proteome analysis of a multi-resistant Klebsiella pneumoniae strain

Illenseher, M.-S., Hentschker, C., Salazar, M. G., Busch, L. M., Zierke, L., Reder, A., Michalik, S., Völker, U., Hammerschmidt, S., & Surmann, K. (2025) · Frontiers in Microbiology · doi:10.3389/fmicb.2025.1528869 · Cited by 9

Chemically tailored anionic antibiotic adjuvants targeting divalent cations to overcome carbapenem resistance in gram-negative bacteria

Tang, H., Zhao, X., Sun, M., Qi, J., Huang, Z., Zhu, Y., Zeng, Y., Xia, Y., Luo, Z., & Jiang, X. (2025) · Science Advances · doi:10.1126/sciadv.adz0574 · Cited by 8

Antibiotic Resistance and Virulence Mechanisms in Klebsiella pneumoniae: Understanding for Better Interventions

Abebe, A. A., Birhanu, A. G., & Tessema, T. S. (2026) · Bacteria · doi:10.3390/bacteria5010009 · Cited by 11

Complete Genome Sequence of a Klebsiella pneumoniae Strain Carrying Novel Variant blaKPC-203, Cross-Resistant to Ceftazidime/Avibactam and Cefiderocol, but Susceptible to Carbapenems, Isolated in Italy, 2023

Amadesi, S., Bianco, G., Secci, B., Fasciana, T., Boattini, M., Costa, C. S., & Gaibani, P. (2024) · Pathogens · doi:10.3390/pathogens13060507 · Cited by 8

Identification of blaKPC-90 in Klebsiella pneumoniae associated with ceftazidime-avibactam resistance and the translocation & truncation of resistant genes mediated by IS26

Yang, W., Xu, H., Zhao, Y., Chen, W., Ma, X., & Hu, F. (2024) · International Journal of Antimicrobial Agents · doi:10.1016/j.ijantimicag.2024.107388 · Cited by 8

Overexpression of bla SHV-12 caused by tandem amplification contributed to ceftazidime/avibactam resistance in hypervirulent and carbapenem-resistant Klebsiella pneumoniae

Liu, C., Yi, J., Yang, P., Du, C., Jiang, F., Lu, M., Du, P., & Shen, N. (2024) · Emerging Microbes & Infections · doi:10.1080/22221751.2024.2426481 · Cited by 7

Ceftazidime-avibactam treatment dilemma of blaKPC−2-containing Klebsiella pneumoniae due to the development of co-existence of mixed strains carrying blaKPC−2 or blaKPC−33 in lung transplant recipients

Lei, Z., Li, Z., Zhang, Y., Zeng, L., Wu, Y., Zhang, F., Yang, X., Liu, X., Liu, Q., Ma, Y., et al. (2024) · Annals of Clinical Microbiology and Antimicrobials · doi:10.1186/s12941-024-00743-x · Cited by 7

Clinical evaluation of advanced MALDI-TOF MS for carbapenemase subtyping in Gram-negative isolates

Cheon, D. H., Jang, H.-J., Choi, Y. K., Oh, W. S., Hwang, S., Park, J.-R., Kim, H.-J., Park, Y., Lee, S., Yang, W. S., et al. (2024) · Journal of Clinical Microbiology · doi:10.1128/jcm.01475-24 · Cited by 7

Whole-genome sequencing characterisation of a new KPC-245 variant-carrying Klebsiella pneumoniae strain isolated from a transplanted patient and resistant to ceftazidime/avibactam, meropenem/vaborbactam and imipenem/relebactam

Vaiana, C., Vazzana, R., Castelbuono, S., Cona, A., Mularoni, A., Minucci, R., Monaco, F., Carlo, D. D., Conaldi, P. G., Gallo, A., et al. (2025) · Journal of Global Antimicrobial Resistance · doi:10.1016/j.jgar.2025.03.006 · Cited by 7

Ceftazidime-avibactam resistance in Klebsiella pneumoniae: A growing public health concern across diverse sublineages, 2019–2024

Gonçalves, A. B. R., Alves, V., Neves, I., Read, A., Peixe, L. M. S. V., & Novais, Â. (2025) · Journal of Global Antimicrobial Resistance · doi:10.1016/j.jgar.2025.06.016 · Cited by 7

Global trends in carbapenem-resistant gram-negative bacteria research (2020–2025): a bibliometric analysis and systematic review

Zhang, X., Zhang, C., Lv, M., Wang, S., Wang, Q., Yang, C., Zhao, Q., Ma, L., Li, B., Qin, X., et al. (2025) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2025.1690417 · Cited by 7

AIE‐Active Antibacterial Photosensitizer Disrupting Bacterial Structure: Multicenter Validation against Drug‐Resistant Pathogens

Zhong, G., Deng, S., Hong, Y., Zhou, F., Liang, D., Lin, Y., Yang, L., Guan, Y., Pan, C., Yan, L., et al. (2025) · Small Methods · doi:10.1002/smtd.202401663 · Cited by 7

ICU environment as a reservoir of KPC-ST307-Klebsiella pneumoniae high-risk clone resistant to ceftazidime-avibactam

Hernández-García, M., Nieto-Torres, M., Guerra-Pinto, N., Castillo-Polo, J. A., de la Fuente, J. S., Michelena, M., Alonso, M. P., Soriano, C., Pérez, C. D.-A., Cantón, R., et al. (2025) · Scientific Reports · doi:10.1038/s41598-025-14987-w · Cited by 6

Ceftazidime-avibactam tolerance and persistence among difficult-to-treat KPC-producing Klebsiella pneumoniae clinical isolates from bloodstream infections

Abichabki, N. D. L. M., Gaspar, G. G., Bortolato, L. R., Lima, D. A. F. S., Silva, L. N., Pocente, R. H. C., Ferreira, J. C., Ogasawara, T. C., Pereira, D. M., Guerra, R. R., et al. (2024) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-024-05005-4 · Cited by 7

Adaptive evolution of extensive drug resistance and persistence in epidemic ST11 KPC-producing Klebsiella pneumoniae during antimicrobial chemotherapy

Li, T., Zhu, Y., Xiang, G., Xu, Z., Yang, H., Li, M., & Shen, Z. (2024) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01235-24 · Cited by 6

Characterization of Klebsiella pneumoniae carbapenemase (KPC)-14, a KPC variant conferring resistance to ceftazidime-avibactam in the extensively drug-resistant ST463 Pseudomonas aeruginosa clinical isolate

Xiao, Y., Wang, L., Jia, H., Jiang, Y., Li, Y., Han, J., Li, S., Gu, Y., & Yang, Q. (2025) · Journal of Global Antimicrobial Resistance · doi:10.1016/j.jgar.2025.03.004 · Cited by 6

Performance of two immunochromatographic tests in detecting KPC variants conferring resistance to ceftazidime-avibactam

de Lima, A. V., Lima, K. D. O., Rocha, D. A. D. C., Cappellano, P., Boszczowski, Í., Sampaio, S. C. F., & Sampaio, J. L. M. (2024) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-024-04815-w · Cited by 6

Global phylogeography and genetic characterization of carbapenem and ceftazidime-avibactam resistant KPC-33-producing Pseudomonas aeruginosa

Zhou, L., Yao, J., Zhang, Y., Zhang, X., Hu, Y., Liu, H., He, J., Yu, Y., Chen, M., Tu, Y., et al. (2025) · npj Antimicrobials and Resistance · doi:10.1038/s44259-024-00073-0 · Cited by 5

Raising the Bar of PK/PD Target Attainment of Beta-Lactams in Daily Clinical Practice: An Effective Strategy to Overcome Resistance Development to Novel Beta-Lactams?

Gatti, M., & Pea, F. (2025) · Infectious Disease Reports · doi:10.3390/idr18010003 · Cited by 5

Molecular Epidemiological Characteristics of blaIMP-4-Carrying Klebsiella pneumoniae ST-11 in Hospitalized Patients

Xue, Y., Zhang, D., Du, S., Chen, D., Liu, S., Peng, T., Li, C., Zhang, J., & Wang, X. (2025) · Infection and Drug Resistance · doi:10.2147/idr.s482713 · Cited by 5

Diverse evolutionary trajectories of Klebsiella pneumoniae carbapenemase: unraveling the impact of amino acid substitutions on β-lactam susceptibility and the role of avibactam in driving resistance

Wei, J., Huang, J., Zou, C., Shen, S., Kreiswirth, B. N., Huang, A., Huang, S., Chen, L., Wang, D., & Niu, S. (2025) · mSystems · doi:10.1128/msystems.00184-25 · Cited by 5

Comparison of CRISPR-Cas9, CRISPR-Cas12f1, and CRISPR-Cas3 in eradicating resistance genes KPC-2 and IMP-4

Huang, J., Ding, K., Chen, J., Fan, J. J., Huang, L., Qiu, S., Wang, L., Du, X., Wang, C., Pan, H., et al. (2025) · Microbiology Spectrum · doi:10.1128/spectrum.02572-24 · Cited by 5

Emergence of ceftazidime-avibactam resistance in clinical Klebsiella pneumoniae during therapy

Shen, S., Deng, X., Guo, L., Yang, L., Yu, H., Hu, F., & Huang, X. (2025) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-025-05180-y · Cited by 5

Within-host resistance evolution of ST15 Klebsiella pneumoniae in an ICU immunosuppressed patient under antibiotic pressure of polymyxins, ceftazidime-avibactam, and meropenem

Tang, B., Meng, T., Tian, L., Zhong, M., Dai, Y., Tian, R., Pan, T., Sun, J., Tan, R., Wang, X., et al. (2025) · International Journal of Antimicrobial Agents · doi:10.1016/j.ijantimicag.2025.107554 · Cited by 5

KPC-157 and KPC-181 carbapenemases produced by Citrobacter freundii ST522 and Klebsiella pneumoniae ST258 isolated from wastewater

Furlan, J. P. R., Bueno, G. C., Carmo, R. R. D. S., Silva, R. L. O., Barbosa, M. R. F., Sato, M. I. Z., Brunetti, F., Power, P. P., Lincopán, N., & Schenkman, S. (2025) · Molecular Biology Reports · doi:10.1007/s11033-025-10801-y · Cited by 5

Genomic characterization of a blaKPC-2–producing IncM2 plasmid harboring transposon ΔTn6296 in Klebsiella michiganensis

Song, J.-M., Long, H.-B., Ye, M., Yang, B.-R., Wu, G., he, H., Wang, J.-L., Li, H.-W., Li, X.-G., Deng, D., et al. (2024) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2024.1492700 · Cited by 5

Beyond the Spotlight: Enterobacter spp. as Overlooked Carbapenemase Producers in Europe

Cirkovic, I. B., & Brkić, S. (2025) · Antibiotics · doi:10.3390/antibiotics14101045 · Cited by 4

Development of ceftazidime–avibactam resistance driven by conversion of blaKPC-2 to blaKPC-78 during treatment of ST463 carbapenem-resistant Pseudomonas aeruginosa infection

Xu, H., Zhang, T., Cui, X., Guo, J., Min, P., Wu, C., Tang, X., Zhou, L., Wang, L., & Li, X. (2025) · International Journal of Antimicrobial Agents · doi:10.1016/j.ijantimicag.2025.107703 · Cited by 4

Emergence and clonal dissemination of KPC-2- and NDM-1-coharboring Citrobacter freundii in China with an IncR plasmid

Zhou, J., Zhen, M., Gao, K., Lu, X., Zhang, D., & Yang, J. (2024) · Microbiology Spectrum · doi:10.1128/spectrum.01953-24 · Cited by 4

Spontaneous Emergence of Cefiderocol Resistance in Klebsiella pneumoniae KPC-163: Genomic and Transcriptomic Insights

Luu, I., Mezcord, V., Escalante, J., Traglia, G. M., Tuttobene, M. R., Rodriguez, C., Cheng, C. F., Vallé, Q., Sharma, R., Tolmasky, M. E., et al. (2025) · Antibiotics · doi:10.3390/antibiotics14080832 · Cited by 4

Characterization of ertapenem-resistant Enterobacterales in Canadian hospitals: 17 years of the CANWARD study (2007–23)

Mataseje, L. F., Lerminiaux, N. A., Lagacé-Wiens, P. R. S., Walkty, A. J., Adam, H. J., Poutanen, S. M., Baxter, M. R., Karlowsky, J. A., McCracken, M., Golding, G. R., et al. (2025) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkaf221 · Cited by 4

Emergence of ST23-K1 blaKPC-3-positive hypervirulent carbapenem-resistant Klebsiella pneumoniae from China: A molecular, biological, and epidemiological study

Xin, L., Wang, J., Qin, C., Sun, Y., Zhou, H., Zhang, R., & Chen, G. (2025) · Journal of Global Antimicrobial Resistance · doi:10.1016/j.jgar.2025.09.007 · Cited by 4

Antibiotics for Intra-Abdominal Infections: When, Which, How and How Long?

Sartelli, M., Palmieri, M., & Labricciosa, F. M. (2025) · Antibiotics · doi:10.3390/antibiotics14111127 · Cited by 6

Plasmid-associated clonal expansion drives department-preference transmission of carbapenem-resistant Klebsiella pneumoniae in Xi’an, China: a genomic epidemiology study

Luo, K., Liu, S., Feng, J., Li, R., Zhang, S., Rong, Y., Li, F., Li, Y., Wu, K., Wang, J., et al. (2025) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2025.1617222 · Cited by 5

Compound amino acid synergizes ceftazidime-avibactam to eradicate extracellular and facultative intracellular MDR pathogens

Xiang, J., Zhou, Y., Yuan, S.-C., Zhang, X.-L., Wang, S.-W., Chen, Z., Lin, L.-R., Liu, Z.-Q., Li, H., & Peng, B. (2026) · Cell Reports · doi:10.1016/j.celrep.2026.117008 · Cited by 5

A large-scale surveillance revealed that KPC variants mediated ceftazidime-avibactam resistance in clinically isolated Klebsiella pneumoniae

Qiao, S., Xin, S., Zhu, Y., Zhao, F., Wu, H., Zhang, J., Yao, B., Yu, Y., Fu, Y., Jiang, Y., et al. (2024) · Microbiology Spectrum · doi:10.1128/spectrum.00258-24 · Cited by 4

Frequencies and mechanisms of mutational resistance to ceftibuten/avibactam in Enterobacterales

Mushtaq, S., Vickers, A. A., Doumith, M., Garello, P., Woodford, N., & Livermore, D. M. (2024) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkae452 · Cited by 4

Integrating an LFA Carbapenemase Detection System into the Laboratory Diagnostic Routine: Preliminary Data and Effectiveness Against Enzyme Variants

Calvo, M., Maugeri, G., Bongiorno, D., Migliorisi, G., & Stefani, S. (2025) · Diagnostics · doi:10.3390/diagnostics15111434 · Cited by 4

Transcriptomic Analysis Reveals Key Regulatory Genes and Pathways Involved in Macrophage Inflammation Induced by Hypervirulent Klebsiella pneumoniae Infection

Bi, J., Huang, X., Meng, L., Li, J., He, Y., Jin, J., & Li, T. (2025) · Current Microbiology · doi:10.1007/s00284-025-04481-x · Cited by 3

Molecular characterisation of two novel KPC variants mediating ceftazidime-avibactam resistance in ST11 Klebsiella pneumoniae

Guo, T., Li, D., Shen, S., Tang, C., Jiang, T., & Hu, F. (2025) · International Journal of Antimicrobial Agents · doi:10.1016/j.ijantimicag.2025.107642 · Cited by 3

Deciphering shared receptor usage in genomically unrelated bacteriophages infecting hypervirulent Klebsiella pneumoniae K1 ST23

Selpiev, Z., Leptihn, S., Müsken, M., & Loh, B. (2025) · FEMS Microbes · doi:10.1093/femsmc/xtaf014 · Cited by 3

Unravelling tandem repeat-mediated mutagenesis drive rapid diversification of KPC enzymes: emergence of blaKPC-263 and enhanced resistance to ceftazidime-avibactam

Ye, H., Liu, R., Shen, J., Yang, W., Hu, T., Liu, X., Wang, K., Gong, L., Xu, H., Zhu, J., et al. (2025) · EBioMedicine · doi:10.1016/j.ebiom.2025.105979 · Cited by 4

Exposure to ceftazidime-avibactam induced antimicrobial resistance and enhanced virulence in a Klebsiella pneumoniae strain

Li, W., Wang, H., Liu, Z., Xia, Y., Hu, Y., Wang, H., Xia, F., & Zou, M. (2025) · iScience · doi:10.1016/j.isci.2025.113844 · Cited by 3

Characterization of genetic context of blaKPC in Pseudomonas aeruginosa

Chen, M., Deng, T., Li, X., Zhou, R., Gao, Z., Zhou, D., Zhu, J., Li, J., Chen, X., Wang, M., et al. (2025) · Frontiers in Microbiology · doi:10.3389/fmicb.2025.1666175 · Cited by 3

Avoiding resistance development to newer drugs: open research lines

Rinaldi, M., Gatti, M., & Giannella, M. (2025) · Clinical Microbiology and Infection · doi:10.1016/j.cmi.2025.11.009 · Cited by 3

Environmental reservoirs account for high levels of carbapenem resistance genes in wastewater

Schussman, M. K., Feng, S. K., Schmoldt, A., Bootsma, M. J., Dennis, K., Janssen, K. H., & McLellan, S. L. (2026) · Microbiology Spectrum · doi:10.1128/spectrum.01737-25 · Cited by 3

Characterization of the bacteriophage vB_KpnP_Henu1_3 lytic for K1 Klebsiella pneumoniae and its therapeutic efficacy in Galleria mellonella larvae and mice

Zhang, Y., Shi, L., Zhou, F., Li, J., Liu, M., Guo, S., Shi, X., Zhang, X., Qiao, D., Zhang, J., et al. (2026) · Microbiology Spectrum · doi:10.1128/spectrum.00931-25 · Cited by 3

Mechanisms of resistance to newer drugs against gram negative bacteria in enterobacterales

Delgado-Valverde, M., Pérez‐Palacios, P., & López‐Cerero, L. (2026) · Clinical Microbiology and Infection · doi:10.1016/j.cmi.2025.12.027 · Cited by 3

Investigation of the susceptibility rates to ceftazidime-avibactam and colistin, clonal relationships, and clinical data of patients with carbapenem-resistant Klebsiella pneumoniae isolates detected in the ICUs of a hospital in İstanbul

Akkaya, Y., Aydın, İ., Harmankaya, S., Karakuş, M., Aydin, M., Erdin, B. N., Yılmaz, A. M., Büyükavcı, E. H., Toraman, Z. A., & Kılıç, İ. H. (2026) · Annals of Saudi Medicine · doi:10.5144/0256-4947.2026.9 · Cited by 3

In vivo evolution of resistance to contemporary β-lactam/β-lactamase inhibitor combinations during treatment of a KPC-producing Serratia marcescens infection

Bailey, D. C., Castañeda-Barba, S., Barry, K. E., Treerat, P., Crawford, M. A., Hughes, M. A., & Mathers, A. J. (2026) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01651-25 · Cited by 3

Characterization of KPC-176, an S171P variant derived from KPC-2, associated with ceftazidime-avibactam resistance in ST11-KL64 Klebsiella pneumoniae

Hu, Y., Yuan, L., Xia, Z., Wan, T., Lu, Y., & Shen, J. (2026) · International Journal of Antimicrobial Agents · doi:10.1016/j.ijantimicag.2026.107773 · Cited by 3

Detection of β-lactam resistance genes in Gram-negative bacteria from positive blood cultures using a microchip-based molecular assay

Ivagnes, V., Maio, F. D., Baccani, I., Antonelli, A., Menchinelli, G., Rosato, R., Cafaro, G., Santarelli, G., Falletta, F., D’Inzeo, T., et al. (2025) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2025.1597700 · Cited by 3

CRISPR-Cas9 targeting the blaKPC gene in a clinical isolate of Klebsiella michiganensis: Reduction of imipenem resistance and changes in genomic carbapenem resistance determinants

Tagliaferri, T. L., Krüttgen, A., Mendes, T. A. D. O., dos Santos, S. G., & Horz, H. (2025) · PLoS ONE · doi:10.1371/journal.pone.0328521 · Cited by 3

Imipenem/Relebactam Plus Aztreonam: First Reported Use in MDR Klebsiella pneumoniae Sternal Infection Complicated by Bacteremia

Pipitò, L., Rubino, R., Immordino, R., Bono, E., Fasciana, T., Bonura, C., Giammanco, A., Argano, V., & Cascio, A. (2025) · Antibiotics · doi:10.3390/antibiotics14101007 · Cited by 3

MultiRapid ATB NP test for detecting concomitant susceptibility and resistance of last-resort novel antibiotics available to treat multidrug-resistant Enterobacterales infections

Raro, O. H. F., Bouvier, M., Kerbol, A., Poirel, L., & Nordmann, P. (2024) · International Journal of Antimicrobial Agents · doi:10.1016/j.ijantimicag.2024.107206 · Cited by 3

Bovine Neutrophil β-Defensin-5 Provides Protection against Multidrug-Resistant Klebsiella pneumoniae via Regulating Pulmonary Inflammatory Response and Metabolic Response

Zhu, S., Dai, D., Han, L., Huang, J., Kang, W., Yang, Y.-M., Zhong, Y., Xiang, Y., Liu, C., He, J., et al. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms251910506 · Cited by 2

First report of KPC variants conferring ceftazidime-avibactam resistance in Colombia: introducing KPC-197

Cadena, E. D. L., Mojica, M. F., Rojas, L. J., Castro, B. E., García-Betancur, J. C., Marshall, S. H., Restrepo-Arbeláez, N., Castro-Caro, N. P., Fonseca-Carrillo, M., Pallares, C., et al. (2024) · Microbiology Spectrum · doi:10.1128/spectrum.04105-23 · Cited by 9

Emergence of Ceftazidime‐Avibactam‐Induced KPC Variants (KPC‐25/127) in Intracranial Infection and Implications for Clinical Management

Lei, K., Tian, Y., Xiong, C., Lei, J., Chen, D., Bai, X., Abdul-Aziz, M. H., Xie, J., & Liu, Z. (2026) · MicrobiologyOpen · doi:10.1002/mbo3.70363

Klebsiella pneumoniae Carbapenemase Variants Resistant to Ceftazidime-Avibactam: an Evolutionary Overview

Hobson, C. A., Pierrat, G., Tenaillon, O., Bonacorsi, S., Berçot, B., Jaouen, E., Jacquier, H., & Birgy, A. (2022) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00447-22 · Cited by 226

Molecular characterisation of two novel KPC variants mediating ceftazidime-avibactam resistance in ST11 Klebsiella pneumoniae

Guo, T., Li, D., Shen, S., Tang, C., Jiang, T., & Hu, F. (2025) · International Journal of Antimicrobial Agents · doi:10.1016/j.ijantimicag.2025.107642 · Cited by 3

P-290. Clinical and microbiological characteristics of patients infected with ceftazidime/avibactam-resistant Klebsiella pneumoniae carbapenemase-producing K. pneumoniae strains

Liu, S.-Y., Chou, S.-H., Chuang, C., Ho, Y.-C., Juan, C.-H., & Lin, Y.-T. (2025) · Open Forum Infectious Diseases · doi:10.1093/ofid/ofae631.493