Klebsiella pneumoniae carbapenemase variants: the new threat to global public health

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Detection of KPC-producing Enterobacterales species in wastewater samples from the Gran Concepción Metropolitan area, Chile

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Rapid replacement of bla KPC variant in ST11 carbapenem-resistant and hypervirulent Klebsiella pneumoniae contributed to ceftazidime/avibactam resistance during severe in vivo infection

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PanARGMiner (Pan-Genomic Antimicrobial Resistance Gene Miner): An advanced feature selection framework for extracting key resistance genes from pan-genomic datasets

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Decoding Ceftazidime-Avibactam Resistance in Newly Identified Klebsiella pneumoniae Carbapenemase (KPC) 107 Variant by Modulating the Active Site Environment

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Fitness cost of ceftazidime–avibactam resistance acquisition in carbapenem-resistant hypervirulent Klebsiella pneumoniae

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Real-World Evidence and Multidrug Resistant Infections: How Can We Leverage RWE to Improve Patient Outcome with the Novel Beta-Lactam and Beta-Lactam/Beta-Lactamase Inhibitor Combinations

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Within-host evolution drives the emergence of ceftazidime-avibactam resistance mediated by IncN plasmid-encoded bla NDM-1 and bla KPC-33 in ST11-KL64 hypervirulent Klebsiella pneumoniae

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cirA promoter disruption and SHV-12 production contribute to cefiderocol resistance in carbapenem-resistant Klebsiella pneumoniae

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Antimicrobial activity of aztreonam–avibactam against KPC variant-producing Klebsiella pneumoniae with ceftazidime–avibactam resistance

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Ceftazidime–avibactam drives mutations, insertion, or overexpression in blaKPC-2 and enhances biofilm-forming ability of KPC-producing Klebsiella pneumoniae

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Aztreonam-avibactam for carbapenem-resistant Gram-negative infections: Mechanisms, clinical efficacy, the challenge of resistance and susceptibility testing

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Emerging Cross-Resistance to Cefiderocol and Ceftazidime-Avibactam in KPC-Producing Klebsiella pneumoniae During Ceftazidime-Avibactam Therapy

Riazzo, C., Elías-López, C., Muñoz-Rosa, M., Arjona-Torres, C., Blanco-Martín, T., Machuca, I., Torre‐Cisneros, J., Gracia-Ahufinger, I., Kieffer, N., Arca-Suárez, J., et al. (2026) · Antibiotics · doi:10.3390/antibiotics15070701 · Cited by 2

Effectiveness of Ceftazidime/Avibactam treatment for infections caused by Klebsiella pneumoniae Carbapenemase (KPC), a 30-day mortality perspective. Comparison of results with control groups treated with other antibiotics

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Double bla KPC-2 copies quadrupled minimum inhibitory concentration of ceftazidime–avibactam in hospital-derived Klebsiella pneumoniae

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Efficacy of meropenem against ceftazidime–avibactam-resistant Klebsiella pneumoniae producing KPC-31, KPC-33, KPC-90, KPC-106 and KPC-114

Pariona, J. G. M., Vásquez‐Ponce, F., Pariona, E. M. M., Carmo, R. R. D. S., Martins-Gonçalves, T., Becerra, J., de Lima, A. V., Moraes, G. F. Q., Sampaio, J. L. M., & Lincopán, N. (2024) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkae389 · Cited by 2

Predicting the Effect of Meropenem Against Klebsiella pneumoniae Using Minimum Inhibitory Concentrations Determined at High Inocula

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‘In vitro activity of cefepime-enmetazobactam on carbapenem-resistant gram negatives’—author's response

Bonnin, R. A., Jeannot, K., Henriksen, A. S., Quevedo, J., & Dortet, L. (2025) · Clinical Microbiology and Infection · doi:10.1016/j.cmi.2025.03.012 · Cited by 2

Molecular and Epidemiological Analysis of Carbapenem-Resistant Klebsiella pneumoniae in a Greek Tertiary Hospital: A Retrospective Study

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Characterization of a bla KPC-3 -carrying plasmid in a clinical isolate of Klebsiella pneumoniae belonging to the emerging successful clone ST147

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First report of ceftazidime-avibactam resistance in non-mutated blaKPC-3 K. pneumoniae recovered from patients with no prior treatment, in Latin America

Mott, M. P., Moreira, N. K., Collar, G. D. S., Scalco, S., Martins, J. B., Vieira, P., Pereira, D., de Oliveira, G. S., Martins, A., Barth, A. L., et al. (2025) · Diagnostic Microbiology and Infectious Disease · doi:10.1016/j.diagmicrobio.2025.116965 · Cited by 2

Synergistic Activity of Temocillin and Fosfomycin Combination against KPC-Producing Klebsiella pneumoniae Clinical Isolates

Costantino, V., Principe, L., Mehat, J. W., Busetti, M., Piccirilli, A., Perilli, M., Luzzati, R., Zerbato, V., Meliadò, A., Ragione, R. M. L., et al. (2024) · Antibiotics · doi:10.3390/antibiotics13060526 · Cited by 2

Elucidating adaptive compensatory tigecycline resistance mechanisms of RamA, RarA and SoxS in Klebsiella pneumoniae

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A letter to CLSI and EUCAST

Guo, Y., & Hu, F. (2025) · International Journal of Antimicrobial Agents · doi:10.1016/j.ijantimicag.2025.107549 · Cited by 1

Identification of two KPC variants, KPC-204 and KPC-227, in ST11-K64 Klebsiella pneumoniae during prolonged hospitalization of a single patient

Sun, S., Zhou, C., Li, H., Sun, L., Qi, S., Liu, X., & Wang, W. (2025) · Frontiers in Microbiology · doi:10.3389/fmicb.2025.1543470 · Cited by 1

In vitro activity of the novel β-lactamase inhibitor FL058 combined with meropenem against KPC- or NDM-producing enterobacterales and Pseudomonas aeruginosa

Yang, F., Yang, Y., Wu, S., Tang, C., Yin, D., Guo, Y., Zhu, D., & Hu, F. (2025) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-025-05232-3 · Cited by 2

Genomic Characterization of Multidrug-Resistant and ESBL-Producing Klebsiella pneumoniae Isolated from Healthy Rabbits Intended for Human Consumption

SILVA, V. Y. N. E. D., Caniça, M., de la Rivière, R., Silva, A. A. D. O., Poeta, P. A. C. Q. D., & Igrejas, G. (2025) · Microorganisms · doi:10.3390/microorganisms13081931 · Cited by 1

Regional Genomic and Phylogenomic Insights into Multidrug and Colistin-Resistant Klebsiella pneumoniae Strains from Tanzania, Kenya, Uganda, and Ethiopia

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Combined disk-based tests for phenotypic identification of KPC variants in Enterobacterales

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DOT-MGA for rapid determination of susceptibility to the combination of Ceftazidime-avibactam and Aztreonam among Enterobacterales

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First report of an Escherichia coli ST131 clinical isolate co-harboring bla KPC-2 and bla NDM-13 on an IncB/O/K/Z plasmid in China

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Phylogenetic diversification and fitness trade-offs of TetA variants in mediating eravacycline resistance in Klebsiella pneumoniae

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Comparative Genomic and Resistance Analysis of ST859-KL19 and ST11 Carbapenem-Resistant Klebsiella pneumoniae with Diverse Capsular Serotypes

Wang, X., Feng, J., Zhang, Y., Qiu, Y., Yang, B., Liang, Y., Wang, Y., Zhao, B., & Ren, L. (2026) · Antibiotics · doi:10.3390/antibiotics15010040 · Cited by 1

Identification of KPC-271, a novel KPC variant conferring ceftazidime-avibactam resistance while restoring carbapenem susceptibility in ST15-KL19 Klebsiella pneumoniae

Ou, H., Shen, S., Tang, C., Yang, W., Han, R., & Hu, F. (2026) · International Journal of Antimicrobial Agents · doi:10.1016/j.ijantimicag.2026.107725 · Cited by 1

Targeting carbapenem-resistant and hypervirulent Klebsiella pneumoniae: in vitro evaluation of cefepime/zidebactam, aztreonam/avibactam, imipenem/relebactam, and meropenem/vaborbactam

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Fluorescence-based high-throughput screening of carbapenemase inhibitors to enhance the antibacterial efficacy of antibiotics against carbapenem-resistant Klebsiella pneumoniae

Zhu, L., Wang, Y., Zhang, X., Ma, X., Yan, F., Feng, L., & Ma, T. (2026) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2026.139818 · Cited by 1

Differential analysis of virulence and antibiotic resistance genes in ST11 CRKP and ST15 CRKP isolates from a tertiary hospital

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Pharmacological approaches to overcome antimicrobial resistance in gram-negative bacterial infections: current practice and future directions

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Prediction of KPC-producing Klebsiella pneumoniae by MALDI-TOF MS, ensemble learning, and spectral peak annotation

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Molecular epidemiology of antimicrobial resistance and virulence of carbapenem-resistant Klebsiella pneumoniae in South China

He, Y., Deng, R., Lin, W., Yang, X., Li, Y., Yang, Y., Chen, C., & Huang, B. (2026) · Frontiers in Microbiology · doi:10.3389/fmicb.2026.1817833 · Cited by 1

Aggressive joint pharmacokinetic/pharmacodynamic target attainment of TDM-guided continuous infusion meropenem-vaborbactam monotherapy: A valuable strategy for maximizing the microbiological outcome of documented KPC-producing Enterobacterales infections?

Gatti, M., Bonazzetti, C., Secci, B., Giorgi, B., Rinaldi, M., Cojutti, P. G., Ambretti, S., Siniscalchi, A., Tonetti, T., Viale, P., et al. (2026) · International Journal of Antimicrobial Agents · doi:10.1016/j.ijantimicag.2026.107811 · Cited by 1

Risk factors for in vivo emergence of ceftazidime-avibactam resistance in KPC-producing Klebsiella pneumoniae and the associated resistance mechanisms: a case-control study

Chuang, C., Liu, S. M., Ho, Y.-C., Chou, S.-H., Huang, Y., Chin, W., Ho, H., Chen, L., & Lin, Y. (2026) · Microbiology Spectrum · doi:10.1128/spectrum.00972-26 · Cited by 1

Design and evaluation of a bifunctional fusion polypeptide for targeted delivery of tigecycline against drug-resistant Klebsiella pneumoniae

Zhou, M., Yao, Y., Ma, S., Chen, Y., Abudushalamu, G., Chen, D., Li, X., Tao, Y., Hou, Y., Gao, X., et al. (2026) · Journal of Nanobiotechnology · doi:10.1186/s12951-026-04497-w · Cited by 1

Stepwise KPC mutational accumulation confers high-level ceftazidime–avibactam resistance in ST11 carbapenem-resistant Klebsiella pneumoniae

Huang, H., Zhou, L., Xu, H., Liu, Q., Wang, L., Han, X., He, J., & Zhou, H. (2026) · Drug Resistance Updates · doi:10.1016/j.drup.2026.101420 · Cited by 1

Determinants of Carbapenem-Resistant Klebsiella pneumoniae: Clinical Outcomes and Epidemiological Risk Factors in a Single-Center Cohort Dataset

Penea, C. A.-M. O., Melinte, V., Cambrea, S. C., Holban, T. S., Radu, A. M., Văcăroiu, C. M., & Gheorghiţă, V. (2026) · Antibiotics · doi:10.3390/antibiotics15060621 · Cited by 1

Molecular Epidemiology of Klebsiella pneumoniae Based on Whole-Genome Sequencing Among Hospitalized Patients in Huzhou, China: A 6-Year Surveillance Study, 2020–2025

Ji, L., Zhang, P., Zha, Y., Dong, F., & Yan, W. (2026) · Microorganisms · doi:10.3390/microorganisms14071498 · Cited by 1

Resistance development in KPC-producing Klebsiella pneumoniae under ceftazidime/avibactam-meropenem pressure: KPC-2 Ω-loop mutations attenuate avibactam efficacy

Li, F.-H., Zheng, M., Zhong, G.-M., He, X.-M., Hu, M.-Z., Kuang, X., Wu, J.-J., Li, C.-M., Wang, J.-N., Zhou, X., et al. (2026) · Microbiology Spectrum · doi:10.1128/spectrum.00356-26 · Cited by 1

Epidemiology of KPC-producing Enterobacterales isolated from 2019 to 2023 in France

Rouabah, L., Ronsin, S., Vasseur, A., Rezzoug, I., Bernabeu, S., Birer, A., Emeraud, C., Naas, T., Bonnin, R. A., Dortet, L., et al. (2026) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkag273 · Cited by 1

The 2025 CHINET surveillance report on bacterial resistance in China

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KPC-85, a carbapenemase-producing and ceftazidime-avibactam-resistant KPC-3 variant found in Klebsiella pneumoniae ST512 in the Netherlands

Jamin, C., Notermans, D. W., Beuken, E. V. H., Maat, I., Lansu, S., Witteveen, S., Landman, F., van Alphen, L. B., Oteo, J., Carattoli, A., et al. (2024) · International Journal of Antimicrobial Agents · doi:10.1016/j.ijantimicag.2024.107271 · Cited by 1

Synergistic Effect of Ceftazidime-Avibactam with Aztreonam on Carbapenemase-Positive Klebsiella pneumoniae MBL+, NDM+ [Response to Letter]

Szymański, M., Skiba, M. M., & Piasecka, M. (2024) · Infection and Drug Resistance · doi:10.2147/idr.s486223 · Cited by 1

Reversion of KPC-114 to KPC-2 in ceftazidime-avibactam- resistant/meropenem-susceptible Klebsiella pneumoniae ST11 is related to low mutation rates

Pariona, J. G. M., Vásquez‐Ponce, F., Becerra, J., Martins-Gonçalves, T., Pariona, E. M. M., Madueño, F. T., Esposito, F. R. D. S., de Lima, A. V., Sampaio, J. L. M., Galhardo, R. S., et al. (2024) · Microbiology Spectrum · doi:10.1128/spectrum.01173-24 · Cited by 1

Clinical epidemiology and prognostic factors in patients with KPC-producing K. pneumoniae infections: a retrospective cohort study

Feng, Q., Song, Y., & Ha, X. (2025) · Frontiers in Public Health · doi:10.3389/fpubh.2025.1668530 · Cited by 1

Antimicrobial Resistance Genotyping

Mostafa, H. H., & Simner, P. J. (2025) · doi:10.1002/9781683674597.ch5 · Cited by 1

Microbiological Quality of Coconut Water Sold in the Grande Vitória Region, Brazil, and Phenogenotypic Antimicrobial Resistance of Associated Enterobacteria

Peterle, V. M., Cardoso, J. A. B., Ferraz, C. M., Sousa, D. F. D., Pereira, N., Nassar, A. F. D. C., Castro, V., Mathias, L. A., Cardozo, M. V., & Rossi, G. A. M. (2024) · Microorganisms · doi:10.3390/microorganisms12091883

Mức độ nhạy cảm với kháng sinh mới imipenem/relebactam của các chủng Klebsiella pneumoniae và Pseudomonas aeruginosa kháng carbapenem

Nhung, P. H., & Anh, N. T. V. (2024) · Tạp chí Nghiên cứu Y học · doi:10.52852/tcncyh.v178i5.2388

Combating multidrug-resistant bacteria with nanostructured guanidine-based polymers

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Research Progress of Carbapenem-Resistant Hypervirulent Klebsiella pneumoniae

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Clonal transmission of a ceftazidime–avibactam-resistant hypervirulent Klebsiella pneumoniae KL64-ST11 strains harboring bla NDM-1 , bla KPC-2 , and ompk36 deletionPreprint

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Description of blaKPC-carrying Escherichia coli in patients from a Brazilian hospital over a 4-year period

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