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Cited by 263

The DOI matches its Crossref record; 251 of the 251 references it cites were found in a registry or an index.

Going Wild: Lessons from Naturally Occurring T-Lymphotropic Lentiviruses

Open access
VandeWoude, Sue, Apetrei, Cristian·2006·Clinical Microbiology Reviews

Abstract

SUMMARY: Over 40 nonhuman primate (NHP) species harbor species-specific simian immunodeficiency viruses (SIVs). Similarly, more than 20 species of nondomestic felids and African hyenids demonstrate seroreactivity against feline immunodeficiency virus (FIV) antigens. While it has been challenging to study the biological implications of nonfatal infections in natural populations, epidemiologic and clinical studies performed thus far have only rarely detected increased morbidity or impaired fecundity/survival of naturally infected SIV- or FIV-seropositive versus -seronegative animals. Cross-species transmissions of these agents are rare in nature but have been used to develop experimental systems to evaluate mechanisms of pathogenicity and to develop animal models of HIV/AIDS. Given that felids and primates are substantially evolutionarily removed yet demonstrate the same pattern of apparently nonpathogenic lentiviral infections, comparison of the biological behaviors of these viruses can yield important implications for host-lentiviral adaptation which are relevant to human HIV/AIDS infection. This review therefore evaluates similarities in epidemiology, lentiviral genotyping, pathogenicity, host immune responses, and cross-species transmission of FIVs and factors associated with the establishment of lentiviral infections in new species. This comparison of consistent patterns in lentivirus biology will expose new directions for scientific inquiry for understanding the basis for virulence versus avirulence.

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Metadata

Authors
VandeWoude, S., & Apetrei, C.
Venue
Clinical Microbiology Reviews
Published
2006-10
Volume
19
Issue
4
Pages
728-762
ISSN
  • 0893-8512 (ISSN-L)
  • 1098-6618
OpenAlex
W2128720756
Cited by
263
References
251
FWCI
6.23
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Going Wild: Lessons from Naturally Occurring T-Lymphotropic Lentiviruses. https://app.cochat.ai/papers/10.1128/cmr.00009-06
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VandeWoude, S., & Apetrei, C. (2006). Going Wild: Lessons from Naturally Occurring T-Lymphotropic Lentiviruses. Clinical Microbiology Reviews. https://doi.org/10.1128/cmr.00009-06

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