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Control of Viremia in Simian Immunodeficiency Virus Infection by CD8 + Lymphocytes
Abstract
Clinical evidence suggests that cellular immunity is involved in controlling human immunodeficiency virus–1 (HIV-1) replication. An animal model of acquired immune deficiency syndrome (AIDS), the simian immunodeficiency virus (SIV)–infected rhesus monkey, was used to show that virus replication is not controlled in monkeys depleted of CD8 + lymphocytes during primary SIV infection. Eliminating CD8 + lymphocytes from monkeys during chronic SIV infection resulted in a rapid and marked increase in viremia that was again suppressed coincident with the reappearance of SIV-specific CD8 + T cells. These results confirm the importance of cell-mediated immunity in controlling HIV-1 infection and support the exploration of vaccination approaches for preventing infection that will elicit these immune responses.
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Metadata
- Authors
- Schmitz, J. E., Kuroda, M. J., Santra, S., Sasseville, V. G., Simon, M. A., Lifton, M. A., Racz, P., Tenner-Racz, K., Dalesandro, M., Scallon, B. J., Ghrayeb, J., Forman, M. A., Montefiori, D. C., Rieber, E. P., Letvin, N. L., & Reimann, K. A.
- Venue
- Science
- Published
- 1999-02-05
- Volume
- 283
- Issue
- 5403
- Pages
- 857-860
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2144882745
- Cited by
- 2,187
- References
- 0
- FWCI
- 45.31
- Type
- journal article
- Language
- en
- Open access
- closed
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- Schmitz, J. E., Kuroda, M. J., Santra, S., Sasseville, V. G., Simon, M. A., Lifton, M. A., Racz, P., Tenner-Racz, K., Dalesandro, M., Scallon, B. J., Ghrayeb, J., Forman, M. A., Montefiori, D. C., Rieber, E. P., Letvin, N. L., & Reimann, K. A. (1999). Control of Viremia in Simian Immunodeficiency Virus Infection by CD8 + Lymphocytes. Science. https://doi.org/10.1126/science.283.5403.857
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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