Multiplexed Molecular Diagnostics for Respiratory, Gastrointestinal, and Central Nervous System Infections

Hanson, Kimberly E.; Couturier, Marc Roger

doi:10.1093/cid/ciw494

Cited by 99Bacterial Identification and Susceptibility TestingBiosensors and Analytical DetectionClinical Laboratory Practices and Quality Control

Multiplexed Molecular Diagnostics for Respiratory, Gastrointestinal, and Central Nervous System Infections

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Hanson, Kimberly E., Couturier, Marc Roger·2016·Clinical Infectious Diseases

DOI 10.1093/cid/ciw494PMC PMC5091344

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Abstract

The development and implementation of highly multiplexed molecular diagnostic tests have allowed clinical microbiology laboratories to more rapidly and sensitively detect a variety of pathogens directly in clinical specimens. Current US Food and Drug Administration-approved multiplex panels target multiple different organisms simultaneously and can identify the most common pathogens implicated in respiratory viral, gastrointestinal, or central nervous system infections. This review summarizes the test characteristics of available assays, highlights the advantages and limitations of multiplex technology for infectious diseases, and discusses potential utilization of these new tests in clinical practice.

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Authors: Hanson, K. E., & Couturier, M. R.
Affiliations: University of Utah (US)
Corresponding author: Hanson, Kimberly E.
ORCID: Hanson, Kimberly E.
Couturier, Marc Roger
Venue: Clinical Infectious Diseases
Publisher: Oxford University Press (OUP)
Published: 2016-07-20
Volume: 63
Issue: 10
Pages: 1361-1367
ISSN: 1058-4838 (ISSN-L)
1537-6591
DOI: 10.1093/cid/ciw494
PMC: PMC5091344
OpenAlex: W2504315498
Cited by: 99
References: 38
Citations by year: 2026: 10 · 2025: 10 · 2024: 6 · 2023: 8 · 2022: 6 · 2021: 11 · 2020: 10 · 2019: 13 · 2018: 15 · 2017: 9 · 2016: 1
FWCI: 1.30
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Clinical Infectious Diseases (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
HighWire Press Open Archive (submittedVersion)
Funders: National Institutes of Health
BioFire Dignostics, LLC (5R43AI104029-02, 5R01AI11703502)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Bacterial Identification and Susceptibility Testing
Physical Sciences › Engineering › Biomedical Engineering › Biosensors and Analytical Detection
Health Sciences › Medicine › Physiology › Clinical Laboratory Practices and Quality Control
Keywords: pathogen detection, respiratory viral infections, gastrointestinal infections, central nervous system infection, multiplex PCR panels, clinical microbiology laboratory, rapid pathogen detection
MeSH terms: Bacteria, Bacterial Infections, Central Nervous System Infections, Gastrointestinal Diseases, Humans, Respiratory Tract Infections, Virus Diseases, Viruses, Molecular Diagnostic Techniques

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Multiplexed Molecular Diagnostics for Respiratory, Gastrointestinal, and Central Nervous System Infections

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