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Polymyxins: Antibacterial Activity, Susceptibility Testing, and Resistance Mechanisms Encoded by Plasmids or Chromosomes

Open access
Poirel, Laurent, Jayol, Aurélie, Nordmann, Patrice·2017·Clinical Microbiology Reviews

Abstract

SUMMARY: Polymyxins are well-established antibiotics that have recently regained significant interest as a consequence of the increasing incidence of infections due to multidrug-resistant Gram-negative bacteria. Colistin and polymyxin B are being seriously reconsidered as last-resort antibiotics in many areas where multidrug resistance is observed in clinical medicine. In parallel, the heavy use of polymyxins in veterinary medicine is currently being reconsidered due to increased reports of polymyxin-resistant bacteria. Susceptibility testing is challenging with polymyxins, and currently available techniques are presented here. Genotypic and phenotypic methods that provide relevant information for diagnostic laboratories are presented. This review also presents recent works in relation to recently identified mechanisms of polymyxin resistance, including chromosomally encoded resistance traits as well as the recently identified plasmid-encoded polymyxin resistance determinant MCR-1. Epidemiological features summarizing the current knowledge in that field are presented.

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Metadata

Authors
Poirel, L., Jayol, A., & Nordmann, P.
Venue
Clinical Microbiology Reviews
Published
2017-04
Volume
30
Issue
2
Pages
557-596
ISSN
  • 0893-8512 (ISSN-L)
  • 1098-6618
OpenAlex
W2593444269
Cited by
1,447
References
5
FWCI
49.56
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Polymyxins: Antibacterial Activity, Susceptibility Testing, and Resistance Mechanisms Encoded by Plasmids or Chromosomes. https://app.cochat.ai/papers/10.1128/cmr.00064-16
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Poirel, L., Jayol, A., & Nordmann, P. (2017). Polymyxins: Antibacterial Activity, Susceptibility Testing, and Resistance Mechanisms Encoded by Plasmids or Chromosomes. Clinical Microbiology Reviews. https://doi.org/10.1128/cmr.00064-16

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Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.