The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Salmonella enterica Serovar Typhimurium Skills To Succeed in the Host: Virulence and Regulation
Open accessAbstract
SUMMARY: Salmonella enterica serovar Typhimurium is a primary enteric pathogen infecting both humans and animals. Infection begins with the ingestion of contaminated food or water so that salmonellae reach the intestinal epithelium and trigger gastrointestinal disease. In some patients the infection spreads upon invasion of the intestinal epithelium, internalization within phagocytes, and subsequent dissemination. In that case, antimicrobial therapy, based on fluoroquinolones and expanded-spectrum cephalosporins as the current drugs of choice, is indicated. To accomplish the pathogenic process, the Salmonella chromosome comprises several virulence mechanisms. The most important virulence genes are those located within the so-called Salmonella pathogenicity islands (SPIs). Thus far, five SPIs have been reported to have a major contribution to pathogenesis. Nonetheless, further virulence traits, such as the pSLT virulence plasmid, adhesins, flagella, and biofilm-related proteins, also contribute to success within the host. Several regulatory mechanisms which synchronize all these elements in order to guarantee bacterial survival have been described. These mechanisms govern the transitions from the different pathogenic stages and drive the pathogen to achieve maximal efficiency inside the host. This review focuses primarily on the virulence armamentarium of this pathogen and the extremely complicated regulatory network controlling its success.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Peroxynitrite: biochemistry, pathophysiology and development of therapeutics
Szabó, C., Ischiropoulos, H., & Radi, R. (2007) · Nature Reviews Drug Discovery · doi:10.1038/nrd2222 · Cited by 2,134
Seng, P., Drancourt, M., Gouriet, F., La Scola, B., Fournier, P., Rolain, J. M., & Raoult, D. (2009) · Clinical Infectious Diseases · doi:10.1086/600885 · Cited by 1,983 · cited 1×
“Unfortunately, the identification of Salmonella clinical isolates with MALDI-TOF analysis cannot reach the serovar level (23, 24).”
BackgroundFranchi, L., Amer, A., Body-Malapel, M., Kanneganti, T.-D., Özören, N., Jagirdar, R., Inohara, N., Vandenabeele, P., Bertin, J., Coyle, A., et al. (2006) · Nature Immunology · doi:10.1038/ni1346 · Cited by 1,131
Cytoplasmic flagellin activates caspase-1 and secretion of interleukin 1β via Ipaf
Miao, E. A., Alpuche-Aranda, C. M., Dors, M., Clark, A. E., Bader, M. W., Miller, S. I., & Aderem, A. (2006) · Nature Immunology · doi:10.1038/ni1344 · Cited by 1,127 · cited 1×
“Moreover, in addition to activating TLR5 in the basolateral membrane, flagellin can also be recognized by the cytosolic mammalian molecule IPAF, a protease that transmits a proinflammatory signal to activate the inflammasome, eventually triggering rapid macrophage pyroptosis (197, 198).”
BackgroundParry, C. M., Hien, T. T., Dougan, G., White, N. J., & Farrar, J. J. (2002) · New England Journal of Medicine · doi:10.1056/nejmra020201 · Cited by 1,112
Stecher, B., Robbiani, R., Walker, A. W., Westendorf, A. M., Barthel, M., Kremer, M., Chaffron, S., Macpherson, A. J., Buer, J., Parkhill, J., et al. (2007) · PLoS Biology · doi:10.1371/journal.pbio.0050244 · Cited by 1,048
Salmonella, the host and disease: a brief review
Coburn, B., Grassl, G. A., & Finlay, B. B. (2007) · Immunology & Cell Biology · doi:10.1038/sj.icb.7100007 · Cited by 690
Identification of a Salmonella typhimurium invasion locus by selection for hyperinvasive mutants
Lee, C. A., Jones, B. D., & Falkow, S. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.5.1847 · Cited by 296
QseC Mediates Salmonella enterica Serovar Typhimurium Virulence In Vitro and In Vivo
Moreira, C. G., Weinshenker, D., & Sperandio, V. (2010) · Infection and Immunity · doi:10.1128/iai.01038-09 · Cited by 195
Troxell, B., Sikes, M. L., Fink, R. C., Vazquez-Torres, A., Jones-Carson, J., & Hassan, H. M. (2011) · Journal of Bacteriology · doi:10.1128/jb.00942-10 · Cited by 99 · cited 1×
“have given new insight into this by showing that Fur binds to the promoter of the hns gene (323).”
Background
Cited by
Functions of ROS in Macrophages and Antimicrobial Immunity
Herb, M., & Schramm, M. (2021) · Antioxidants · doi:10.3390/antiox10020313 · Cited by 633
The scanning electron microscope in microbiology and diagnosis of infectious disease
Golding, C. G., Lamboo, L. L., Beniac, D. R., & Booth, T. F. (2016) · Scientific Reports · doi:10.1038/srep26516 · Cited by 236
Genetic control of bacterial biofilms
Wolska, K. I., Grudniak, A. M., Rudnicka, Z., & Markowska, K. (2016) · Journal of Applied Genetics · doi:10.1007/s13353-015-0309-2 · Cited by 154
Ke, Y., Lu, W., Liu, W., Zhu, P., Chen, Q., & Zhu, Z. (2020) · PLOS Neglected Tropical Diseases · doi:10.1371/journal.pntd.0008732 · Cited by 38
Argandoña, Y., Olivos, A., Obando, P., Imas, F., Pohl, E., Quatrini, R., & Arenas-Salinas, M. (2025) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2025.02.017 · Cited by 3
Metadata
- Authors
- Fàbrega, A., & Vila, J.
- Venue
- Clinical Microbiology Reviews
- Publisher
- American Society for Microbiology
- Published
- 2013-04
- Volume
- 26
- Issue
- 2
- Pages
- 308-341
- ISSN
- 0893-8512 (ISSN-L)
- 1098-6618
- OpenAlex
- W2122343132
- Cited by
- 821
- References
- 11
- FWCI
- 59.03
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
