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Cited by 325Antimicrobial Resistance in StaphylococcusBacterial biofilms and quorum sensingBacterial Genetics and Biotechnology

The DOI matches its Crossref record; 223 of the 223 references it cites were found in a registry or an index.

Clinical Significance and Pathogenesis of Staphylococcal Small Colony Variants in Persistent Infections

Open access
Kahl, Barbara C., Becker, Karsten, Löffler, Bettina·2016·Clinical Microbiology Reviews
DOI 10.1128/cmr.00069-15PMC PMC4786882
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Abstract

SUMMARY: Small colony variants (SCVs) were first described more than 100 years ago for Staphylococcus aureus and various coagulase-negative staphylococci. Two decades ago, an association between chronic staphylococcal infections and the presence of SCVs was observed. Since then, many clinical studies and observations have been published which tie recurrent, persistent staphylococcal infections, including device-associated infections, bone and tissue infections, and airway infections of cystic fibrosis patients, to this special phenotype. By their intracellular lifestyle, SCVs exhibit so-called phenotypic (or functional) resistance beyond the classical resistance mechanisms, and they can often be retrieved from therapy-refractory courses of infection. In this review, the various clinical infections where SCVs can be expected and isolated, diagnostic procedures for optimized species confirmation, and the pathogenesis of SCVs, including defined underlying molecular mechanisms and the phenotype switch phenomenon, are presented. Moreover, relevant animal models and suggested treatment regimens, as well as the requirements for future research areas, are highlighted.

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Crossref · 10.1128/cmr.00069-15

Cites

223 of 223 references verified0 citation errors · 0 not checkable

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Citations

Cites

Items 201–223 of 223

Research works printed but not linked: 5

  1. Borderon E , Horodniceanu T . 1976. Mutants déficients a colonies naines de Staphylococcus: étude de trois souches isolées chez des malades porteurs d'ostéosynthèses. Ann Microbiol (Paris) 127:503–514.
  2. Cystic Fibrosis Foundation. 2013. Cystic Fibrosis Foundation annual report 2013. Cystic Fibrosis Foundation, Bethesda, MD.
  3. Zolin A , van Rens J , Fox A , Iansa P , Preftitsi A , Pypops U , Gulmans V , Jung A , Mehta A , Viviani L , Vebert Olesen H , McKone E . 2014. ECFS Patient Registry, annual report 2010. European Cystic Fibrosis Society, Karup, Denmark.
  4. Stryer L . 1995. Biosynthesis of nucleotides, p 736–762. In Stryer L (ed), Biochemistry, 4th ed. W H Freeman, New York, NY.
  5. Coman G , Mardare N , Copacianu B , Covic M . 2008. Infectie cutanata persistenta si recurenta cu Staphyloccocus aureus meticilino-rezistent, varianta cu colonii mici. Rev Med Chir Soc Med Nat Iasi 112:104–107.

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Metadata

Authors
Kahl, B. C., Becker, K., & Löffler, B.
Affiliations
  • University Hospital Münster (DE)
  • Jena University Hospital (DE)
ORCID
Venue
Clinical Microbiology Reviews
Publisher
American Society for Microbiology
Published
2016-04
Volume
29
Issue
2
Pages
401-427
ISSN
  • 0893-8512 (ISSN-L)
  • 1098-6618
DOI
10.1128/cmr.00069-15
PMC
PMC4786882
OpenAlex
W2293222550
Cited by
325
References
223
Citations by year
2026: 24 · 2025: 28 · 2024: 35 · 2023: 39 · 2022: 29 · 2021: 44 · 2020: 47 · 2019: 34 · 2018: 21 · 2017: 19 · 2016: 5
FWCI
4.05
Type
journal article
Language
en
Open access
Licence
journals.asm.org/non-commercial-tdm-license (tdm)
Locations
  • Clinical Microbiology Reviews (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Infectious Diseases › Antimicrobial Resistance in Staphylococcus
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
Keywords
small colony variants, Staphylococcus aureus, coagulase-negative staphylococci, device-related infection, phenotypic antibiotic resistance, intracellular lifestyle, phenotypic switching, species identification, pathogenesis, animal models, treatment regimens
MeSH terms
Animals, Cross Infection, Disease Models, Animal, Humans, Phenotype, Staphylococcal Infections, Staphylococcus aureus, Bacterial Typing Techniques

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