Selective pressures during chronic infection drive microbial competition and cooperation
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Chronic infections often contain complex mixtures of pathogenic and commensal microorganisms ranging from aerobic and anaerobic bacteria to fungi and viruses. The microbial communities present in infected tissues are not passively co-existing but rather actively interacting with each other via a spectrum of competitive and/or cooperative mechanisms. Competition versus cooperation in these microbial interactions can be driven by both the composition of the microbial community as well as the presence of host defense strategies. These interactions are typically mediated via the production of secreted molecules. In this review, we will explore the possibility that microorganisms competing for nutrients at the host–pathogen interface can evolve seemingly cooperative mechanisms by controlling the production of subsets of secreted virulence factors. We will also address interspecies versus intraspecies utilization of community resources and discuss the impact that this phenomenon might have on co-evolution at the host–pathogen interface.
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Such adaptations help these strains better compete for limited resources and interact with the host's resident microbiome.
“Such adaptations help these strains better compete for limited resources and interact with the host’s resident microbiome.21,22”
From Gut microbiota drives structural variation of exogenous probiotics to enhance colonization (2025) · cites this paper as [22]
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- Authors
- Baishya, J., & Wakeman, C. A.
- Affiliations
- Texas Tech University (US)
- Corresponding author
- Wakeman, Catherine A.
- Venue
- npj Biofilms and Microbiomes
- Published
- 2019-06-07
- Volume
- 5
- Issue
- 1
- Pages
- 16-16
- ISSN
- 2055-5008 (ISSN-L)
- PMC
- PMC6555799
- OpenAlex
- W2948564536
- Cited by
- 70
- References
- 120
- Citations by year
- 2026: 12 · 2025: 9 · 2024: 7 · 2023: 13 · 2022: 10 · 2021: 10 · 2020: 8 · 2019: 1
- FWCI
- 0.66
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- npj Biofilms and Microbiomes (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- ThinkTech (Texas Tech University) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (R15GM128072)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
- Keywords
- chronic infection, microbial competition, microbial cooperation, host-pathogen interface, commensal microorganisms, secreted virulence factors, coevolution, microbial interactions
- MeSH terms
- Humans, Selection, Genetic, Host-Pathogen Interactions, Microbial Interactions, Coinfection, Microbiota
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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