Cited by 71Bacterial biofilms and quorum sensingGut microbiota and healthEvolution and Genetic Dynamics

Selective pressures during chronic infection drive microbial competition and cooperation

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Baishya, Jiwasmika, Wakeman, Catherine A.·2019·npj Biofilms and Microbiomes

Abstract

Chronic infections often contain complex mixtures of pathogenic and commensal microorganisms ranging from aerobic and anaerobic bacteria to fungi and viruses. The microbial communities present in infected tissues are not passively co-existing but rather actively interacting with each other via a spectrum of competitive and/or cooperative mechanisms. Competition versus cooperation in these microbial interactions can be driven by both the composition of the microbial community as well as the presence of host defense strategies. These interactions are typically mediated via the production of secreted molecules. In this review, we will explore the possibility that microorganisms competing for nutrients at the host–pathogen interface can evolve seemingly cooperative mechanisms by controlling the production of subsets of secreted virulence factors. We will also address interspecies versus intraspecies utilization of community resources and discuss the impact that this phenomenon might have on co-evolution at the host–pathogen interface.

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Authors
Baishya, J., & Wakeman, C. A.
Affiliations
Texas Tech University (US)
Corresponding author
Wakeman, Catherine A.
Venue
npj Biofilms and Microbiomes
Published
2019-06-07
Volume
5
Issue
1
Pages
16-16
ISSN
2055-5008 (ISSN-L)
OpenAlex
W2948564536
Cited by
70
References
120
Citations by year
2026: 12 · 2025: 9 · 2024: 7 · 2023: 13 · 2022: 10 · 2021: 10 · 2020: 8 · 2019: 1
FWCI
0.66
Type
journal article
Language
en
Open access
Locations
  • npj Biofilms and Microbiomes (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • ThinkTech (Texas Tech University) (submittedVersion, cc-by)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders
U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (R15GM128072)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
Keywords
chronic infection, microbial competition, microbial cooperation, host-pathogen interface, commensal microorganisms, secreted virulence factors, coevolution, microbial interactions
MeSH terms
Humans, Selection, Genetic, Host-Pathogen Interactions, Microbial Interactions, Coinfection, Microbiota

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