The DOI matches its Crossref record; 223 of the 223 references it cites were found in a registry or an index.
Clinical Significance and Pathogenesis of Staphylococcal Small Colony Variants in Persistent Infections
Open accessAbstract
SUMMARY: Small colony variants (SCVs) were first described more than 100 years ago for Staphylococcus aureus and various coagulase-negative staphylococci. Two decades ago, an association between chronic staphylococcal infections and the presence of SCVs was observed. Since then, many clinical studies and observations have been published which tie recurrent, persistent staphylococcal infections, including device-associated infections, bone and tissue infections, and airway infections of cystic fibrosis patients, to this special phenotype. By their intracellular lifestyle, SCVs exhibit so-called phenotypic (or functional) resistance beyond the classical resistance mechanisms, and they can often be retrieved from therapy-refractory courses of infection. In this review, the various clinical infections where SCVs can be expected and isolated, diagnostic procedures for optimized species confirmation, and the pathogenesis of SCVs, including defined underlying molecular mechanisms and the phenotype switch phenomenon, are presented. Moreover, relevant animal models and suggested treatment regimens, as well as the requirements for future research areas, are highlighted.
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“petites can also be presented as a mixture of small (petite) and large (non-petite) colonies (4).”
From Overlooked Candida glabrata petites are echinocandin tolerant, induce host inflammatory responses, and display poor in vivo fitness (2023) · cites this paper as [4]
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“Bacteria can adopt various phenotypes, such as SCV (1, 4, 8) and antibiotic tolerant and persister cells (34), which are not effectively killed by cidal antibiotics or by other host-related stresses.”
BackgroundInfluential
Metadata
- Authors
- Kahl, B. C., Becker, K., & Löffler, B.
- Affiliations
- University Hospital Münster (DE)
- Jena University Hospital (DE)
- Venue
- Clinical Microbiology Reviews
- Publisher
- American Society for Microbiology
- Published
- 2016-04
- Volume
- 29
- Issue
- 2
- Pages
- 401-427
- ISSN
- 0893-8512 (ISSN-L)
- 1098-6618
- PMC
- PMC4786882
- OpenAlex
- W2293222550
- Cited by
- 325
- References
- 223
- Citations by year
- 2026: 24 · 2025: 28 · 2024: 35 · 2023: 39 · 2022: 29 · 2021: 44 · 2020: 47 · 2019: 34 · 2018: 21 · 2017: 19 · 2016: 5
- FWCI
- 4.05
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Clinical Microbiology Reviews (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antimicrobial Resistance in Staphylococcus
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Keywords
- small colony variants, Staphylococcus aureus, coagulase-negative staphylococci, device-related infection, phenotypic antibiotic resistance, intracellular lifestyle, phenotypic switching, species identification, pathogenesis, animal models, treatment regimens
- MeSH terms
- Animals, Cross Infection, Disease Models, Animal, Humans, Phenotype, Staphylococcal Infections, Staphylococcus aureus, Bacterial Typing Techniques
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