The DOI matches its Crossref record; 95 of the 95 references it cites were found in a registry or an index.
Methicillin-resistant staphylococci
Open accessAbstract
Strains of staphylococci resistant to methicillin were identified immediately after introduction of this drug. Methicillin-resistant strains have unusual properties, the most notable of which is extreme variability in expression of the resistance trait. The conditions associated with this heterogeneous expression of resistance are described. Methicillin resistance is associated with production of a unique penicillin-binding protein (PBP), 2a, which is bound and inactivated only at high concentrations of beta-lactam antibiotics. PBP2a appears to be encoded by the mec determinant, which also is unique to methicillin-resistant strains. The relationships between PBP2a and expression of resistance and implications for the mechanism of resistance are discussed. The heterogeneous expression of methicillin resistance by staphylococci poses problems in the detection of resistant strains. Experience with several susceptibility test methods is reviewed and guidelines for performance of these tests are given. Treatment of infections caused by methicillin-resistant staphylococci is discussed. Vancomycin is the treatment of choice. Alternatives have been few because methicillin-resistant strains often are resistant to multiple antibiotics in addition to beta-lactam antibiotics. New agents which are active against methicillin-resistant staphylococci are becoming available, and their potential role in treatment is discussed.
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Cites
National Committee for Clinical Laboratory Standards
Bruck, E. (1980) · Pediatrics · doi:10.1542/peds.65.1.187 · Cited by 14,751
Hartman, B. J., & Tomasz, A. (1984) · Journal of Bacteriology · doi:10.1128/jb.158.2.513-516.1984 · Cited by 890
Methicillin-resistant staphylococci
Barber, M. (1961) · Journal of Clinical Pathology · doi:10.1136/jcp.14.4.385 · Cited by 729
PENICILLIN-BINDING PROTEINS AND THE MECHANISM OF ACTION OF BETA-LACTAM ANTIBIOTICS
Waxman, D. J., & Strominger, J. L. (1983) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.52.070183.004141 · Cited by 721
Antimicrobial resistance of Staphylococcus aureus: genetic basis
Lyon, B. R., & Skurray, R. A. (1987) · Microbiological Reviews · doi:10.1128/mmbr.51.1.88-134.1987 · Cited by 686
Epidemiology of Nosocomial Infections Caused by Methicillin-Resistant Staphylococcus aureus
THOMPSON, R. L., CABEZUDO, I., & WENZEL, R. P. (1982) · Annals of Internal Medicine · doi:10.7326/0003-4819-97-3-309 · Cited by 651
Emergence of Vancomycin Resistance in Coagulase-Negative Staphylococci
Schwalbe, R. S., Stapleton, J. T., & Gilligan, P. H. (1987) · New England Journal of Medicine · doi:10.1056/nejm198704093161507 · Cited by 584
Barrett, F. F., McGehee, R. F., & Finland, M. (1968) · New England Journal of Medicine · doi:10.1056/nejm196808292790901 · Cited by 512
HALEY, R. W., HIGHTOWER, A. W., KHABBAZ, R. F., THORNSBERRY, C., MARTONE, W. J., ALLEN, J. R., & HUGHES, J. M. (1982) · Annals of Internal Medicine · doi:10.7326/0003-4819-97-3-297 · Cited by 404
KARCHMER, A. W., ARCHER, G. L., & DISMUKES, W. E. (1983) · Annals of Internal Medicine · doi:10.7326/0003-4819-98-4-447 · Cited by 395
Cited by
Wiegand, I., Hilpert, K., & Hancock, R. E. W. (2008) · Nature Protocols · doi:10.1038/nprot.2007.521 · Cited by 6,156
The crisis in antibiotic resistance
Neu, H. C. (1992) · Science · doi:10.1126/science.257.5073.1064 · Cited by 2,834
Lucet, J. C., Herrmann, M., Rohner, P., Auckenthaler, R., Waldvogel, F. A., & Lew, D. P. (1990) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.34.12.2312 · Cited by 142
Metadata
- Authors
- Chambers, H. F.
- Venue
- Clinical Microbiology Reviews
- Publisher
- American Society for Microbiology
- Published
- 1988-04
- Volume
- 1
- Issue
- 2
- Pages
- 173-186
- ISSN
- 0893-8512 (ISSN-L)
- 1098-6618
- OpenAlex
- W1876295475
- Cited by
- 274
- References
- 95
- FWCI
- 11.51
- Type
- journal article
- Language
- en
- Open access
- bronze
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
