PENICILLIN-BINDING PROTEINS AND THE MECHANISM OF ACTION OF BETA-LACTAM ANTIBIOTICS
Abstract
The Hippo pathway was initially discovered in Drosophila melanogaster as a key regulator of tissue growth. It is an evolutionarily conserved signaling cascade regulating numerous biological processes, including cell growth and fate decision, organ size ...Read More
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Streptomycin was the first aminoglycoside antibiotic and the first effective treatment for tuberculosis; tetracycline provided broad-spectrum activity; chloramphenicol was effective against typhoid fever and meningitis.
“Among the most impactful were streptomycin, the first aminoglycoside antibiotic and the first effective treatment for tuberculosis [11]; tetracycline, which provided broad-spectrum activity against Gram-positive and Gram-negative organisms; and chloramphenicol, a powerful agent effective against life-threatening infections such as typhoid fever and meningitis [12].”
From The penicillin revolution and the role of the forgotten pioneer Vincenzo Tiberio (1869-1915): discovery, development and legacy. (2025) · cites this paper as [12]
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Ton-That, H., Liu, G., Mazmanian, S. K., Faull, K. F., & Schneewind, O. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.22.12424 · Cited by 567 · see citing works
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Varotto, E., Galassi, F. M., Martini, M., Gallitto, L., & Ingaliso, L. (2025) · Journal of Preventive Medicine and Hygiene · doi:10.15167/2421-4248/jpmh2025.66.2.3647
- Authors
- Waxman, D. J., & Strominger, J. L.
- Venue
- Annual Review of Biochemistry
- Publisher
- Annual Reviews
- Published
- 1983-06
- Volume
- 52
- Issue
- 1
- Pages
- 825-869
- ISSN
- 0066-4154
- 1545-4509
- Cited by
- 593
- References
- 0
- Language
- ps
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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