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Cited by 317Cytokine Signaling Pathways and InteractionsImmune Response and InflammationChemokine receptors and signaling

A primer on cytokines: sources, receptors, effects, and inducers

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Curfs, J H, Meis, J F, Hoogkamp-Korstanje, J A·1997·Clinical Microbiology Reviews
DOI 10.1128/cmr.10.4.742PMC PMC172943
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Abstract

Protection against pathogens is a prerequisite for survival of most organisms. To cope with this continuous challenge, complex defense mechanisms have evolved. The construction, adaptation, and maintenance of these mechanisms are under control of an extensive network of regulatory proteins called cytokines. A great number of cytokines have been described over the last 2 decades. This review consists of an overview of cytokines that are involved in immune responses and describes some historical and general aspects as well as prospective clinical applications. Major biological effects together with information on cytokine receptors, producers, inducers, and biochemical and molecular characteristics are listed in tables. In addition, some basic information is given on cytokine receptor signal transduction. Finally, the recent discoveries of cytokine receptors functioning as coreceptors in the pathogenesis of human immunodeficiency virus are summarized.

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Authors
Curfs, J. H., Meis, J. F., & Hoogkamp-Korstanje, J. A.
Affiliations
Department of Medical Microbiology, University Hospital Nijmegen, The Netherlands. J.CURFS@MMB.AZN.NL
Corresponding author
  • Curfs, J H
  • Meis, J F
  • Hoogkamp-Korstanje, J A
Venue
Clinical Microbiology Reviews
Publisher
American Society for Microbiology
Published
1997-10
Volume
10
Issue
4
Pages
742-780
ISSN
  • 0893-8512 (ISSN-L)
  • 1098-6618
DOI
10.1128/cmr.10.4.742
PMC
PMC172943
OpenAlex
W2135213970
Cited by
317
References
213
Citations by year
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FWCI
4.87
Type
journal article
Language
en
Open access
Licence
journals.asm.org/non-commercial-tdm-license (tdm)
Locations
  • Clinical Microbiology Reviews (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • Radboud Repository (Radboud University) (submittedVersion)
Topics
  • Health Sciences › Medicine › Oncology › Cytokine Signaling Pathways and Interactions
  • Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
  • Health Sciences › Medicine › Oncology › Chemokine receptors and signaling
Keywords
cytokines, cytokine receptors, cytokine signaling, immune response, pathogen defense, HIV co-receptor
MeSH terms
Colony-Stimulating Factors, Interferons, Interleukins, Tumor Necrosis Factor-alpha, Signal Transduction, HIV Infections, Cytokines, Receptors, Cytokine, Chemokines

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