Interleukin-6: an overview

Van Snick, Jacques

doi:10.1146/annurev.iy.08.040190.001345

Cited by 1,890Cytokine Signaling Pathways and InteractionsT-cell and B-cell ImmunologyRheumatoid Arthritis Research and Therapies

Interleukin-6: an overview

Van Snick, Jacques·1990·Annual Review of Immunology

DOI 10.1146/annurev.iy.08.040190.001345

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IL-6 is a pleiotropic cytokine involved in immune responses, inflammation, hematopoiesis, bone metabolism, embryonic development and other fundamental processes.
“IL-6, which was discovered in 1986 (27), is a pleiotropic cytokine involved not only in immune responses but also in inflammation, hematopoiesis, bone metabolism, embryonic development and other fundamental processes (1, 21, 28–32).”
From IL-6 in inflammation, autoimmunity and cancer (2021) · cites this paper as [28]
IL-6 is a growth factor for plasmacytoma and myeloma.
“Taking the above together with the fact that IL-6 is a growth factor for plasmacytoma and myeloma (28, 37)”
From IL-6 in inflammation, autoimmunity and cancer (2021) · cites this paper as [28]

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“IL-6, which was originally identified as a B cell differentiation factor (13, 14), is now known to be a multifunctional cytokine that regulates the immune response, hematopoiesis, the acute phase response, and inflammation (4, 15).”
Background
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Interleukin-6 Production Does Not Increase With Age
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“IL-6 is a pleiotropic cytokine that plays a major role in the host's response to injury or infection (Snick, 1990).”
Background
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Authors: Van Snick, J.
Venue: Annual Review of Immunology
Publisher: Annual Reviews
Published: 1990-04
Volume: 8
Issue: 1
Pages: 253-278
ISSN: 0732-0582 (ISSN-L)
1545-3278
DOI: 10.1146/annurev.iy.08.040190.001345
OpenAlex: W2135392289
Cited by: 1,890
References: 1
Citations by year: 2026: 7 · 2025: 14 · 2024: 15 · 2023: 17 · 2022: 19 · 2021: 26 · 2020: 13 · 2019: 23 · 2018: 20 · 2017: 24 · 2016: 27 · 2015: 34 · 2014: 35 · 2013: 36 · 2012: 40
FWCI: 47.76
Type: journal article
Language: en
Open access: closed
Locations: Annual Review of Immunology (publishedVersion)
PubMed (publishedVersion)
Digital Access to Libraries (submittedVersion)
Annual Review of Genetics
Topics: Health Sciences › Medicine › Oncology › Cytokine Signaling Pathways and Interactions
Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Health Sciences › Medicine › Rheumatology › Rheumatoid Arthritis Research and Therapies
Keywords: interleukin-6, cytokines, inflammation, acute phase response, acute phase proteins, hematopoiesis, immunomodulation
MeSH terms: Amino Acid Sequence, Animals, Humans, Lymphocyte Activation, Lymphocytes, Molecular Sequence Data, Receptors, Immunologic, Interleukin-6, Receptors, Interleukin-6

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Interleukin-6: an overview

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