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Cited by 585

The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.

Onychomycosis: Pathogenesis, Diagnosis, and Management

Open access
Elewski, Boni E.·1998·Clinical Microbiology Reviews

Abstract

SUMMARY: Although not life-threatening, onychomycosis (a fungal infection of the nail, usually caused by a dermatophyte) constitutes an important public health problem because of its high prevalence (about 10% of the U.S. population) and associated morbidity. The disease can have certain negative consequences for patients, such as pain, and can potentially undermine work and social lives. This review discusses the etiology, classification, diagnosis, and treatment of onychomycosis. Four types of onychomycosis are recognized based on the site and pattern of fungal invasion. Dermatophyte fungi are the predominant pathogens, but yeasts (especially Candida albicans) and nondermatophyte molds may also be implicated. Accurate diagnosis requires direct microscopy and fungal culture. The differential diagnosis includes psoriasis, lichen planus, onychogryphosis, and nail trauma. Onychomycosis is more difficult to treat than most dermatophytoses because of the inherent slow growth of the nail. Older antifungal agents (ketoconazole and griseofulvin) are unsuitable for onychomycosis because of their relatively poor efficacy and potential adverse effects. Three recently developed antimycotic agents (fluconazole, itraconazole, and terbinafine) offer high cure rates and good safety profiles. In addition, the short treatment times (<3 months) and intermittent dosing schedules are likely to enhance compliance and reduce the costs of therapy.

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Metadata

Authors
Elewski, B. E.
Venue
Clinical Microbiology Reviews
Published
1998-07
Volume
11
Issue
3
Pages
415-429
ISSN
  • 0893-8512 (ISSN-L)
  • 1098-6618
OpenAlex
W2109533181
Cited by
585
References
28
FWCI
5.84
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Onychomycosis: Pathogenesis, Diagnosis, and Management. https://app.cochat.ai/papers/10.1128/cmr.11.3.415
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Elewski, B. E. (1998). Onychomycosis: Pathogenesis, Diagnosis, and Management. Clinical Microbiology Reviews. https://doi.org/10.1128/cmr.11.3.415

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.