The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Regulation and Function of T-Cell-Mediated Immunity during Toxoplasma gondii Infection
Open accessAbstract
SUMMARY: The intracellular protozoan Toxoplasma gondii is a widespread opportunistic parasite of humans and animals. Normally, T. gondii establishes itself within brain and skeletal muscle tissues, persisting for the life of the host. Initiating and sustaining strong T-cell-mediated immunity is crucial in preventing the emergence of T. gondii as a serious pathogen. The parasite induces high levels of gamma interferon (IFN-γ) during initial infection as a result of early T-cell as well as natural killer (NK) cell activation. Induction of interleukin-12 by macrophages is a major mechanism driving early IFN-γ synthesis. The latter cytokine, in addition to promoting the differentiation of Th1 effectors, is important in macrophage activation and acquisition of microbicidal functions, such as nitric oxide release. During chronic infection, parasite-specific T lymphocytes release high levels of IFN-γ, which is required to prevent cyst reactivation. T-cell-mediated cytolytic activity against infected cells, while easily demonstrable, plays a secondary role to inflammatory cytokine production. While part of the clinical manifestations of toxoplasmosis results from direct tissue destruction by the parasite, inflammatory cytokine-mediated immunopathologic changes may also contribute to disease progression.
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Cites
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Cited by
Meredith, M. M., Liu, K., Darrasse-Jeze, G., Kamphorst, A. O., Schreiber, H. A., Guermonprez, P., Idoyaga, J., Cheong, C., Yao, K.-H., Niec, R. E., et al. (2012) · Journal of Experimental Medicine · doi:10.1084/jem.20112675 · Cited by 524
CCR5 provides a signal for microbial induced production of IL-12 by CD8α+ dendritic cells
Aliberti, J., Reis e Sousa, C., Schito, M., Hieny, S., Wells, T., Huffnagle, G. B., & Sher, A. (2000) · Nature Immunology · doi:10.1038/76957 · Cited by 349
Arling, T. A., Yolken, R. H., Lapidus, M., Langenberg, P., Dickerson, F. B., Zimmerman, S. A., Balis, T., Cabassa, J. A., Scrandis, D. A., Tonelli, L. H., et al. (2009) · Journal of Nervous & Mental Disease · doi:10.1097/nmd.0b013e3181c29a23 · Cited by 213
Toxoplasma gondii Infection and Self-directed Violence in Mothers
Pedersen, M. G., Mortensen, P. B., Norgaard-Pedersen, B., & Postolache, T. T. (2012) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2012.668 · Cited by 206
GRA7 provides protective immunity in cocktail DNA vaccines against Toxoplasma gondii
JONGERT, E., DE CRAEYE, S., DEWIT, J., & HUYGEN, K. (2007) · Parasite Immunology · doi:10.1111/j.1365-3024.2007.00961.x · Cited by 74
Metadata
- Authors
- Denkers, E. Y., & Gazzinelli, R. T.
- Venue
- Clinical Microbiology Reviews
- Publisher
- American Society for Microbiology
- Published
- 1998-10
- Volume
- 11
- Issue
- 4
- Pages
- 569-588
- ISSN
- 0893-8512 (ISSN-L)
- 1098-6618
- OpenAlex
- W2133868033
- Cited by
- 701
- References
- 7
- FWCI
- 15.35
- Type
- journal article
- Language
- en
- Open access
- green
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- Denkers, E. Y., & Gazzinelli, R. T. (1998). Regulation and Function of T-Cell-Mediated Immunity during Toxoplasma gondii Infection. Clinical Microbiology Reviews. https://doi.org/10.1128/cmr.11.4.569
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
