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The DOI matches its Crossref record; 169 of the 169 references it cites were found in a registry or an index.

Worldwide Haemophilus influenzae Type b Disease at the Beginning of the 21st Century: Global Analysis of the Disease Burden 25 Years after the Use of the Polysaccharide Vaccine and a Decade after the Advent of Conjugates

Peltola, Heikki·2000·Clinical Microbiology Reviews
DOI 10.1128/cmr.13.2.302-317.2000
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Abstract

SUMMARY: Vaccination against Haemophilus influenzae type b (Hib) diseases began a quarter of a century ago with a polysaccharide vaccine; this vaccine was followed by four different conjugates 10 years later. In this review, the burden of global Hib disease is quantified following this 25-year period of vaccine availability to determine the potential impact of conjugate vaccines. This task was accomplished by analysis of data available in 10 languages in 75 geographical regions of over 50 countries. All severe Hib diseases, not only meningitis, were characterized, and special attention was paid to the most vulnerable age group, i.e., children aged 0 to 4 years. Prior to vaccination, the weighted worldwide incidence of meningitis in patients younger than 5 years was 57/100,000, and for all Hib diseases except nonbacteremic pneumonia, it was 71/100,000, indicating 357,000 and 445,000 cases per year, respectively. At least 108,500 of these children died. For all age groups combined, there were 486,000 cases of Hib disease, excluding pneumonia, with 114,200 deaths and probably an equal number of sequelae per annum. If the figures for nonbacteremic pneumonia are included, a conservative estimate is that over 2.2 million cases of infection and 520,000 deaths from Hib disease occurred worldwide, but the true numbers might have been greater. Despite these large numbers and availability of safe and efficacious vaccines, only 38,000 cases annually are prevented—a meager 8% or less than a 2% reduction in cases, depending on whether nonbacteremic pneumonia is included in the calculations. Although vaccination has had great success in some affluent countries, the current level of activity has had a very small impact globally. The use of conjugates, preferably with a reduced number of doses and in combination with other vaccines or perhaps in fractional doses, should be extended to less privileged countries, where most Hib disease occurs.

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Citations

Cites

Research works printed but not linked: 28

  1. Benoist A. C. de Laurent E. Goulet V. Infections invasives à Haemophilus influenzae,Listeria monocytogenes, méningocoque, pneumocoque, streptocoques groupe A et groupe B en France en 1997—évolution 1991–1997. Bull. Épidémiol. Hebdom. 15 1999 57 59
  2. Boehme C. Soto L. Rodrı́guez G. Serra J. Illesca V. Reydet P. Tres años de meningitis bacteriana en servicio de pediatrı́a del Hospital Regional de Temuco. Rev. Med. Chile 121 1993 6633 6638
  3. Boletim Epidemiologico de Curitiba Comportamento epidemiológico da meningite por Haemophilus influenzae B antes e após a introduçâo da vacina anti-Haemophilus influenzae B no calendário de imunizaçôes de rotina no municı́pio de Curitiba. Bol. Epidemiol. Curitiba 9 1997 2 3
  4. Bos E. Vu M. T. Massiah E. Bulatao R. A. Estimates and projections with related demographic statistics. World population projections 1994–1995 ed. 1994 The World Bank The Johns Hopkins University Press Baltimore Md
  5. Cadoz M. Denis F. Diop Mar I. Etude épidemiologique des cas de méningites purulentes hospitalises à Dakar pendant la decennie 1970–1979. Bull. W. H. O. 59 1981 575 584
  6. Canada Diseases Weekly Report Statement on Haemophilus b polysaccharide vaccine. Can. Dis. Weekly Rep. 12 1986 33 35
  7. Caro-Cassali M. Vargas-Campos A. Mohs-Villalta Arguedas-Mohs A. Enfermedad sistémica por Haemophilus influenzae tipo b en el Hospital Nacional de Niños, un año después de la introducción de la vacuna conjugada. Bol. Med. Hosp. Infant. Mex. 52 1995 426 430
  8. Demina A. A. Epidemiology of invasive infections caused by H. influenzae type b. Int. Med. J. 2 1998 315 322 (In Russian.)
  9. Desgrandchamps D. Schmid R. Zimmermann H. P. Imahorn P. Kabus K. Schubiger G. Auswirkung der konjugiertern PRP-Impfstoffe auf die Inzidenz invasiver Erkrankungen durch Haemophilus influenzae Typ b im Kindesalter. Schweiz. Med. Wochenschr. 124 1994 575 582
  10. Feklisova L. Shebekova V. Demina A. Spirikhina L. V. Bylinkina S. Samsonova I. Gracheva A. Pneumonia in children caused by H. influenzae type b and pneumococcus. Vrach. Del. 5 1998 34 35 (In Russian.)
  11. Ferreira O. S. Carvalho da C M. R. Estudo comparativo entre os resultados das culturas do material colhido pela “swab” faringeo e pela puncao pulmonar, em 58 crianças portados de pneumonia aguda. J. Pediatr. 48 1980 211
  12. Fogarty J. Moving towards elimination of Hib disease in Ireland. Forum 12 1996 S3 S4
  13. Gordon L. K. Characterization of a hapten-carrier conjugate vaccine: H. influenzae diphtheria conjugate vaccine Modern approaches to vaccines. Chanock R. M. Lerner R. A. 1984 393 396 Cold Spring Harbor Laboratory Press Cold Spring Harbor N.Y
  14. Isenberg H. Haemophilus-Erkrankungen: der neue Impfstoff “Hib-Vaccinol.” Soz. Paediatr. Prax. Klin. 12 1990 628 634
  15. Jónsdóttir K. E. Hansen H. Gudbjörnsdottir H. Gudmundsdottir M. Ólafsson Ó. Jónasson M. Schaart W. Barreto L. Epidemiology of invasive Haemophilus influenzae b (Hib) disease in Iceland from 1974 and impact of vaccination programme launched in 1989. Arct. Med. Res. 53 (Suppl. 2) 1994 619 621
  16. Kreidl P. von Sölder B. Fischer H. Mohsenipur I. Schmutzhard E. Allerberger F. Dierich M. P. Haemophilus influenzae-Meningitis in Tirol und Vorarlberg vor und nach Einführung der Impfung gegen Haemophilus influenzae Typ b. Mitt. Oesterr. Sanitaetsverwalt. 98 1997 287 289
  17. Lennon D. Walker W. Voss L. Gillies M. Martin D. Ashton T. Gillespie J. Baker M. The case for Haemophilus influenzae type b vaccination in New Zealand. Commun. Dis. N. Z. 2 1992 89 96
  18. Murray C. J. L. Lopez A. D. Global burden of disease and injury series: global health statistics. A compendium of incidence prevalence and mortality estimates for over 200 conditions. 1996 Harvard University Press Cambridge Mass
  19. Narchi H. Kulaylat N. Regional Haemophilus influenzae type b immunization program: a success or a false sense of security. Saudi Med. J. 18 1997 155 157
  20. Rauter L. Mutz I. Haemophilus influenzae-Meningitis der Jahre 1983 bis 1992—Epidemiologie und Folgen der Erkrankung. Wien. Klin. Wochenschr. 106/7 1994 187 192
  21. Rodrigues de Souza R. Meningite por Haemophilus influenzae b. Aspectos clı́nicos, epidemiológicos e laboratoriais no municı́pio do Rio de Janeiro. Clin. Pediatr. 17 1993 56 65
  22. Rozov T. Sakane P. T. Novaes J. R. C. Contribuiçao ao estudo de etilogia das pneumopatias de infancia, por meio da aspiraçao pulmonar transcutanea. Pediatr. Prat. 45 1974 221 232
  23. Schuster A. C. Pino M. C. Neira M. S. Vildosola C. S. Faini L. M. La punción biopsial pulmonar como metodo diagnostico de las neumopatı́as de la infancia. Pediatrı́a 9 1966 9 12
  24. Setarunnahar A. Chowdhury A. Hoq F. Aetiological agents of meningitis in Bangladeshi children. Indian J. Med. Microbiol. 6 1985 81 85
  25. Shinefield H. Black S. Conjugate Hib vaccines and their combinations: present success and future possibilities. JAMA SEA 9 1993 S20 S23
  26. Uduman S. A. Devadas K. Mathew T. Darwish M. K. Khidir A. Childhood bacterial meningitis: the experience of Al Ain Hospital in Eastern region of UAE. Emirates Med. J. 12 1994 227 233
  27. Vutuc C. Kunze M. Haemophilus influenzae—meningitis in Österreich: Inzidenz 1990–1992. Wien. Klin. Wochenschr. 107 1995 256 257
  28. Zielen S. Ahrens P. Hofmann D. Efficacy of Hib vaccine. Lancet 344 1994 828 · DOI

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Metadata

Authors
Peltola, H.
Affiliations
<!--label omitted: 1-->Helsinki University Central Hospital, Hospital for Children and Adolescents, Helsinki, Finland
Venue
Clinical Microbiology Reviews
Publisher
American Society for Microbiology
Published
2000-04
Volume
13
Issue
2
Pages
302-317
ISSN
  • 0893-8512
  • 1098-6618
DOI
10.1128/cmr.13.2.302-317.2000
Cited by
1,364
References
169
Language
en
Licence
journals.asm.org/non-commercial-tdm-license (tdm)

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