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Cited by 438

The DOI matches its Crossref record; 132 of the 132 references it cites were found in a registry or an index.

Respiratory Syncytial Virus Infection in Adults

Falsey, Ann R., Walsh, Edward E.·2000·Clinical Microbiology Reviews
DOI 10.1128/cmr.13.3.371
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Abstract

SUMMARY: Respiratory syncytial virus (RSV) is now recognized as a significant problem in certain adult populations. These include the elderly, persons with cardiopulmonary diseases, and immunocompromised hosts. Epidemiological evidence indicates that the impact of RSV in older adults may be similar to that of nonpandemic influenza. In addition, RSV has been found to cause 2 to 5% of adult community-acquired pneumonias. Attack rates in nursing homes are approximately 5 to 10% per year, with significant rates of pneumonia (10 to 20%) and death (2 to 5%). Clinical features may be difficult to distinguish from those of influenza but include nasal congestion, cough, wheezing, and low-grade fever. Bone marrow transplant patients prior to marrow engraftment are at highest risk for pneumonia and death. Diagnosis of RSV infection in adults is difficult because viral culture and antigen detection are insensitive, presumably due to low viral titers in nasal secretions, but early bronchoscopy is valuable in immunosuppressed patients. Treatment of RSV in the elderly is largely supportive, whereas early therapy with ribavirin and intravenous gamma globulin is associated with improved survival in immunocompromised persons. An effective RSV vaccine has not yet been developed, and thus prevention of RSV infection is limited to standard infection control practices such as hand washing and the use of gowns and gloves.

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Metadata

Authors
Falsey, A. R., & Walsh, E. E.
Venue
Clinical Microbiology Reviews
Publisher
American Society for Microbiology
Published
2000-07
Volume
13
Issue
3
Pages
371-384
ISSN
  • 0893-8512 (ISSN-L)
  • 1098-6618
DOI
10.1128/cmr.13.3.371
OpenAlex
W4211207275
Cited by
438
References
132
FWCI
7.99
Type
journal article
Language
en
Open access
closed
Licence
journals.asm.org/non-commercial-tdm-license (tdm)

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Falsey, A. R., & Walsh, E. E. (2000). Respiratory Syncytial Virus Infection in Adults. Clinical Microbiology Reviews. https://doi.org/10.1128/cmr.13.3.371

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