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Cited by 565

The DOI matches its Crossref record; 146 of the 146 references it cites were found in a registry or an index.

Treatment of Giardiasis

Open access
Gardner, Timothy B., Hill, David R.·2001·Clinical Microbiology Reviews
DOI 10.1128/cmr.14.1.114-128.2001
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Abstract

SUMMARY: Giardia lamblia is both the most common intestinal parasite in the United States and a frequent cause of diarrheal illness throughout the world. In spite of its recognition as an important human pathogen, there have been relatively few agents used in therapy. This paper discusses each class of drugs used in treatment, along with their mechanism of action, in vitro and clinical efficacy, and side effects and contraindications. Recommendations are made for the preferred treatment in different clinical situations. The greatest clinical experience is with the nitroimidazole drugs, i.e., metronidazole, tinidazole, and ornidazole, which are highly effective. A 5- to 7-day course of metronidazole can be expected to cure over 90% of individuals, and a single dose of tinidazole or ornidazole will cure a similar number. Quinacrine, which is no longer produced in the United States, has excellent efficacy but may be poorly tolerated, especially in children. Furazolidone is an effective alternative but must be administered four times a day for 7 to 10 days. Paromomycin may be used during early pregnancy, because it is not systematically absorbed, but it is not always effective. Patients who have resistant infection can usually be cured by a prolonged course of treatment with a combination of a nitroimidazole with quinacrine.

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Crossref · 10.1128/cmr.14.1.114-128.2001

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Metadata

Authors
Gardner, T. B., & Hill, D. R.
Venue
Clinical Microbiology Reviews
Publisher
American Society for Microbiology
Published
2001-01
Volume
14
Issue
1
Pages
114-128
ISSN
  • 0893-8512 (ISSN-L)
  • 1098-6618
DOI
10.1128/cmr.14.1.114-128.2001
OpenAlex
W2152173141
Cited by
565
References
146
FWCI
9.53
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Treatment of Giardiasis. https://app.cochat.ai/papers/10.1128/cmr.14.1.114-128.2001
The paper
Gardner, T. B., & Hill, D. R. (2001). Treatment of Giardiasis. Clinical Microbiology Reviews. https://doi.org/10.1128/cmr.14.1.114-128.2001

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.