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Endocarditis Due to Rare and Fastidious Bacteria

Open access
Brouqui, P., Raoult, D.·2001·Clinical Microbiology Reviews

Abstract

SUMMARY: The etiologic diagnosis of infective endocarditis is easily made in the presence of continuous bacteremia with gram-positive cocci. However, the blood culture may contain a bacterium rarely associated with endocarditis, such as Lactobacillus spp., Klebsiella spp., or nontoxigenic Corynebacterium, Salmonella, Gemella, Campylobacter, Aeromonas, Yersinia, Nocardia, Pasteurella, Listeria, or Erysipelothrix spp., that requires further investigation to establish the relationship with endocarditis, or the blood culture may be uninformative despite a supportive clinical evaluation. In the latter case, the etiologic agents are either fastidious extracellular or intracellular bacteria. Fastidious extracellular bacteria such as Abiotrophia, HACEK group bacteria, Clostridium, Brucella, Legionella, Mycobacterium, and Bartonella spp. need supplemented media, prolonged incubation time, and special culture conditions. Intracellular bacteria such as Coxiella burnetii cannot be isolated routinely. The two most prevalent etiologic agents of culture-negative endocarditis are C. burnetti and Bartonella spp. Their diagnosis is usually carried out serologically. A systemic pathologic examination of excised heart valves including periodic acid-Schiff (PAS) staining and molecular methods has allowed the identification of Whipple's bacillus endocarditis. Pathologic examination of the valve using special staining, such as Warthin-Starry, Gimenez, and PAS, and broad-spectrum PCR should be performed systematically when no etiologic diagnosis is evident through routine laboratory evaluation.

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Crossref · 10.1128/cmr.14.1.177-207.2001

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Metadata

Authors
Brouqui, P., & Raoult, D.
Venue
Clinical Microbiology Reviews
Published
2001-01
Volume
14
Issue
1
Pages
177-207
ISSN
  • 0893-8512 (ISSN-L)
  • 1098-6618
OpenAlex
W2146304151
Cited by
754
References
9
FWCI
19.49
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Endocarditis Due to Rare and Fastidious Bacteria. https://app.cochat.ai/papers/10.1128/cmr.14.1.177-207.2001
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Brouqui, P., & Raoult, D. (2001). Endocarditis Due to Rare and Fastidious Bacteria. Clinical Microbiology Reviews. https://doi.org/10.1128/cmr.14.1.177-207.2001

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.