Antiviral Actions of Interferons

Cites (474)

Items 201–400 of 474

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2. Identification of Distinct Signaling Pathways Leading to the Phosphorylation of Interferon Regulatory Factor 3
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4. IMPACT OF VIRUS INFECTION ON HOST CELL PROTEIN SYNTHESIS
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5. Interferon Resistance of Hepatitis C Virus Genotype 1b: Relationship to Nonstructural 5A Gene Quasispecies Mutations
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7. The Herpes Simplex Virus US11 Protein Effectively Compensates for the γ134.5 Gene if Present before Activation of Protein Kinase R by Precluding Its Phosphorylation and That of the α Subunit of Eukaryotic Translation Initiation Factor 2
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8. Editing of Glutamate Receptor B Subunit Ion Channel RNAs by Four Alternatively Spliced DRADA2 Double-Stranded RNA Adenosine Deaminases
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15. Characterization of β-R1, a Gene That Is Selectively Induced by Interferon β (IFN-β) Compared with IFN-α
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16. Neuronal nitric oxide synthase, a modular enzyme formed by convergent evolution: structure studies of a cysteine thiolate‐liganded heme protein that hydroxylates L‐arginine to produce NO as a cellular signal
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18. Mutant Influenza Viruses with a Defective NS1 Protein Cannot Block the Activation of PKR in Infected Cells
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19. Regulation of the interferon-induced PKR: can viruses cope?
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20. Impaired Antiviral Response and Alpha/Beta Interferon Induction in Mice Lacking Beta Interferon
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21. The Evolution of the Type I Interferons1
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22. Activation of Different Stat5 Isoforms Contributes to Cell-Type-Restricted Signaling in Response to Interferons
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23. Human MxA Protein Protects Mice Lacking a Functional Alpha/Beta Interferon System against La Crosse Virus and Other Lethal Viral Infections
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24. Mechanism of interferon action: Identification of a RNA binding domain within the N-terminal region of the human RNA-dependent P1/eIF-2α protein kinase
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25. Protection against apoptosis by the vaccinia virus SPI-2 (B13R) gene product
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26. Type I interferons are essential mediators of apoptotic death in virally infected cells
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28. Acute phase response factor and additional members of the interferon-stimulated gene factor 3 family integrate diverse signals from cytokines, interferons, and growth factors.
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29. Anticellular and antiviral effects of pppA(2′p5′A)n
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30. Inhibition of influenza viral mRNA synthesis in cells expressing the interferon-induced Mx gene product
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31. Regulation of Interferon-γ Gene Expression
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32. Interactions between Double-Stranded RNA Regulators and the Protein Kinase DAI
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33. Mechanism of Interferon Action
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34. Intrinsic molecular activities of the interferon-induced 2-5A-dependent RNase.
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35. Structural Requirements for RNA Editing in Glutamate Receptor Pre-mRNAs by Recombinant Double-stranded RNA Adenosine Deaminase
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36. Mechanism of Interferon Action: Double-Stranded RNA-Specific Adenosine Deaminase from Human Cells Is Inducible by Alpha and Gamma Interferons
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37. Identification of distinct regions of 5' flanking DNA that mediate constitutive, IFN-gamma, STAT1, and TGF-beta-regulated expression of the class II transactivator gene.
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38. Sendai Virus and Simian Virus 5 Block Activation of Interferon-Responsive Genes: Importance for Virus Pathogenesis
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39. Mutagenic Analysis of Double-stranded RNA Adenosine Deaminase, a Candidate Enzyme for RNA Editing of Glutamate-gated Ion Channel Transcripts
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40. Vaccinia Virus E3L Protein Is an Inhibitor of the Interferon (IFN)-Induced 2-5A Synthetase Enzyme
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41. Mx proteins: GTPases with antiviral activity
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42. Isolation and Characterization of a New Mutant Human Cell Line Unresponsive to Alpha and Beta Interferons
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43. Cytokines and JAK–STAT Signaling
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44. The Interferon-Inducible p202 Protein as a Modulator of Transcription: Inhibition of NF-κB, c-Fos, and c-Jun Activities
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45. HIV-1 Tat Directly Interacts with the Interferon-Induced, Double-Stranded RNA-Dependent Kinase, PKR
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46. The Tat Protein of Human Immunodeficiency Virus Type 1 Is a Substrate and Inhibitor of the Interferon-induced, Virally Activated Protein Kinase, PKR
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47. Cytokine-Mediated Control of Viral Infections
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48. Inhibition of Hepatitis B Virus Replication during Adenovirus and Cytomegalovirus Infections in Transgenic Mice
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49. Effects of Interferon-γ and Lipopolysaccharide on Macrophage Iron Metabolism Are Mediated by Nitric Oxide-induced Degradation of Iron Regulatory Protein 2
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50. HIV-1 TAR RNA Has an Intrinsic Ability to Activate Interferon-Inducible Enzymes
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51. Transcriptional Induction by Double-stranded RNA Is Mediated by Interferon-stimulated Response Elements without Activation of Interferon-stimulated Gene Factor 3
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52. Human MxA protein inhibits tick-borne Thogoto virus but not Dhori virus
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53. Activation of the IFN-Inducible Enzyme RNase L Causes Apoptosis of Animal Cells
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54. Modulation of Major Histocompatibility Class II Protein Expression by Varicella-Zoster Virus
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55. Interferon-Responsive Regulatory Elements in the Promoter of the Human 2′,5′-Oligo(A) Synthetase Gene
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56. Chicken double-stranded RNA adenosine deaminase has apparent specificity for Z-DNA.
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57. Characterization of the Effects of Hepatitis C Virus Nonstructural 5A Protein Expression in Human Cell Lines and on Interferon–Sensitive Virus Replication
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58. Identification of Distinct Regions of 5′ Flanking DNA That Mediate Constitutive, IFN-γ, STAT1, and TGF-β-Regulated Expression of the Class II Transactivator Gene
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59. Mutants of the RNA-Dependent Protein Kinase (PKR) Lacking Double-Stranded RNA Binding Domain I Can Act as Transdominant Inhibitors and Induce Malignant Transformation
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60. Constitutive Expression of a 2′,5′-Oligoadenylate Synthetase cDNA Results in Increased Antiviral Activity and Growth Suppression
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61. Targeted disruption of the interferon-γ receptor 2 gene results in severe immune defects in mice
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62. A longitudinal study of T1 hypointense lesions in relapsing MS
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64. Induction of 2′5′-oligoadenylate synthetase activity and a new protein by chick interferon
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65. The Cellular Inhibitor of the PKR Protein Kinase, P58IPK, Is an Influenza Virus-activated Co-chaperone That Modulates Heat Shock Protein 70 Activity
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66. Functionally Distinct Double-stranded RNA-binding Domains Associated with Alternative Splice Site Variants of the Interferon-inducible Double-stranded RNA-specific Adenosine Deaminase
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67. Mechanism of interferon action: evidence for intermolecular autophosphorylation and autoactivation of the interferon-induced, RNA-dependent protein kinase PKR
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68. Role for Gamma Interferon in Control of Herpes Simplex Virus Type 1 Reactivation
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69. DRBP76, a Double-stranded RNA-binding Nuclear Protein, Is Phosphorylated by the Interferon-induced Protein Kinase, PKR
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70. Activation of the ppp(A2'p)nA system in interferon-treated, Herpes simplex virus-infected cells and evidence for novel inhibitors of the ppp(A2'p)nA-dependent RNase
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71. Expression of Hepatitis C Virus Proteins Interferes with the Antiviral Action of Interferon Independently of PKR-Mediated Control of Protein Synthesis
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72. Regulation of p53-dependent apoptosis, transcriptional repression, and cell transformation by phosphorylation of the 55-kilodalton E1B protein of human adenovirus type 5
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73. Interferon-induced protein Mx accumulates in nuclei of mouse cells expressing resistance to influenza viruses
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74. cDNA Structures and Regulation of Two Interferon-Induced Human Mx Proteins
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75. Negative regulation of cytokine signaling: STAT-induced STAT inhibitor
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76. Identification of the double-stranded RNA-binding domain of the human interferon-inducible protein kinase.
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77. The Vaccinia Virus E3L Gene Product Interacts with both the Regulatory and the Substrate Binding Regions of PKR: Implications for PKR Autoregulation
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78. Interferon regulatory factor subcellular localization is determined by a bipartite nuclear localization signal in the DNA-binding domain and interaction with cytoplasmic retention factors.
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79. Vesicular stomatitis virus defective interfering particles can contain extensive genomic sequence rearrangements and base substitutions
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80. RNase-L-dependent Destabilization of Interferon-induced mRNAs
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81. The 58-kilodalton inhibitor of the interferon-induced double-stranded RNA-activated protein kinase is a tetratricopeptide repeat protein with oncogenic properties.
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82. Dominant-negative mutants of human MxA protein: domains in the carboxy-terminal moiety are important for oligomerization and antiviral activity
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83. The double‐stranded RNA‐dependent protein kinase is also activated by heparin
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84. Structural Requirements for Double-Stranded RNA Binding, Dimerization, and Activation of the Human eIF-2α Kinase DAI in Saccharomyces cerevisiae
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85. Identification of 69‐kd and 100‐kd forms of 2‐5A synthetase in interferon‐treated human cells by specific monoclonal antibodies.
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91. Interferon-regulated Mx genes are not responsive to interleukin-1, tumor necrosis factor, and other cytokines
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92. Mechanism of interferon action. Increased phosphorylation of protein synthesis initiation factor eIF-2 alpha in interferon-treated, reovirus-infected mouse L929 fibroblasts in vitro and in vivo.
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93. Interferon-induced 56,000 Mr protein and its mRNA in human cells: molecular cloning and partial sequence of the cDNA
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94. Activation induces rapid and profound alterations in the trafficking of T cells
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95. 2'5'Oligo(A) polymerase activity and inhibition of viral RNA synthesis in interferon-treated HeLa cells
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96. Gamma Interferon (IFN-γ) Receptor Null-Mutant Mice Are More Susceptible to Herpes Simplex Virus Type 1 Infection than IFN-γ Ligand Null-Mutant Mice
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97. IRF-1 induced cell growth inhibition and interferon induction requires the activity of the protein kinase PKR.
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98. RNA Editing
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99. The Emerging Role of the Interferon-Induced PKR Protein Kinase as an Apoptotic Effector: A New Face of Death?
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100. Sendai Virus Blocks Alpha Interferon Signaling to Signal Transducers and Activators of Transcription
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101. Functional Characterization of the RNA-binding Domain and Motif of the Double-stranded RNA-dependent Protein Kinase DAI (PKR)
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102. Viral interference with apoptosis
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103. Double-Stranded RNA-Dependent Protein Kinase (PKR) Is Regulated by Reovirus Structural Proteins
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104. GTP-bound Human MxA Protein Interacts with the Nucleocapsids of Thogoto Virus (Orthomyxoviridae)
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105. Human Immunodeficiency Virus Type 1 Tat Protein Activates Transcription Factor NF-κB through the Cellular Interferon-Inducible, Double-Stranded RNA-Dependent Protein Kinase, PKR
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106. Interferon-γ Protects against Herpes Simplex Virus Type 1-Mediated Neuronal Death
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107. Two Functionally Distinct RNA-Binding Motifs in the Regulatory Domain of the Protein Kinase DAI
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108. The gene specifying RNase E (rne) and a gene affecting mRNA stability (ams) are the same gene
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109. Nuclear Factor-90 of Activated T-Cells: A Double-Stranded RNA-Binding Protein and Substrate for the Double-Stranded RNA-Dependent Protein Kinase, PKR
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110. The 69-kDa 2-5A synthetase is composed of two homologous and adjacent functional domains.
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111. The Ifi 200 genes: An emerging family of IFN-inducible genes
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112. Characterization of the 5′-flanking region of the human RNA-specific adenosine deaminase ADAR1 gene and identification of an interferon-inducible ADAR1 promoter
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113. The SH2 Domain-containing Tyrosine Phosphatase PTP1D Is Required for Interferon α/β-induced Gene Expression
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114. Mechanisms of Viral Interference with MHC Class I Antigen Processing and Presentation
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115. Reconstitution of Virus-mediated Expression of Interferon α Genes in Human Fibroblast Cells by Ectopic Interferon Regulatory Factor-7
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117. Generation of a Mutant Form of Protein Synthesis Initiation Factor eIF-2 Lacking the Site of Phosphorylation by eIF-2 Kinases
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119. Binding of the Protein Kinase PKR to RNAs with Secondary Structure Defects: Role of the Tandem A−G Mismatch and Noncontiguous Helixes
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128. Serotonin-2C Receptor Pre-mRNA Editing in Rat Brain andin Vitro by Splice Site Variants of the Interferon-inducible Double-stranded RNA-specific Adenosine Deaminase ADAR1
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129. How Viruses Escape from Cytotoxic T Lymphocytes: Molecular Parameters and Players
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130. Identification of a Second Interferon-Regulated Murine Mx Gene
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131. Degradation of the interferon-induced 68,000-M(r) protein kinase by poliovirus requires RNA
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